STRINGSTRING
G3VA64_SARHA G3VA64_SARHA PIK3CB PIK3CB GPC3 GPC3 TNFSF11 TNFSF11 G3VF58_SARHA G3VF58_SARHA IRF6 IRF6 G3VG24_SARHA G3VG24_SARHA SAV1 SAV1 SCARB1 SCARB1 IFT74 IFT74 SERPINB1 SERPINB1 CCND1 CCND1 LIPA LIPA DACH1 DACH1 OVOL1 OVOL1 IFT52 IFT52 NOTCH1 NOTCH1 BAK1 BAK1 BAD BAD TRIM24 TRIM24 ZEB1 ZEB1 MTSS2 MTSS2 BMPR1A BMPR1A AREG AREG TGFB1 TGFB1 STAT6 STAT6 A4GNT A4GNT NCSTN NCSTN NRARP NRARP STK11 STK11 SERPINF1 SERPINF1 TP63 TP63 ITGB1BP1 ITGB1BP1 MTSS1 MTSS1 G3W189_SARHA G3W189_SARHA B4GALT1 B4GALT1 FGL1 FGL1 KDR KDR SMO SMO NKX2-5 NKX2-5 CDH13 CDH13 FST FST AGAP2 AGAP2 FGF1 FGF1 EAF2 EAF2 SDR16C5 SDR16C5 FERMT1 FERMT1 MTA3 MTA3 BMPR2 BMPR2 PROK2 PROK2 EHF EHF EYA1 EYA1 TGFA TGFA MEF2C MEF2C FGF2 FGF2 BTRC BTRC HSF4 HSF4 XBP1 XBP1 PPARD PPARD PROK1 PROK1 IL6 IL6 EPHA2 EPHA2 STK4 STK4 IGFBP4 IGFBP4 BMPER BMPER COL8A1 COL8A1 HLX HLX IGFBP5 IGFBP5 RPS6KA1 RPS6KA1 NOX5 NOX5 PSEN1 PSEN1 FSHR FSHR IFT57 IFT57 LGR4 LGR4 WDR77 WDR77 ST8SIA1 ST8SIA1 C6orf89 C6orf89 IFT172 IFT172 RB1 RB1 ERN1 ERN1 PTCH1 PTCH1 EFNB2 EFNB2 DRD2 DRD2 BCL2L2 BCL2L2 PURA PURA WNT16 WNT16 CAV2 CAV2 IQGAP3 IQGAP3 G3WR53_SARHA G3WR53_SARHA PHOX2B PHOX2B ESR1 ESR1 CAV1 CAV1 NKX3-1 NKX3-1 HGF HGF RETNLB RETNLB MED1 MED1 LOXL2 LOXL2 PHB2 PHB2 PROX1 PROX1 AR AR TGFBR1 TGFBR1 LOXL3 LOXL3 EREG EREG WNT2B WNT2B FGF7 FGF7 WNT2 WNT2 CCN3 CCN3 IFT80 IFT80 G3WYR0_SARHA G3WYR0_SARHA FLCN FLCN PDX1 PDX1 VSTM4 VSTM4 NF1 NF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3VA64_SARHARRM domain-containing protein. (423 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (449 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (140 aa)
G3VF58_SARHAFHA domain-containing protein. (2337 aa)
IRF6Interferon regulatory factor 6. (318 aa)
G3VG24_SARHAUncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
SAV1Salvador family WW domain containing protein 1. (383 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (545 aa)
IFT74Intraflagellar transport 74. (455 aa)
SERPINB1Serpin family B member 1; Belongs to the serpin family. (379 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (408 aa)
DACH1Dachshund family transcription factor 1. (464 aa)
OVOL1Ovo like transcriptional repressor 1. (239 aa)
IFT52Intraflagellar transport 52. (446 aa)
NOTCH1Notch receptor 1. (2672 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
BADUncharacterized protein. (173 aa)
TRIM24Tripartite motif containing 24. (948 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1101 aa)
MTSS2MTSS I-BAR domain containing 2. (726 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
AREGEGF-like domain-containing protein. (243 aa)
TGFB1TGF_BETA_2 domain-containing protein. (162 aa)
STAT6Signal transducer and activator of transcription. (853 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
NCSTNNicastrin. (680 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
STK11Serine/threonine kinase 11. (252 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (419 aa)
TP63Tumor protein p63. (458 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (203 aa)
MTSS1IMD domain-containing protein. (224 aa)
G3W189_SARHAUncharacterized protein; Belongs to the protein kinase superfamily. (304 aa)
B4GALT1Uncharacterized protein. (281 aa)
FGL1Fibrinogen like 1. (311 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (759 aa)
NKX2-5Homeobox domain-containing protein. (320 aa)
CDH13Cadherin 13. (608 aa)
FSTFollistatin. (343 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1167 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
EAF2ELL associated factor 2. (231 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
FERMT1Fermitin family member 1. (677 aa)
MTA3Metastasis associated 1 family member 3. (538 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
PROK2Prokineticin 2. (147 aa)
EHFETS homologous factor. (339 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
TGFATransforming growth factor alpha. (159 aa)
MEF2CMyocyte enhancer factor 2C. (467 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (634 aa)
HSF4Heat shock transcription factor 4. (501 aa)
XBP1BZIP domain-containing protein. (308 aa)
PPARDPeroxisome proliferator activated receptor delta. (442 aa)
PROK1Prokineticin 1. (105 aa)
IL6Uncharacterized protein. (212 aa)
EPHA2EPH receptor A2. (995 aa)
STK4Serine/threonine kinase 4. (487 aa)
IGFBP4Insulin like growth factor binding protein 4. (260 aa)
BMPERBMP binding endothelial regulator. (586 aa)
COL8A1Collagen type VIII alpha 1 chain. (741 aa)
HLXH2.0 like homeobox. (499 aa)
IGFBP5Insulin like growth factor binding protein 5. (160 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (660 aa)
NOX5NADPH oxidase 5. (742 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
IFT57Intraflagellar transport 57. (468 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (889 aa)
WDR77WD repeat domain 77. (303 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (361 aa)
C6orf89Chromosome 6 open reading frame 89. (394 aa)
IFT172Intraflagellar transport 172. (1757 aa)
RB1RB transcriptional corepressor 1. (848 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (922 aa)
PTCH1Patched 1. (1433 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (454 aa)
BCL2L2BCL2 like 2. (209 aa)
PURAPurine rich element binding protein A. (323 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1658 aa)
G3WR53_SARHAUncharacterized protein. (112 aa)
PHOX2BPaired like homeobox 2B. (267 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (588 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (188 aa)
NKX3-1NK3 homeobox 1. (252 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (761 aa)
RETNLBUncharacterized protein. (111 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1573 aa)
LOXL2Lysyl oxidase like 2. (770 aa)
PHB2Prohibitin. (257 aa)
PROX1Prospero homeobox 1. (664 aa)
ARUncharacterized protein. (388 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (475 aa)
LOXL3Lysyl oxidase like 3. (757 aa)
EREGEpiregulin. (165 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
CCN3Cellular communication network factor 3. (361 aa)
IFT80Intraflagellar transport 80. (777 aa)
G3WYR0_SARHAUncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
PDX1Homeobox domain-containing protein. (287 aa)
VSTM4V-set and transmembrane domain containing 4. (324 aa)
NF1Neurofibromin 1. (2775 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.