STRINGSTRING
G3VJ24_SARHA G3VJ24_SARHA ERLIN1 ERLIN1 SEC14L3 SEC14L3 SEC14L5 SEC14L5 APOE APOE SEC14L2 SEC14L2 DKKL1 DKKL1 SNAI2 SNAI2 NR0B1 NR0B1 LOC100931823 LOC100931823 DHH DHH STARD4 STARD4 CLCN2 CLCN2 ASAH1 ASAH1 SF1 SF1 SCAP SCAP CGA CGA NFKB1 NFKB1 DHCR7 DHCR7 DAB2 DAB2 CYP27C1 CYP27C1 FGF1 FGF1 ABCG4 ABCG4 CYP27B1 CYP27B1 H6PD H6PD SNAI1 SNAI1 SREBF2 SREBF2 FGFR4 FGFR4 EGR1 EGR1 SIRT1 SIRT1 INSIG1 INSIG1 BMP6 BMP6 CYP7A1 CYP7A1 DKK3 DKK3 NR1D1 NR1D1 IGF1R IGF1R ARMC5 ARMC5 ABCG1 ABCG1 DDX20 DDX20 LHCGR LHCGR G3WQ31_SARHA G3WQ31_SARHA DGKQ DGKQ IFNG IFNG IGFBP7 IGFBP7 WNT4 WNT4 REST REST ERLIN2 ERLIN2 LPCAT3 LPCAT3 PROX1 PROX1 LEP LEP STAR STAR INSIG2 INSIG2 SREBF1 SREBF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3VJ24_SARHAVitellogenin domain-containing protein. (4307 aa)
ERLIN1ER lipid raft associated 1. (353 aa)
SEC14L3SEC14 like lipid binding 3. (408 aa)
SEC14L5SEC14 like lipid binding 5. (709 aa)
APOEUncharacterized protein. (256 aa)
SEC14L2Uncharacterized protein. (409 aa)
DKKL1Uncharacterized protein. (195 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
NR0B1NR LBD domain-containing protein. (208 aa)
LOC100931823Uncharacterized protein. (403 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (399 aa)
STARD4StAR related lipid transfer domain containing 4. (221 aa)
CLCN2Chloride voltage-gated channel 2. (893 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (349 aa)
SF1Splicing factor 1. (538 aa)
SCAPSREBF chaperone. (1287 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
DHCR77-dehydrocholesterol reductase. (458 aa)
DAB2PID domain-containing protein. (457 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (443 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ABCG4ATP binding cassette subfamily G member 4. (652 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (757 aa)
SNAI1Snail family transcriptional repressor 1. (259 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1125 aa)
FGFR4Fibroblast growth factor receptor. (807 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (528 aa)
SIRT1Sirtuin 1. (597 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
BMP6Bone morphogenetic protein 6. (439 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (507 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (377 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (598 aa)
IGF1RTyrosine-protein kinase receptor. (1061 aa)
ARMC5Armadillo repeat containing 5. (817 aa)
ABCG1ABC transporter domain-containing protein. (679 aa)
DDX20DEAD-box helicase 20; Belongs to the DEAD box helicase family. (696 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (698 aa)
G3WQ31_SARHARecep_L_domain domain-containing protein. (181 aa)
DGKQDiacylglycerol kinase. (859 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
IGFBP7Insulin like growth factor binding protein 7. (319 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (264 aa)
RESTUncharacterized protein. (918 aa)
ERLIN2ER lipid raft associated 2. (338 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (440 aa)
PROX1Prospero homeobox 1. (664 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (239 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1068 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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