(20 nodes) Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress network (Sarcophilus harrisii)

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Your Input:
	TMEM117	Transmembrane protein 117. (517 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2696 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1255 aa)
	PML	Uncharacterized protein. (376 aa)
	DAB2IP	DAB2 interacting protein. (783 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (170 aa)
	ERN2	Endoplasmic reticulum to nucleus signaling 2. (900 aa)
	BAG6	BCL2 associated athanogene 6. (1131 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	BAK1	BCL2 antagonist/killer 1. (208 aa)
	PDX1	Homeobox domain-containing protein. (287 aa)
	BCL2	BCL2 apoptosis regulator. (227 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (175 aa)
	SELENOK	Selenoprotein K. (90 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (580 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
	QRICH1	Glutamine rich 1. (776 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (922 aa)
	ATF4	Activating transcription factor 4. (344 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1385 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	APAF1	ENSSHAP00000018848	ENSSHAP00000013128	Apoptosis inducing factor mitochondria associated 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.528
APAF1	AIFM1	ENSSHAP00000013128	ENSSHAP00000018848	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis inducing factor mitochondria associated 1.	0.528
APAF1	BAK1	ENSSHAP00000013128	ENSSHAP00000005850	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.633
APAF1	BCL2	ENSSHAP00000013128	ENSSHAP00000020974	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.903
APAF1	TP53	ENSSHAP00000013128	ENSSHAP00000018268	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.733
ATF4	CHAC1	ENSSHAP00000016539	ENSSHAP00000019186	Activating transcription factor 4.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.660
ATF4	DDIT3	ENSSHAP00000016539	ENSSHAP00000008453	Activating transcription factor 4.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.984
ATF4	ERN1	ENSSHAP00000016539	ENSSHAP00000016597	Activating transcription factor 4.	Endoplasmic reticulum to nucleus signaling 1.	0.436
ATF4	TRIB3	ENSSHAP00000016539	ENSSHAP00000005935	Activating transcription factor 4.	Tribbles pseudokinase 3.	0.766
BAK1	APAF1	ENSSHAP00000005850	ENSSHAP00000013128	BCL2 antagonist/killer 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.633
BAK1	BCL2	ENSSHAP00000005850	ENSSHAP00000020974	BCL2 antagonist/killer 1.	BCL2 apoptosis regulator.	0.982
BAK1	ERN1	ENSSHAP00000005850	ENSSHAP00000016597	BCL2 antagonist/killer 1.	Endoplasmic reticulum to nucleus signaling 1.	0.410
BAK1	TP53	ENSSHAP00000005850	ENSSHAP00000018268	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.973
BCL2	APAF1	ENSSHAP00000020974	ENSSHAP00000013128	BCL2 apoptosis regulator.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.903
BCL2	BAK1	ENSSHAP00000020974	ENSSHAP00000005850	BCL2 apoptosis regulator.	BCL2 antagonist/killer 1.	0.982
BCL2	DDIT3	ENSSHAP00000020974	ENSSHAP00000008453	BCL2 apoptosis regulator.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.939
BCL2	ERN1	ENSSHAP00000020974	ENSSHAP00000016597	BCL2 apoptosis regulator.	Endoplasmic reticulum to nucleus signaling 1.	0.408
BCL2	ITPR1	ENSSHAP00000020974	ENSSHAP00000014834	BCL2 apoptosis regulator.	Inositol 1,4,5-trisphosphate receptor type 1.	0.730
BCL2	TP53	ENSSHAP00000020974	ENSSHAP00000018268	BCL2 apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.989
CHAC1	ATF4	ENSSHAP00000019186	ENSSHAP00000016539	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Activating transcription factor 4.	0.660