6 items (Sarcophilus harrisii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRB2	Growth factor receptor bound protein 2. (191 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	GAB1	GRB2 associated binding protein 1. (694 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (761 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1379 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAB1	GRB2	ENSSHAP00000010582	ENSSHAP00000021710	GRB2 associated binding protein 1.	Growth factor receptor bound protein 2.	0.993
GAB1	HGF	ENSSHAP00000010582	ENSSHAP00000018582	GRB2 associated binding protein 1.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.680
GAB1	MET	ENSSHAP00000010582	ENSSHAP00000018708	GRB2 associated binding protein 1.	MET proto-oncogene, receptor tyrosine kinase.	0.982
GAB1	PIK3CA	ENSSHAP00000010582	ENSSHAP00000019318	GRB2 associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.545
GAB1	PIK3R1	ENSSHAP00000010582	ENSSHAP00000009338	GRB2 associated binding protein 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.854
GRB2	GAB1	ENSSHAP00000021710	ENSSHAP00000010582	Growth factor receptor bound protein 2.	GRB2 associated binding protein 1.	0.993
GRB2	HGF	ENSSHAP00000021710	ENSSHAP00000018582	Growth factor receptor bound protein 2.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.580
GRB2	MET	ENSSHAP00000021710	ENSSHAP00000018708	Growth factor receptor bound protein 2.	MET proto-oncogene, receptor tyrosine kinase.	0.992
GRB2	PIK3CA	ENSSHAP00000021710	ENSSHAP00000019318	Growth factor receptor bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.698
GRB2	PIK3R1	ENSSHAP00000021710	ENSSHAP00000009338	Growth factor receptor bound protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.959
HGF	GAB1	ENSSHAP00000018582	ENSSHAP00000010582	Hepatocyte growth factor; Belongs to the peptidase S1 family.	GRB2 associated binding protein 1.	0.680
HGF	GRB2	ENSSHAP00000018582	ENSSHAP00000021710	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Growth factor receptor bound protein 2.	0.580
HGF	MET	ENSSHAP00000018582	ENSSHAP00000018708	Hepatocyte growth factor; Belongs to the peptidase S1 family.	MET proto-oncogene, receptor tyrosine kinase.	0.998
HGF	PIK3CA	ENSSHAP00000018582	ENSSHAP00000019318	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.510
HGF	PIK3R1	ENSSHAP00000018582	ENSSHAP00000009338	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Phosphoinositide-3-kinase regulatory subunit 1.	0.416
MET	GAB1	ENSSHAP00000018708	ENSSHAP00000010582	MET proto-oncogene, receptor tyrosine kinase.	GRB2 associated binding protein 1.	0.982
MET	GRB2	ENSSHAP00000018708	ENSSHAP00000021710	MET proto-oncogene, receptor tyrosine kinase.	Growth factor receptor bound protein 2.	0.992
MET	HGF	ENSSHAP00000018708	ENSSHAP00000018582	MET proto-oncogene, receptor tyrosine kinase.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.998
MET	PIK3CA	ENSSHAP00000018708	ENSSHAP00000019318	MET proto-oncogene, receptor tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.967
MET	PIK3R1	ENSSHAP00000018708	ENSSHAP00000009338	MET proto-oncogene, receptor tyrosine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.888