(7 nodes) Phosphotyrosine-binding domain (IRS1-like) network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	DOK2	Docking protein 2. (423 aa)
	DOK1	Docking protein 1. (458 aa)
	IRS2	Insulin receptor substrate 2. (1163 aa)
	IRS1	Insulin receptor substrate 1. (1234 aa)
	DOK3	Docking protein 3. (463 aa)
	IRS4	IRS-type PTB domain-containing protein. (870 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FRS2	IRS1	ENSSHAP00000005629	ENSSHAP00000017218	Fibroblast growth factor receptor substrate 2.	Insulin receptor substrate 1.	0.404
FRS2	IRS2	ENSSHAP00000005629	ENSSHAP00000017632	Fibroblast growth factor receptor substrate 2.	Insulin receptor substrate 2.	0.404
FRS2	IRS4	ENSSHAP00000005629	ENSSHAP00000012985	Fibroblast growth factor receptor substrate 2.	IRS-type PTB domain-containing protein.	0.404
IRS1	FRS2	ENSSHAP00000017218	ENSSHAP00000005629	Insulin receptor substrate 1.	Fibroblast growth factor receptor substrate 2.	0.404
IRS1	IRS4	ENSSHAP00000017218	ENSSHAP00000012985	Insulin receptor substrate 1.	IRS-type PTB domain-containing protein.	0.900
IRS2	FRS2	ENSSHAP00000017632	ENSSHAP00000005629	Insulin receptor substrate 2.	Fibroblast growth factor receptor substrate 2.	0.404
IRS4	FRS2	ENSSHAP00000012985	ENSSHAP00000005629	IRS-type PTB domain-containing protein.	Fibroblast growth factor receptor substrate 2.	0.404
IRS4	IRS1	ENSSHAP00000012985	ENSSHAP00000017218	IRS-type PTB domain-containing protein.	Insulin receptor substrate 1.	0.900