(20 nodes) Perikaryon network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FMR1	Fragile X mental retardation 1. (635 aa)
	G3VAB4_SARHA	Deacetylase sirtuin-type domain-containing protein. (212 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	APP	Amyloid beta precursor protein. (750 aa)
	EFNA2	Ephrin A2; Belongs to the ephrin family. (156 aa)
	DBNL	Drebrin like. (430 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (403 aa)
	RGS8	Regulator of G protein signaling 8. (180 aa)
	DIP2B	Disco interacting protein 2 homolog B. (1527 aa)
	KCNB1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (873 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
	KCND2	Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (372 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (373 aa)
	GAP43	Growth associated protein 43. (243 aa)
	KCNK1	Potassium channel subfamily K member. (336 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (508 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
	DHX36	DEAH-box helicase 36. (934 aa)
	MAPK8	Mitogen-activated protein kinase. (429 aa)
	RUFY3	RUN and FYVE domain containing 3. (676 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	FMR1	ENSSHAP00000002408	ENSSHAP00000015168	Amyloid beta precursor protein.	Fragile X mental retardation 1.	0.433
DIP2B	FMR1	ENSSHAP00000006732	ENSSHAP00000015168	Disco interacting protein 2 homolog B.	Fragile X mental retardation 1.	0.501
FMR1	APP	ENSSHAP00000015168	ENSSHAP00000002408	Fragile X mental retardation 1.	Amyloid beta precursor protein.	0.433
FMR1	DIP2B	ENSSHAP00000015168	ENSSHAP00000006732	Fragile X mental retardation 1.	Disco interacting protein 2 homolog B.	0.501
MAPK10	MAPK8	ENSSHAP00000002282	ENSSHAP00000020720	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.900
MAPK8	MAPK10	ENSSHAP00000020720	ENSSHAP00000002282	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.900