(86 nodes) Extracellular exosome network (Sarcophilus harrisii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
	ARMC3	Armadillo repeat containing 3. (877 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	AOC1	Amine oxidase. (761 aa)
	S100Z	Protein S100; Belongs to the S-100 family. (99 aa)
	PTER	Phosphotriesterase related. (349 aa)
	ACY1	M20_dimer domain-containing protein. (499 aa)
	TSTA3	Epimerase domain-containing protein. (282 aa)
	SH3BGRL	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (114 aa)
	G3VWV7_SARHA	Uncharacterized protein. (548 aa)
	CCDC105	Coiled-coil domain containing 105. (483 aa)
	RENBP	Renin binding protein. (383 aa)
	LOC105748988	IF rod domain-containing protein; Belongs to the intermediate filament family. (459 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	TFRC	Transferrin receptor. (770 aa)
	ADAM15	ADAM metallopeptidase domain 15. (865 aa)
	PLAA	Phospholipase A2 activating protein. (799 aa)
	BAG6	BCL2 associated athanogene 6. (1131 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (400 aa)
	TTC38	Tetratricopeptide repeat domain 38. (463 aa)
	SCRN2	Secernin 2. (432 aa)
	GARS1	Glycyl-tRNA synthetase. (681 aa)
	CD81	Tetraspanin. (214 aa)
	GPRC5C	G protein-coupled receptor class C group 5 member C. (444 aa)
	C1H16orf89	Uncharacterized protein. (350 aa)
	G3VHQ7_SARHA	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (145 aa)
	G3VH15_SARHA	ILEI domain-containing protein. (226 aa)
	G3VFD3_SARHA	BcrAD_BadFG domain-containing protein. (311 aa)
	G3VD27_SARHA	BRO1 domain-containing protein. (811 aa)
	C8G	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (201 aa)
	CYSRT1	Uncharacterized protein. (134 aa)
	FN1	Fibronectin 1. (2302 aa)
	BPGM	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (658 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (862 aa)
	SRI	Sorcin. (199 aa)
	CPVL	Carboxypeptidase vitellogenic like; Belongs to the peptidase S10 family. (475 aa)
	ANXA1	Annexin. (346 aa)
	GPRC5D	G protein-coupled receptor class C group 5 member D. (339 aa)
	GPRC5A	G protein-coupled receptor class C group 5 member A. (360 aa)
	PKHD1	PA14 domain-containing protein. (1684 aa)
	LAMP2	Lysosomal associated membrane protein 2. (416 aa)
	SMS	Spermine synthase. (362 aa)
	NSUN2	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (725 aa)
	HGD	Homogentisate 1,2-dioxygenase. (439 aa)
	LOC100915370	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1923 aa)
	SLC12A1	Solute carrier family 12 member 1. (1129 aa)
	CD47	CD47 molecule. (306 aa)
	IGFBP2	Thyroglobulin type-1 domain-containing protein. (173 aa)
	SLC12A3	Solute carrier family 12 member 3. (1035 aa)
	ARL15	ADP ribosylation factor like GTPase 15. (184 aa)
	SDCBP	Syndecan binding protein. (298 aa)
	ANPEP	Aminopeptidase. (976 aa)
	SLC26A4	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (728 aa)
	HBS1L	HBS1 like translational GTPase. (685 aa)
	ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group). (562 aa)
	CALCOCO2	SKICH domain-containing protein. (192 aa)
	G3WKW4_SARHA	AMP_N domain-containing protein. (117 aa)
	CD9	Tetraspanin. (230 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (839 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
	YBX1	Y-box binding protein 1. (297 aa)
	PEPD	Peptidase_M24 domain-containing protein; Belongs to the peptidase M24B family. (171 aa)
	XPNPEP2	X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. (674 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (618 aa)
	BHMT	Betaine--homocysteine S-methyltransferase. (408 aa)
	FAH	Fumarylacetoacetase. (420 aa)
	BHMT2	Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa)
	FAM3C	ILEI domain-containing protein. (225 aa)
	TAX1BP1	Tax1 binding protein 1. (803 aa)
	TSG101	Tumor susceptibility 101. (359 aa)
	KIF12	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (696 aa)
	BEND7	BEN domain containing 7. (319 aa)
	ITGA2B	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1057 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4232 aa)
	UFC1	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
	MYOC	Myocilin. (498 aa)
	SORD	Sorbitol dehydrogenase. (358 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (716 aa)
	ARHGAP23	Rho GTPase activating protein 23. (1057 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (926 aa)
	PROM1	Prominin 1. (860 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (270 aa)
	GPRC5B	G protein-coupled receptor class C group 5 member B. (461 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	DICER1	ENSSHAP00000011147	ENSSHAP00000014131	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.980
AGO2	YBX1	ENSSHAP00000011147	ENSSHAP00000017000	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Y-box binding protein 1.	0.579
ANPEP	TFRC	ENSSHAP00000015332	ENSSHAP00000006756	Aminopeptidase.	Transferrin receptor.	0.472
ANPEP	XPNPEP2	ENSSHAP00000015332	ENSSHAP00000017261	Aminopeptidase.	X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family.	0.419
ANXA1	CD81	ENSSHAP00000011687	ENSSHAP00000003383	Annexin.	Tetraspanin.	0.538
ANXA1	CD9	ENSSHAP00000011687	ENSSHAP00000016156	Annexin.	Tetraspanin.	0.505
ANXA1	TSG101	ENSSHAP00000011687	ENSSHAP00000017982	Annexin.	Tumor susceptibility 101.	0.540
AOC1	SORD	ENSSHAP00000008942	ENSSHAP00000020413	Amine oxidase.	Sorbitol dehydrogenase.	0.460
BHMT	BHMT2	ENSSHAP00000017487	ENSSHAP00000017617	Betaine--homocysteine S-methyltransferase.	Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism.	0.901
BHMT2	BHMT	ENSSHAP00000017617	ENSSHAP00000017487	Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism.	Betaine--homocysteine S-methyltransferase.	0.901
CCDC105	DICER1	ENSSHAP00000007108	ENSSHAP00000014131	Coiled-coil domain containing 105.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.551
CCDC105	HBS1L	ENSSHAP00000007108	ENSSHAP00000015857	Coiled-coil domain containing 105.	HBS1 like translational GTPase.	0.526
CCDC105	TSTA3	ENSSHAP00000007108	ENSSHAP00000007903	Coiled-coil domain containing 105.	Epimerase domain-containing protein.	0.538
CD47	CD9	ENSSHAP00000014426	ENSSHAP00000016156	CD47 molecule.	Tetraspanin.	0.418
CD81	ANXA1	ENSSHAP00000003383	ENSSHAP00000011687	Tetraspanin.	Annexin.	0.538
CD81	CD9	ENSSHAP00000003383	ENSSHAP00000016156	Tetraspanin.	Tetraspanin.	0.840
CD81	G3VD27_SARHA	ENSSHAP00000003383	ENSSHAP00000001081	Tetraspanin.	BRO1 domain-containing protein.	0.438
CD81	HSPA4	ENSSHAP00000003383	ENSSHAP00000016232	Tetraspanin.	Heat shock protein family A (Hsp70) member 4.	0.576
CD81	SDCBP	ENSSHAP00000003383	ENSSHAP00000015028	Tetraspanin.	Syndecan binding protein.	0.553
CD81	TSG101	ENSSHAP00000003383	ENSSHAP00000017982	Tetraspanin.	Tumor susceptibility 101.	0.694