STRINGSTRING
G3VAA5_SARHA G3VAA5_SARHA FUZ FUZ LOC100919701 LOC100919701 SCEL SCEL GPC3 GPC3 G3VDE6_SARHA G3VDE6_SARHA G3VDH5_SARHA G3VDH5_SARHA APC APC PRDM15-2 PRDM15-2 APOE APOE PRICKLE1 PRICKLE1 G3VG33_SARHA G3VG33_SARHA WNK1 WNK1 G3VHE0_SARHA G3VHE0_SARHA RBMS3 RBMS3 G3VHT6_SARHA G3VHT6_SARHA WNT10B WNT10B G3VIP7_SARHA G3VIP7_SARHA PRDM15 PRDM15 G3VJV4_SARHA G3VJV4_SARHA CYLD CYLD G3VKC2_SARHA G3VKC2_SARHA DKKL1 DKKL1 G3VLH1_SARHA G3VLH1_SARHA LATS2 LATS2 AXIN1 AXIN1 NLE1 NLE1 FRMD8 FRMD8 SNAI2 SNAI2 KREMEN1 KREMEN1 CAPRIN2 CAPRIN2 FZD6 FZD6 TLE5 TLE5 G3VQ29_SARHA G3VQ29_SARHA RECK RECK NOTCH1 NOTCH1 TMEM9 TMEM9 LMBR1L LMBR1L AXIN2 AXIN2 GSK3B GSK3B ATP6AP2 ATP6AP2 TBL1XR1 TBL1XR1 DLX5 DLX5 G3VU23_SARHA G3VU23_SARHA CTHRC1 CTHRC1 KANK1 KANK1 PRKN PRKN MCC MCC SFRP2 SFRP2 FRZB FRZB GLI1 GLI1 CSNK1G2 CSNK1G2 SOST SOST G3VY89_SARHA G3VY89_SARHA G3VYC2_SARHA G3VYC2_SARHA SOX13 SOX13 NRARP NRARP WNK2 WNK2 STK11 STK11 LOC100919354 LOC100919354 DDIT3 DDIT3 NFKB1 NFKB1 G3VZP2_SARHA G3VZP2_SARHA CSNK1D CSNK1D TMEM131L TMEM131L EDA EDA DAB2 DAB2 DAB2IP DAB2IP CHD8 CHD8 CTDNEP1 CTDNEP1 EGFR EGFR G3BP1 G3BP1 SOX10 SOX10 CTNNB1 CTNNB1 LOC100921186 LOC100921186 NKX2-5 NKX2-5 NOTUM NOTUM AMFR AMFR GID8 GID8 ILK ILK FZD4 FZD4 FERMT1 FERMT1 GLI3 GLI3 DRAXIN DRAXIN LRRK1 LRRK1 YAP1 YAP1 HDAC1 HDAC1 MAD2L2 MAD2L2 SOX7 SOX7 TLE1 TLE1 WNT11 WNT11 FGF2 FGF2 BTRC BTRC TMEM64 TMEM64 PIN1 PIN1 CTNNBIP1 CTNNBIP1 OTULINL OTULINL SCYL2 SCYL2 RSPO2 RSPO2 UBAC2 UBAC2 G3WCC0_SARHA G3WCC0_SARHA SOX17 SOX17 G3WD07_SARHA G3WD07_SARHA BICC1 BICC1 OTULIN OTULIN G3WE11_SARHA G3WE11_SARHA STK4 STK4 TMEM198 TMEM198 G3WEN9_SARHA G3WEN9_SARHA TTC21B TTC21B RNF220 RNF220 SDHAF2 SDHAF2 USP8 USP8 USP34 USP34 LYPD6B LYPD6B MKS1 MKS1 HDAC2 HDAC2 EGR1 EGR1 PSEN1 PSEN1 IGFBP2 IGFBP2 PTK7 PTK7 TPBGL TPBGL IFT20 IFT20 RSPO1 RSPO1 TPBG TPBG G3WHD6_SARHA G3WHD6_SARHA AMER2 AMER2 USP47 USP47 G3WI92_SARHA G3WI92_SARHA LGR4 LGR4 APC2 APC2 LYPD6 LYPD6 CCNYL1 CCNYL1 DKK2 DKK2 DKK3 DKK3 G3WJZ8_SARHA G3WJZ8_SARHA COL1A1 COL1A1 TNN TNN NKD2 NKD2 LZTS2 LZTS2 CDK15 CDK15 RUVBL1 RUVBL1 KPNA1 KPNA1 PPM1A PPM1A G3WNZ0_SARHA G3WNZ0_SARHA TMEM88 TMEM88 PTPRO PTPRO ANKRD6 ANKRD6 DKK1 DKK1 NPHP3 NPHP3 CAV1 CAV1 JADE1 JADE1 SFRP1 SFRP1 G3WRN2_SARHA G3WRN2_SARHA GREM1 GREM1 CTNND1 CTNND1 G3WTU0_SARHA G3WTU0_SARHA XIAP XIAP CCNY CCNY ADGRA2 ADGRA2 LRRK2 LRRK2 LRP4 LRP4 VCP VCP TLE3 TLE3 TMEM170B TMEM170B WLS WLS TCF7L2 TCF7L2 PTPRU PTPRU ARNTL ARNTL LATS1 LATS1 TBL1X TBL1X SFRP4 SFRP4 JRK JRK UBR5 UBR5 TLE4 TLE4 CDK14 CDK14 SFRP5 SFRP5 SOX9 SOX9 HHEX HHEX NPHP4 NPHP4 SIAH2 SIAH2 DACT1 DACT1 RSPO3 RSPO3 PPM1B PPM1B CSNK1G1 CSNK1G1 CCAR2 CCAR2 RNF146 RNF146 TNKS2 TNKS2 SLC9A3R1 SLC9A3R1 NKD1 NKD1 G3X3V6_SARHA G3X3V6_SARHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G3VAA5_SARHAUncharacterized protein. (755 aa)
FUZUncharacterized protein. (264 aa)
LOC100919701Uncharacterized protein. (127 aa)
SCELSciellin. (736 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (449 aa)
G3VDE6_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
G3VDH5_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (387 aa)
APCUncharacterized protein. (2704 aa)
PRDM15-2SET domain-containing protein. (299 aa)
APOEUncharacterized protein. (256 aa)
PRICKLE1Prickle planar cell polarity protein 1. (826 aa)
G3VG33_SARHAHist_deacetyl domain-containing protein. (330 aa)
WNK1WNK lysine deficient protein kinase 1. (2151 aa)
G3VHE0_SARHAOTU domain-containing protein. (346 aa)
RBMS3RNA binding motif single stranded interacting protein 3. (361 aa)
G3VHT6_SARHAAPC_N_CC domain-containing protein. (147 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
G3VIP7_SARHARING-type domain-containing protein. (740 aa)
PRDM15Uncharacterized protein. (826 aa)
G3VJV4_SARHAUncharacterized protein. (246 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (936 aa)
G3VKC2_SARHAUncharacterized protein. (728 aa)
DKKL1Uncharacterized protein. (195 aa)
G3VLH1_SARHAWD_REPEATS_REGION domain-containing protein. (732 aa)
LATS2Large tumor suppressor kinase 2. (1120 aa)
AXIN1Axin 1. (875 aa)
NLE1Notchless homolog 1. (485 aa)
FRMD8FERM domain containing 8. (451 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
KREMEN1Kringle containing transmembrane protein 1. (350 aa)
CAPRIN2Caprin family member 2. (1067 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (718 aa)
TLE5TLE family member 5, transcriptional modulator. (171 aa)
G3VQ29_SARHAProtein kinase domain-containing protein. (392 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (941 aa)
NOTCH1Notch receptor 1. (2672 aa)
TMEM9Transmembrane protein 9. (122 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (491 aa)
AXIN2Axin 2. (837 aa)
GSK3BGlycogen synthase kinase 3 beta. (259 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (353 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (516 aa)
DLX5Distal-less homeobox 5. (163 aa)
G3VU23_SARHAHist_deacetyl domain-containing protein. (260 aa)
CTHRC1Collagen triple helix repeat containing 1. (247 aa)
KANK1KN motif and ankyrin repeat domains 1. (1343 aa)
PRKNUbiquitin-like domain-containing protein. (54 aa)
MCCMCC regulator of WNT signaling pathway. (722 aa)
SFRP2Secreted frizzled related protein 2. (238 aa)
FRZBFrizzled related protein. (321 aa)
GLI1GLI family zinc finger 1. (1097 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (415 aa)
SOSTSclerostin. (212 aa)
G3VY89_SARHAUncharacterized protein. (859 aa)
G3VYC2_SARHAUncharacterized protein. (172 aa)
SOX13SRY-box transcription factor 13. (617 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
WNK2OSR1_C domain-containing protein. (1802 aa)
STK11Serine/threonine kinase 11. (252 aa)
LOC100919354Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (325 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (170 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
G3VZP2_SARHAUncharacterized protein. (390 aa)
CSNK1DCasein kinase 1 delta. (391 aa)
TMEM131LTransmembrane 131 like. (1474 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (216 aa)
DAB2PID domain-containing protein. (457 aa)
DAB2IPDAB2 interacting protein. (783 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2594 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (245 aa)
EGFRReceptor protein-tyrosine kinase. (1152 aa)
G3BP1G3BP stress granule assembly factor 1. (467 aa)
SOX10SRY-box transcription factor 10. (365 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC100921186DUF4203 domain-containing protein. (349 aa)
NKX2-5Homeobox domain-containing protein. (320 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (517 aa)
AMFRAutocrine motility factor receptor. (620 aa)
GID8GID complex subunit 8 homolog. (228 aa)
ILKIntegrin linked kinase. (452 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
FERMT1Fermitin family member 1. (677 aa)
GLI3GLI family zinc finger 3. (1583 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (338 aa)
LRRK1Leucine rich repeat kinase 1. (1960 aa)
YAP1Yes associated protein 1. (501 aa)
HDAC1Hist_deacetyl domain-containing protein. (323 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (159 aa)
SOX7Uncharacterized protein. (387 aa)
TLE1TLE family member 1, transcriptional corepressor. (781 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (634 aa)
TMEM64Transmembrane protein 64. (334 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (159 aa)
CTNNBIP1Catenin beta interacting protein 1. (63 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (338 aa)
SCYL2Protein kinase domain-containing protein. (335 aa)
RSPO2R-spondin 2. (243 aa)
UBAC2UBA domain containing 2. (343 aa)
G3WCC0_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (340 aa)
SOX17Uncharacterized protein. (399 aa)
G3WD07_SARHAUncharacterized protein. (415 aa)
BICC1BicC family RNA binding protein 1. (948 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (360 aa)
G3WE11_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (330 aa)
STK4Serine/threonine kinase 4. (487 aa)
TMEM198Transmembrane protein 198. (361 aa)
G3WEN9_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (318 aa)
TTC21BTetratricopeptide repeat domain 21B. (1315 aa)
RNF220RING-type domain-containing protein. (353 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1103 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3558 aa)
LYPD6BLY6/PLAUR domain containing 6B. (189 aa)
MKS1MKS transition zone complex subunit 1. (563 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (473 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (528 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
IGFBP2Thyroglobulin type-1 domain-containing protein. (173 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1062 aa)
TPBGLTrophoblast glycoprotein like. (333 aa)
IFT20Intraflagellar transport 20. (133 aa)
RSPO1R-spondin 1. (262 aa)
TPBGTrophoblast glycoprotein. (437 aa)
G3WHD6_SARHAUncharacterized protein. (525 aa)
AMER2APC membrane recruitment protein 2. (680 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1354 aa)
G3WI92_SARHAPoly [ADP-ribose] polymerase. (1090 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (889 aa)
APC2APC regulator of WNT signaling pathway 2. (2196 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
CCNYL1Cyclin Y like 1; Belongs to the cyclin family. (291 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (272 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (377 aa)
G3WJZ8_SARHAUncharacterized protein. (210 aa)
COL1A1Collagen type I alpha 1 chain. (1475 aa)
TNNTenascin N. (1243 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (457 aa)
LZTS2Leucine zipper tumor suppressor 2. (675 aa)
CDK15Cyclin dependent kinase 15; Belongs to the protein kinase superfamily. (433 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (409 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (547 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
G3WNZ0_SARHAUncharacterized protein. (290 aa)
TMEM88Transmembrane protein 88. (163 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1204 aa)
ANKRD6Ankyrin repeat domain 6. (731 aa)
DKK1Uncharacterized protein. (138 aa)
NPHP3TPR_REGION domain-containing protein. (1283 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (188 aa)
JADE1Jade family PHD finger 1. (665 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
G3WRN2_SARHAProtein kinase domain-containing protein. (295 aa)
GREM1Gremlin. (184 aa)
CTNND1Catenin delta 1. (938 aa)
G3WTU0_SARHAUncharacterized protein. (128 aa)
XIAPX-linked inhibitor of apoptosis. (492 aa)
CCNYCyclin Y; Belongs to the cyclin family. (253 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1225 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
LRP4LDL receptor related protein 4. (1911 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (802 aa)
TLE3TLE family member 3, transcriptional corepressor. (772 aa)
TMEM170BTransmembrane protein 170B. (102 aa)
WLSWnt ligand secretion mediator. (541 aa)
TCF7L2Transcription factor 7 like 2. (471 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1477 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
LATS1Large tumor suppressor kinase 1. (1134 aa)
TBL1XUncharacterized protein. (512 aa)
SFRP4NTR domain-containing protein. (137 aa)
JRKJrk helix-turn-helix protein. (570 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2802 aa)
TLE4TLE family member 4, transcriptional corepressor. (595 aa)
CDK14Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (269 aa)
SFRP5Secreted frizzled related protein 5. (259 aa)
SOX9SRY-box transcription factor 9. (552 aa)
HHEXHomeobox domain-containing protein. (142 aa)
NPHP4Nephrocystin 4. (1441 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (264 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (866 aa)
RSPO3R-spondin 3. (279 aa)
PPM1BPPM-type phosphatase domain-containing protein. (479 aa)
CSNK1G1Casein kinase 1 gamma 1. (387 aa)
CCAR2Cell cycle and apoptosis regulator 2. (960 aa)
RNF146Ring finger protein 146. (353 aa)
TNKS2Tankyrase 2. (1104 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (343 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (376 aa)
G3X3V6_SARHAUncharacterized protein. (231 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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