85 items (Sarcophilus harrisii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
	AP2A1	Adaptor related protein complex 2 subunit alpha 1. (741 aa)
	G3VB83_SARHA	Uncharacterized protein. (114 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (490 aa)
	G3VBY4_SARHA	KAP NTPase domain-containing protein. (439 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (194 aa)
	MAPK14	Mitogen-activated protein kinase. (366 aa)
	TRIB2	Protein kinase domain-containing protein. (219 aa)
	SHC3	SHC adaptor protein 3. (422 aa)
	PPP4R1	Protein phosphatase 4 regulatory subunit 1. (949 aa)
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (174 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (436 aa)
	MAPK15	Mitogen-activated protein kinase. (564 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (732 aa)
	RRAD	RRAD, Ras related glycolysis inhibitor and calcium channel regulator. (353 aa)
	G3VNC3_SARHA	Uncharacterized protein. (443 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
	VRK3	Protein kinase domain-containing protein. (214 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (258 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (937 aa)
	SHC1	SHC adaptor protein 1. (569 aa)
	DUSP7	Dual specificity phosphatase 7. (278 aa)
	ATF1	Uncharacterized protein. (313 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
	AP2B1	AP complex subunit beta. (946 aa)
	NAB2	NGFI-A binding protein 2. (519 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (733 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (181 aa)
	KRAS	KRAS proto-oncogene, GTPase. (198 aa)
	TRIB1	Tribbles pseudokinase 1. (369 aa)
	EGR2	Early growth response 2. (468 aa)
	G3VZY1_SARHA	Uncharacterized protein. (884 aa)
	MAPK1	Mitogen-activated protein kinase. (348 aa)
	G3W0V5_SARHA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (101 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1479 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
	PIK3R2	Uncharacterized protein. (738 aa)
	MAPK11	Mitogen-activated protein kinase. (327 aa)
	CSDE1	Cold shock domain containing E1. (816 aa)
	PPP4R4	Protein phosphatase 4 regulatory subunit 4. (790 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (745 aa)
	MAPK3	Mitogen-activated protein kinase. (375 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	SHC2	Uncharacterized protein. (479 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (185 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (528 aa)
	RPS6KA1	Non-specific serine/threonine protein kinase. (660 aa)
	RIT1	Ras like without CAAX 1. (183 aa)
	SRF	Serum response factor. (306 aa)
	RALB	RAS like proto-oncogene B. (209 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (284 aa)
	KIDINS220	Kinase D interacting substrate 220. (1773 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (783 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (808 aa)
	PPP2R1B	Protein phosphatase 2 scaffold subunit Abeta. (540 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	LYL1	LYL1 basic helix-loop-helix family member. (254 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1130 aa)
	G3WQQ3_SARHA	Uncharacterized protein. (1807 aa)
	SHC4	SHC adaptor protein 4. (538 aa)
	DNAL4	Dynein light chain. (104 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (716 aa)
	NAB1	NGFI-A binding protein 1. (497 aa)
	ANKRD60	ANK_REP_REGION domain-containing protein. (1039 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	NTRK1	Tyrosine-protein kinase receptor. (792 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1665 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (333 aa)
	ARC	Activity regulated cytoskeleton associated protein. (400 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1234 aa)
	FNBP4	Formin binding protein 4. (1004 aa)
	G3X039_SARHA	Serine/threonine-protein phosphatase. (322 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (307 aa)
	G3X1I3_SARHA	CHDCT2 domain-containing protein. (339 aa)
	GRB2	Growth factor receptor bound protein 2. (191 aa)
	EGR3	Early growth response 3. (277 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (395 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD60	G3X039_SARHA	ENSSHAP00000019242	ENSSHAP00000021044	ANK_REP_REGION domain-containing protein.	Serine/threonine-protein phosphatase.	0.655
ANKRD60	PPP2CA	ENSSHAP00000019242	ENSSHAP00000019590	ANK_REP_REGION domain-containing protein.	Serine/threonine-protein phosphatase.	0.655
ANKRD60	PPP2CB	ENSSHAP00000019242	ENSSHAP00000009829	ANK_REP_REGION domain-containing protein.	Serine/threonine-protein phosphatase.	0.655
ANKRD60	PPP4R4	ENSSHAP00000019242	ENSSHAP00000011592	ANK_REP_REGION domain-containing protein.	Protein phosphatase 4 regulatory subunit 4.	0.410
AP2A1	AP2A2	ENSSHAP00000000177	ENSSHAP00000005134	Adaptor related protein complex 2 subunit alpha 1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.625
AP2A1	AP2B1	ENSSHAP00000000177	ENSSHAP00000006054	Adaptor related protein complex 2 subunit alpha 1.	AP complex subunit beta.	0.951
AP2A1	AP2M1	ENSSHAP00000000177	ENSSHAP00000003094	Adaptor related protein complex 2 subunit alpha 1.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.997
AP2A1	CLTC	ENSSHAP00000000177	ENSSHAP00000019576	Adaptor related protein complex 2 subunit alpha 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.883
AP2A1	CLTCL1	ENSSHAP00000000177	ENSSHAP00000010155	Adaptor related protein complex 2 subunit alpha 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.883
AP2A1	DNAL4	ENSSHAP00000000177	ENSSHAP00000018376	Adaptor related protein complex 2 subunit alpha 1.	Dynein light chain.	0.461
AP2A1	G3W0V5_SARHA	ENSSHAP00000000177	ENSSHAP00000009060	Adaptor related protein complex 2 subunit alpha 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.800
AP2A1	GRB2	ENSSHAP00000000177	ENSSHAP00000021710	Adaptor related protein complex 2 subunit alpha 1.	Growth factor receptor bound protein 2.	0.612
AP2A1	SH3GL2	ENSSHAP00000000177	ENSSHAP00000005805	Adaptor related protein complex 2 subunit alpha 1.	SH3 domain containing GRB2 like 2, endophilin A1.	0.586
AP2A2	AP2A1	ENSSHAP00000005134	ENSSHAP00000000177	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Adaptor related protein complex 2 subunit alpha 1.	0.625
AP2A2	AP2B1	ENSSHAP00000005134	ENSSHAP00000006054	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.979
AP2A2	AP2M1	ENSSHAP00000005134	ENSSHAP00000003094	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.998
AP2A2	CLTC	ENSSHAP00000005134	ENSSHAP00000019576	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.957
AP2A2	CLTCL1	ENSSHAP00000005134	ENSSHAP00000010155	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.957
AP2A2	G3W0V5_SARHA	ENSSHAP00000005134	ENSSHAP00000009060	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.569
AP2A2	GRB2	ENSSHAP00000005134	ENSSHAP00000021710	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Growth factor receptor bound protein 2.	0.519