(46 nodes) Cytochrome P450, conserved site network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3WC89_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (515 aa)
	G3WG22_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
	LOC100922209	Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
	G3WHP6_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
	TBXAS1	Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (530 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (524 aa)
	G3WJU6_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (515 aa)
	G3WM46_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (450 aa)
	LOC100933766	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	G3WP56_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
	CYP2R1	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (516 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	LOC100927711	Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
	G3X2C6_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	CYP26A1	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (498 aa)
	G3VAN0_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (384 aa)
	LOC100926883	Uncharacterized protein. (319 aa)
	LOC100922742	Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
	G3VBS4_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
	G3VBW1_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (511 aa)
	G3VCH1_SARHA	Uncharacterized protein. (294 aa)
	G3VD26_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	G3VEL7_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (201 aa)
	LOC100916811	Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa)
	G3VF98_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
	G3VG21_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (407 aa)
	G3VG24_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
	LOC100925276	Uncharacterized protein; Belongs to the cytochrome P450 family. (517 aa)
	G3VI51_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (493 aa)
	G3VIA6_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (455 aa)
	G3VKK5_SARHA	Uncharacterized protein. (398 aa)
	LOC100925532	Uncharacterized protein; Belongs to the cytochrome P450 family. (511 aa)
	G3VNQ5_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa)
	LOC100916556	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (442 aa)
	G3VU56_SARHA	Uncharacterized protein. (529 aa)
	CYP2U1	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (536 aa)
	CYP4V2	Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (519 aa)
	CYP4F22	Cytochrome P450 family 4 subfamily F member 22. (367 aa)
	G3W116_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (517 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (443 aa)
	LOC100918011	Uncharacterized protein. (505 aa)
	CYP21A2	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (482 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	CYP17A1	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
	G3WBZ3_SARHA	Uncharacterized protein; Belongs to the cytochrome P450 family. (521 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP11A1	CYP17A1	ENSSHAP00000015660	ENSSHAP00000022045	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.944
CYP11A1	CYP21A2	ENSSHAP00000015660	ENSSHAP00000010993	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.	0.943
CYP11A1	CYP4V2	ENSSHAP00000015660	ENSSHAP00000007005	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family.	0.446
CYP11A1	LOC100927711	ENSSHAP00000015660	ENSSHAP00000018085	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.421
CYP17A1	CYP11A1	ENSSHAP00000022045	ENSSHAP00000015660	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.944
CYP17A1	CYP19A1	ENSSHAP00000022045	ENSSHAP00000017846	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.940
CYP17A1	CYP21A2	ENSSHAP00000022045	ENSSHAP00000010993	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.	0.923
CYP17A1	CYP4F22	ENSSHAP00000022045	ENSSHAP00000007974	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 4 subfamily F member 22.	0.581
CYP17A1	G3VI51_SARHA	ENSSHAP00000022045	ENSSHAP00000002855	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.916
CYP17A1	G3VKK5_SARHA	ENSSHAP00000022045	ENSSHAP00000003710	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.579
CYP17A1	G3W116_SARHA	ENSSHAP00000022045	ENSSHAP00000009121	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.945
CYP17A1	G3X2C6_SARHA	ENSSHAP00000022045	ENSSHAP00000021831	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.915
CYP17A1	LOC100918011	ENSSHAP00000022045	ENSSHAP00000009526	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.933
CYP17A1	LOC100927711	ENSSHAP00000022045	ENSSHAP00000018085	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.915
CYP17A1	LOC100933766	ENSSHAP00000022045	ENSSHAP00000016751	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.917
CYP19A1	CYP17A1	ENSSHAP00000017846	ENSSHAP00000022045	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.940
CYP19A1	G3VKK5_SARHA	ENSSHAP00000017846	ENSSHAP00000003710	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.576
CYP19A1	G3W116_SARHA	ENSSHAP00000017846	ENSSHAP00000009121	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.933
CYP19A1	G3WBZ3_SARHA	ENSSHAP00000017846	ENSSHAP00000012948	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.422
CYP19A1	LOC100918011	ENSSHAP00000017846	ENSSHAP00000009526	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.936