(46 nodes) Extracellular matrix binding network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DAG1	Dystroglycan 1. (895 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (799 aa)
	PXDN	Peroxidasin. (1487 aa)
	ITGA2B	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1057 aa)
	GPC1	Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (536 aa)
	PXDNL	Peroxidasin like. (1463 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (942 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	VTN	SMB domain-containing protein. (474 aa)
	G3WBG7_SARHA	Galectin. (131 aa)
	G3WB94_SARHA	Galectin. (126 aa)
	NTN4	Netrin 4. (610 aa)
	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif 15. (950 aa)
	ECM1	Extracellular matrix protein 1. (573 aa)
	G3W9F7_SARHA	Uncharacterized protein. (358 aa)
	G3W9A7_SARHA	VWFD domain-containing protein. (307 aa)
	TINAGL1	Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family. (467 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1169 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1013 aa)
	ADGRG6	Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1175 aa)
	OLFML2B	Olfactomedin like 2B. (769 aa)
	MCAM	Uncharacterized protein. (525 aa)
	FBLN2	Fibulin 2. (1188 aa)
	NID1	Uncharacterized protein. (79 aa)
	ACHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (610 aa)
	SPARC	Secreted protein acidic and cysteine rich. (303 aa)
	RPSA	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (360 aa)
	SPOCK2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (338 aa)
	THBS1	Thrombospondin 1. (1180 aa)
	G3VTU3_SARHA	Uncharacterized protein. (384 aa)
	G3VT65_SARHA	Uncharacterized protein. (1642 aa)
	ADGRG1	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (687 aa)
	BCAM	Basal cell adhesion molecule (Lutheran blood group). (624 aa)
	G3VPX1_SARHA	Uncharacterized protein. (1537 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (405 aa)
	LGALS3	Galectin. (273 aa)
	FCGBP	VWFD domain-containing protein. (324 aa)
	TGFBI	Transforming growth factor beta induced. (672 aa)
	LOC100920534	Uncharacterized protein. (638 aa)
	ELN	Uncharacterized protein. (578 aa)
	SMOC1	SPARC related modular calcium binding 1. (465 aa)
	SLIT2	Slit guidance ligand 2. (1375 aa)
	SMOC2	SPARC related modular calcium binding 2. (464 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	OLFML2A	Olfactomedin-like domain-containing protein. (569 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	G3VPX1_SARHA	ENSSHAP00000008456	ENSSHAP00000005226	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Uncharacterized protein.	0.510
BGN	DAG1	ENSSHAP00000005104	ENSSHAP00000019871	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Dystroglycan 1.	0.535
BGN	DCN	ENSSHAP00000005104	ENSSHAP00000007112	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Decorin; May affect the rate of fibrils formation.	0.776
BGN	G3VPX1_SARHA	ENSSHAP00000005104	ENSSHAP00000005226	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Uncharacterized protein.	0.627
BGN	GPC1	ENSSHAP00000005104	ENSSHAP00000017531	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.481
BGN	NID1	ENSSHAP00000005104	ENSSHAP00000008490	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Uncharacterized protein.	0.402
BGN	SPARC	ENSSHAP00000005104	ENSSHAP00000008424	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Secreted protein acidic and cysteine rich.	0.475
BGN	TGFBI	ENSSHAP00000005104	ENSSHAP00000004371	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Transforming growth factor beta induced.	0.438
DAG1	BGN	ENSSHAP00000019871	ENSSHAP00000005104	Dystroglycan 1.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.535
DAG1	G3VPX1_SARHA	ENSSHAP00000019871	ENSSHAP00000005226	Dystroglycan 1.	Uncharacterized protein.	0.882
DAG1	SLIT2	ENSSHAP00000019871	ENSSHAP00000021620	Dystroglycan 1.	Slit guidance ligand 2.	0.563
DCN	BGN	ENSSHAP00000007112	ENSSHAP00000005104	Decorin; May affect the rate of fibrils formation.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.776
DCN	ELN	ENSSHAP00000007112	ENSSHAP00000001267	Decorin; May affect the rate of fibrils formation.	Uncharacterized protein.	0.722
DCN	G3VPX1_SARHA	ENSSHAP00000007112	ENSSHAP00000005226	Decorin; May affect the rate of fibrils formation.	Uncharacterized protein.	0.587
DCN	GPC1	ENSSHAP00000007112	ENSSHAP00000017531	Decorin; May affect the rate of fibrils formation.	Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.519
DCN	SPARC	ENSSHAP00000007112	ENSSHAP00000008424	Decorin; May affect the rate of fibrils formation.	Secreted protein acidic and cysteine rich.	0.803
DCN	TGFBI	ENSSHAP00000007112	ENSSHAP00000004371	Decorin; May affect the rate of fibrils formation.	Transforming growth factor beta induced.	0.487
DCN	THBS1	ENSSHAP00000007112	ENSSHAP00000006651	Decorin; May affect the rate of fibrils formation.	Thrombospondin 1.	0.538
DCN	VTN	ENSSHAP00000007112	ENSSHAP00000014892	Decorin; May affect the rate of fibrils formation.	SMB domain-containing protein.	0.591
ELN	DCN	ENSSHAP00000001267	ENSSHAP00000007112	Uncharacterized protein.	Decorin; May affect the rate of fibrils formation.	0.722