(37 nodes) Regulation of osteoclast differentiation network (Sarcophilus harrisii)

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Your Input:
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
	MTOR	Serine/threonine-protein kinase mTOR. (1680 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
	IL17A	Interleukin 17A. (154 aa)
	TMEM178A	Transmembrane protein 178A. (167 aa)
	TMEM64	Transmembrane protein 64. (334 aa)
	GPR137B	G protein-coupled receptor 137B. (401 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	FSTL3	Follistatin like 3. (251 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (832 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (630 aa)
	RASSF2	Ras association domain family member 2. (327 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1192 aa)
	CSF1	Uncharacterized protein. (560 aa)
	TFE3	Transcription factor binding to IGHM enhancer 3. (533 aa)
	PRXL2A	Uncharacterized protein. (275 aa)
	FBXW7	F-box and WD repeat domain containing 7. (708 aa)
	IL23A	Interleukin 23 subunit alpha. (195 aa)
	TNFSF11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (140 aa)
	G3VAQ8_SARHA	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	NF1	Neurofibromin 1. (2775 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	PIAS3	Protein inhibitor of activated STAT 3. (629 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	KLF10	Kruppel like factor 10. (493 aa)
	IL20	Interleukin 20. (178 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
	LRRC17	Leucine rich repeat containing 17. (441 aa)
	MITF	Melanocyte inducing transcription factor. (526 aa)
	TCTA	T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (109 aa)
	PPARGC1B	PPARG coactivator 1 beta. (1011 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	FBXW9	F-box and WD repeat domain containing 9. (352 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB1	CTNNB1	ENSSHAP00000016341	ENSSHAP00000009775	cAMP responsive element binding protein 1.	Catenin beta 1.	0.647
CREB1	FOS	ENSSHAP00000016341	ENSSHAP00000020966	cAMP responsive element binding protein 1.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.741
CREB1	PIK3R1	ENSSHAP00000016341	ENSSHAP00000009338	cAMP responsive element binding protein 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.544
CSF1	IFNG	ENSSHAP00000004728	ENSSHAP00000017704	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.483
CSF1	TNFSF11	ENSSHAP00000004728	ENSSHAP00000001456	Uncharacterized protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.557
CTNNB1	CREB1	ENSSHAP00000009775	ENSSHAP00000016341	Catenin beta 1.	cAMP responsive element binding protein 1.	0.647
CTNNB1	FBXW7	ENSSHAP00000009775	ENSSHAP00000002403	Catenin beta 1.	F-box and WD repeat domain containing 7.	0.565
CTNNB1	MITF	ENSSHAP00000009775	ENSSHAP00000020661	Catenin beta 1.	Melanocyte inducing transcription factor.	0.435
CTNNB1	PIK3R1	ENSSHAP00000009775	ENSSHAP00000009338	Catenin beta 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.450
FBXW7	CTNNB1	ENSSHAP00000002403	ENSSHAP00000009775	F-box and WD repeat domain containing 7.	Catenin beta 1.	0.565
FBXW7	MTOR	ENSSHAP00000002403	ENSSHAP00000015337	F-box and WD repeat domain containing 7.	Serine/threonine-protein kinase mTOR.	0.642
FBXW9	MTOR	ENSSHAP00000018718	ENSSHAP00000015337	F-box and WD repeat domain containing 9.	Serine/threonine-protein kinase mTOR.	0.461
FOS	CREB1	ENSSHAP00000020966	ENSSHAP00000016341	Fos proto-oncogene, AP-1 transcription factor subunit.	cAMP responsive element binding protein 1.	0.741
FOS	IFNG	ENSSHAP00000020966	ENSSHAP00000017704	Fos proto-oncogene, AP-1 transcription factor subunit.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.411
FOS	MITF	ENSSHAP00000020966	ENSSHAP00000020661	Fos proto-oncogene, AP-1 transcription factor subunit.	Melanocyte inducing transcription factor.	0.573
FOS	TNFSF11	ENSSHAP00000020966	ENSSHAP00000001456	Fos proto-oncogene, AP-1 transcription factor subunit.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.520
IFNG	CSF1	ENSSHAP00000017704	ENSSHAP00000004728	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.483
IFNG	FOS	ENSSHAP00000017704	ENSSHAP00000020966	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.411
IFNG	IL12B	ENSSHAP00000017704	ENSSHAP00000022243	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.419
IFNG	IL17A	ENSSHAP00000017704	ENSSHAP00000014166	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin 17A.	0.678