(27 nodes) Neuron cellular homeostasis network (Sarcophilus harrisii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	HEXB	Hexosaminidase subunit beta. (458 aa)
	G3VDW8_SARHA	Calx-beta domain-containing protein. (563 aa)
	APP	Amyloid beta precursor protein. (750 aa)
	G3VHD1_SARHA	Uncharacterized protein. (272 aa)
	DISC1	Uncharacterized protein. (366 aa)
	CA7	Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
	CALB1	Calbindin 1. (261 aa)
	FGGY	FGGY carbohydrate kinase domain containing. (552 aa)
	ATP2B3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1253 aa)
	PRKN	Ubiquitin-like domain-containing protein. (54 aa)
	CHRNA1	Cholinergic receptor nicotinic alpha 1 subunit. (472 aa)
	TMEM175	Uncharacterized protein. (406 aa)
	G3W1V4_SARHA	Uncharacterized protein. (114 aa)
	CHMP2B	Charged multivesicular body protein 2B. (212 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
	BAP1	BRCA1 associated protein 1. (723 aa)
	SCGN	Secretagogin, EF-hand calcium binding protein. (276 aa)
	CALB2	Calbindin 2. (196 aa)
	G3W731_SARHA	Uncharacterized protein. (178 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
	MAP1A	Microtubule associated protein 1A. (2878 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	IMMT	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (703 aa)
	CX3CL1	SCY domain-containing protein. (417 aa)
	DCTN1	CAP-Gly domain-containing protein. (1283 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1209 aa)
	TYRO3	TYRO3 protein tyrosine kinase. (841 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	DISC1	ENSSHAP00000002408	ENSSHAP00000002873	Amyloid beta precursor protein.	Uncharacterized protein.	0.428
APP	G3W731_SARHA	ENSSHAP00000002408	ENSSHAP00000011236	Amyloid beta precursor protein.	Uncharacterized protein.	0.428
APP	PRKN	ENSSHAP00000002408	ENSSHAP00000006978	Amyloid beta precursor protein.	Ubiquitin-like domain-containing protein.	0.420
APP	PSEN1	ENSSHAP00000002408	ENSSHAP00000014543	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.950
BAP1	FGGY	ENSSHAP00000011119	ENSSHAP00000005942	BRCA1 associated protein 1.	FGGY carbohydrate kinase domain containing.	0.475
DISC1	APP	ENSSHAP00000002873	ENSSHAP00000002408	Uncharacterized protein.	Amyloid beta precursor protein.	0.428
DISC1	G3W731_SARHA	ENSSHAP00000002873	ENSSHAP00000011236	Uncharacterized protein.	Uncharacterized protein.	0.697
FGGY	BAP1	ENSSHAP00000005942	ENSSHAP00000011119	FGGY carbohydrate kinase domain containing.	BRCA1 associated protein 1.	0.475
G3W731_SARHA	APP	ENSSHAP00000011236	ENSSHAP00000002408	Uncharacterized protein.	Amyloid beta precursor protein.	0.428
G3W731_SARHA	DISC1	ENSSHAP00000011236	ENSSHAP00000002873	Uncharacterized protein.	Uncharacterized protein.	0.697
PRKN	APP	ENSSHAP00000006978	ENSSHAP00000002408	Ubiquitin-like domain-containing protein.	Amyloid beta precursor protein.	0.420
PSEN1	APP	ENSSHAP00000014543	ENSSHAP00000002408	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta precursor protein.	0.950