STRINGSTRING
ACAA2 ACAA2 NDUFA13 NDUFA13 CLUL1 CLUL1 TPT1 TPT1 G3VG33_SARHA G3VG33_SARHA FXN FXN FAIM FAIM ZC3HC1 ZC3HC1 RELA RELA OPA1 OPA1 TXNDC12 TXNDC12 YBX3 YBX3 GRINA GRINA YJEFN3 YJEFN3 CX3CR1 CX3CR1 NLE1 NLE1 SNAI2 SNAI2 LGALS3 LGALS3 PLAUR PLAUR CAAP1 CAAP1 COL2A1 COL2A1 G3VQ70_SARHA G3VQ70_SARHA GCLM GCLM BIRC6 BIRC6 BAK1 BAK1 SERPINE1 SERPINE1 CDKN2D CDKN2D G3VTR0_SARHA G3VTR0_SARHA G3VU23_SARHA G3VU23_SARHA MMP9 MMP9 RFFL RFFL PRKN PRKN SELENOS SELENOS G3VW97_SARHA G3VW97_SARHA BDKRB2 BDKRB2 SFRP2 SFRP2 GHITM GHITM MARCHF7 MARCHF7 CLU CLU MUC1 MUC1 ZMYND11 ZMYND11 PEA15 PEA15 HTT HTT SGK3 SGK3 PINK1 PINK1 IGF1 IGF1 EPO EPO CTNNB1 CTNNB1 RB1CC1 RB1CC1 UNC5B UNC5B IL1B IL1B G3W4K4_SARHA G3W4K4_SARHA ITGAV ITGAV AGAP2 AGAP2 PHIP PHIP PELI3 PELI3 BID BID SLC35F6 SLC35F6 EYA1 EYA1 HDAC1 HDAC1 G3W8Q5_SARHA G3W8Q5_SARHA HYOU1 HYOU1 IVNS1ABP IVNS1ABP TMBIM6 TMBIM6 MPV17L MPV17L TNFAIP3 TNFAIP3 NME5 NME5 AATF AATF PTPN2 PTPN2 NANOS3 NANOS3 XBP1 XBP1 MCL1 MCL1 NOL3 NOL3 SNAI1 SNAI1 FAIM2 FAIM2 BRCA1 BRCA1 RTKN2 RTKN2 G3WEU9_SARHA G3WEU9_SARHA KDM1A KDM1A G3WF29_SARHA G3WF29_SARHA SCG2 SCG2 HIF1A HIF1A HDAC2 HDAC2 TMEM161A TMEM161A PSEN1 PSEN1 STRADA STRADA HSPB1 HSPB1 SIRT1 SIRT1 HERPUD1 HERPUD1 ING2 ING2 USP47 USP47 BMI1 BMI1 NR4A2 NR4A2 EYA4 EYA4 SH3RF1 SH3RF1 PSMD10 PSMD10 SLC25A31 SLC25A31 PRELID1 PRELID1 MAPK7 MAPK7 BCL2L1 BCL2L1 LMNA LMNA CFLAR CFLAR FGG FGG RB1 RB1 TRIM32 TRIM32 FGB FGB CREB3 CREB3 PARL PARL HELLS HELLS G3VBM8_SARHA G3VBM8_SARHA MAP2K5 MAP2K5 RIPK1 RIPK1 ELL3 ELL3 TRAP1 TRAP1 ACKR3 ACKR3 SOD2 SOD2 BCL2L2 BCL2L2 TMEM14A TMEM14A CX3CL1 CX3CL1 QARS1 QARS1 NRP1 NRP1 CREB3L1 CREB3L1 EYA3 EYA3 URI1 URI1 HGF HGF TERT TERT PARK7 PARK7 BAG5 BAG5 RPS6KB1 RPS6KB1 PTGS2 PTGS2 WNT4 WNT4 ITPRIP ITPRIP TMBIM1 TMBIM1 LRRK2 LRRK2 AR AR TGFBR1 TGFBR1 RNF34 RNF34 WFS1 WFS1 GCLC GCLC VAX1 VAX1 PPIF PPIF EYA2 EYA2 GDNF GDNF ITGA6 ITGA6 PCGF2 PCGF2 ACVR1 ACVR1 NDUFS3 NDUFS3 BCL2 BCL2 PDX1 PDX1 ITPRIPL2 ITPRIPL2 DDIAS DDIAS PIK3CB PIK3CB GATA1 GATA1 BOK BOK IL19 IL19 NFE2L2 NFE2L2 SIAH2 SIAH2 CCAR2 CCAR2 ATAD5 ATAD5 HMOX1 HMOX1 SYVN1 SYVN1 SLC25A4 SLC25A4 G3VDN6_SARHA G3VDN6_SARHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (166 aa)
CLUL1Clusterin; Belongs to the clusterin family. (473 aa)
TPT1TCTP domain-containing protein; Belongs to the TCTP family. (139 aa)
G3VG33_SARHAHist_deacetyl domain-containing protein. (330 aa)
FXNUncharacterized protein. (221 aa)
FAIMFas apoptotic inhibitory molecule. (202 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (465 aa)
RELARELA proto-oncogene, NF-kB subunit. (483 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (872 aa)
TXNDC12Thioredoxin domain containing 12. (178 aa)
YBX3Y-box binding protein 3. (297 aa)
GRINAGlutamate ionotropic receptor NMDA type subunit associated protein 1; Belongs to the BI1 family. (344 aa)
YJEFN3YjeF N-terminal domain-containing protein. (243 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
NLE1Notchless homolog 1. (485 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
LGALS3Galectin. (273 aa)
PLAURUncharacterized protein. (246 aa)
CAAP1Caspase activity and apoptosis inhibitor 1. (311 aa)
COL2A1Collagen type II alpha 1 chain. (1491 aa)
G3VQ70_SARHAUncharacterized protein. (696 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (273 aa)
BIRC6Baculoviral IAP repeat containing 6. (4753 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (400 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (167 aa)
G3VTR0_SARHAUncharacterized protein. (216 aa)
G3VU23_SARHAHist_deacetyl domain-containing protein. (260 aa)
MMP9Matrix metallopeptidase 9. (717 aa)
RFFLUncharacterized protein. (379 aa)
PRKNUbiquitin-like domain-containing protein. (54 aa)
SELENOSSelenoprotein S. (193 aa)
G3VW97_SARHAThiolase_N domain-containing protein. (297 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (389 aa)
SFRP2Secreted frizzled related protein 2. (238 aa)
GHITMGrowth hormone inducible transmembrane protein. (352 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (709 aa)
CLUClusterin; Belongs to the clusterin family. (405 aa)
MUC1SEA domain-containing protein. (523 aa)
ZMYND11Zinc finger MYND-type containing 11. (602 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)
HTTHuntingtin. (3065 aa)
SGK3Serum/glucocorticoid regulated kinase family member 3; Belongs to the protein kinase superfamily. (436 aa)
PINK1PTEN induced kinase 1. (453 aa)
IGF1Insulin like growth factor 1. (130 aa)
EPOErythropoietin. (191 aa)
CTNNB1Catenin beta 1. (781 aa)
RB1CC1RB1 inducible coiled-coil 1. (1592 aa)
UNC5BUnc-5 netrin receptor B. (1004 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
G3W4K4_SARHAUncharacterized protein. (154 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1013 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1167 aa)
PHIPPleckstrin homology domain interacting protein. (1780 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (464 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
SLC35F6Solute carrier family 35 member F6; May play a role as a nucleotide-sugar transporter. (349 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
HDAC1Hist_deacetyl domain-containing protein. (323 aa)
G3W8Q5_SARHAUncharacterized protein. (148 aa)
HYOU1Hypoxia up-regulated 1. (1016 aa)
IVNS1ABPInfluenza virus NS1A binding protein. (645 aa)
TMBIM6Uncharacterized protein; Belongs to the BI1 family. (237 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (190 aa)
TNFAIP3TNF alpha induced protein 3. (792 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (213 aa)
AATFApoptosis antagonizing transcription factor. (504 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (420 aa)
NANOS3Nanos-type domain-containing protein; Belongs to the nanos family. (132 aa)
XBP1BZIP domain-containing protein. (308 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (262 aa)
NOL3CARD domain-containing protein. (215 aa)
SNAI1Snail family transcriptional repressor 1. (259 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1410 aa)
RTKN2Rhotekin 2. (511 aa)
G3WEU9_SARHATCTP domain-containing protein; Belongs to the TCTP family. (94 aa)
KDM1ALysine demethylase 1A. (562 aa)
G3WF29_SARHABHLH domain-containing protein. (221 aa)
SCG2Secretogranin II. (623 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (473 aa)
TMEM161ATransmembrane protein 161A. (467 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
STRADASTE20 related adaptor alpha. (431 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (218 aa)
SIRT1Sirtuin 1. (597 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (475 aa)
ING2Inhibitor of growth protein. (283 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1354 aa)
BMI1RING-type domain-containing protein. (326 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (609 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (619 aa)
SH3RF1SH3 domain containing ring finger 1. (598 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (241 aa)
PRELID1PRELI domain containing 1. (219 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (783 aa)
BCL2L1BCL2 like 1. (227 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (527 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (496 aa)
FGGFibrinogen gamma chain. (443 aa)
RB1RB transcriptional corepressor 1. (848 aa)
TRIM32Tripartite motif containing 32. (650 aa)
FGBFibrinogen beta chain. (494 aa)
CREB3BZIP domain-containing protein. (370 aa)
PARLRhomboid domain-containing protein. (393 aa)
HELLSHelicase, lymphoid specific. (842 aa)
G3VBM8_SARHAUncharacterized protein. (128 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (716 aa)
ELL3Uncharacterized protein. (418 aa)
TRAP1TNF receptor associated protein 1. (466 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (225 aa)
BCL2L2BCL2 like 2. (209 aa)
TMEM14ATransmembrane protein 14A. (107 aa)
CX3CL1SCY domain-containing protein. (417 aa)
QARS1Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (738 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (857 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (521 aa)
URI1URI1 prefoldin like chaperone. (474 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (761 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1154 aa)
PARK7Parkinsonism associated deglycase. (192 aa)
BAG5BCL2 associated athanogene 5. (447 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (527 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (609 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (264 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (549 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (301 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
ARUncharacterized protein. (388 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (475 aa)
RNF34Ring finger protein 34. (395 aa)
WFS1Wolframin ER transmembrane glycoprotein. (872 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (648 aa)
VAX1Ventral anterior homeobox 1. (327 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (190 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (539 aa)
GDNFGlial cell derived neurotrophic factor. (206 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1080 aa)
PCGF2Polycomb group ring finger 2. (327 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (187 aa)
BCL2BCL2 apoptosis regulator. (227 aa)
PDX1Homeobox domain-containing protein. (287 aa)
ITPRIPL2ITPRIP like 2. (534 aa)
DDIASRep_fac-A_C domain-containing protein. (1015 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
GATA1Uncharacterized protein. (331 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
IL19Uncharacterized protein. (180 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (598 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (264 aa)
CCAR2Cell cycle and apoptosis regulator 2. (960 aa)
ATAD5ATPase family AAA domain containing 5. (1793 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (283 aa)
SYVN1Synoviolin 1. (520 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
G3VDN6_SARHAUncharacterized protein. (151 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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