(46 nodes) p53-Independent DNA Damage Response network (Sarcophilus harrisii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMF1	Proteasome inhibitor subunit 1. (234 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSME4	Proteasome activator subunit 4. (1786 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (470 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (379 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	UBB	Ubiquitin B. (233 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
	PSMD9	PDZ domain-containing protein. (234 aa)
	PSMA2	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (233 aa)
	PSMA6	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (246 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (843 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (163 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (355 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (442 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3. (511 aa)
	PSMA7	Proteasome subunit alpha type. (251 aa)
	UBC	Uncharacterized protein. (303 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (374 aa)
	PSME2	Proteasome activator subunit 2. (253 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (378 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (231 aa)
	PSMA1	Proteasome subunit alpha type. (263 aa)
	PSMB1	Proteasome subunit beta. (244 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (445 aa)
	PSMA8	Proteasome subunit alpha type. (257 aa)
	PSMB2	Proteasome subunit beta. (173 aa)
	PSMD5	Proteasome 26S subunit, non-ATPase 5. (507 aa)
	PSMB3	Proteasome subunit beta. (205 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (414 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	G3VVU2_SARHA	AAA domain-containing protein; Belongs to the AAA ATPase family. (389 aa)
	KXD1	KxDL motif containing 1. (181 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	PSMB10	Proteasome subunit beta 10. (386 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (348 aa)
	CHEK2	Checkpoint kinase 2. (519 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHEK1	CHEK2	ENSSHAP00000020571	ENSSHAP00000011768	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Checkpoint kinase 2.	0.989
CHEK2	CHEK1	ENSSHAP00000011768	ENSSHAP00000020571	Checkpoint kinase 2.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.989
CHEK2	RPS27A	ENSSHAP00000011768	ENSSHAP00000005686	Checkpoint kinase 2.	Ubiquitin-like domain-containing protein.	0.472
G3VVU2_SARHA	PSMA1	ENSSHAP00000007297	ENSSHAP00000018410	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.997
G3VVU2_SARHA	PSMA2	ENSSHAP00000007297	ENSSHAP00000006393	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome endopeptidase complex; Belongs to the peptidase T1A family.	0.996
G3VVU2_SARHA	PSMA3	ENSSHAP00000007297	ENSSHAP00000021180	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.998
G3VVU2_SARHA	PSMA4	ENSSHAP00000007297	ENSSHAP00000020551	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.998
G3VVU2_SARHA	PSMA5	ENSSHAP00000007297	ENSSHAP00000021354	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.997
G3VVU2_SARHA	PSMA6	ENSSHAP00000007297	ENSSHAP00000006258	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome endopeptidase complex; Belongs to the peptidase T1A family.	0.996
G3VVU2_SARHA	PSMA7	ENSSHAP00000007297	ENSSHAP00000018240	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.955
G3VVU2_SARHA	PSMA8	ENSSHAP00000007297	ENSSHAP00000019973	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit alpha type.	0.955
G3VVU2_SARHA	PSMB1	ENSSHAP00000007297	ENSSHAP00000018549	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.993
G3VVU2_SARHA	PSMB10	ENSSHAP00000007297	ENSSHAP00000008923	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta 10.	0.938
G3VVU2_SARHA	PSMB2	ENSSHAP00000007297	ENSSHAP00000020034	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.996
G3VVU2_SARHA	PSMB3	ENSSHAP00000007297	ENSSHAP00000020459	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.995
G3VVU2_SARHA	PSMB4	ENSSHAP00000007297	ENSSHAP00000017318	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.997
G3VVU2_SARHA	PSMB5	ENSSHAP00000007297	ENSSHAP00000015899	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.994
G3VVU2_SARHA	PSMB6	ENSSHAP00000007297	ENSSHAP00000003074	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.994
G3VVU2_SARHA	PSMB7	ENSSHAP00000007297	ENSSHAP00000018917	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome subunit beta.	0.938
G3VVU2_SARHA	PSMC1	ENSSHAP00000007297	ENSSHAP00000019919	AAA domain-containing protein; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.999