(48 nodes) Valine, leucine and isoleucine degradation network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100914188	Uncharacterized protein. (139 aa)
	ACADSB	Acyl-CoA dehydrogenase short/branched chain. (433 aa)
	G3VDT8_SARHA	Amine oxidase. (534 aa)
	ACAA2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	MMUT	Methylmalonyl-CoA mutase. (750 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (338 aa)
	BCAT1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (398 aa)
	PCCB	Propionyl-CoA carboxylase subunit beta. (562 aa)
	G3VLP6_SARHA	Amine oxidase. (528 aa)
	DLD	Dihydrolipoyl dehydrogenase. (508 aa)
	G3VQB9_SARHA	Amino_oxidase domain-containing protein. (286 aa)
	MCCC2	Methylcrotonoyl-CoA carboxylase 2. (526 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (317 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (236 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (327 aa)
	G3VSK4_SARHA	Aldedh domain-containing protein. (186 aa)
	LOC100932442	Amine oxidase. (554 aa)
	AACS	Acetoacetyl-CoA synthetase. (631 aa)
	HSD17B10	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
	ACAA1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (345 aa)
	OXCT1	Uncharacterized protein. (328 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (326 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (506 aa)
	ECHS1	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (524 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (606 aa)
	LOC100929481	Uncharacterized protein. (1289 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
	ACSF3	Acyl-CoA synthetase family member 3. (584 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	ALDH7A1	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (540 aa)
	ACAD8	Acyl-CoA dehydrogenase family member 8. (415 aa)
	HADHA	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (765 aa)
	ALDH1B1	Aldehyde dehydrogenase 1 family member B1; Belongs to the aldehyde dehydrogenase family. (517 aa)
	HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (473 aa)
	HIBCH	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
	PCCA	Uncharacterized protein. (349 aa)
	HIBADH	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (300 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (509 aa)
	BCKDHB	Branched chain keto acid dehydrogenase E1 subunit beta. (322 aa)
	MCCC1	Methylcrotonoyl-CoA carboxylase 1. (698 aa)
	ALDH9A1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (463 aa)
	AOX1	Aldehyde oxidase 1. (1342 aa)
	MCEE	Methylmalonyl-CoA epimerase. (176 aa)
	G3WW70_SARHA	Uncharacterized protein. (1346 aa)
	G3WWT1_SARHA	Uncharacterized protein. (1336 aa)
	LOC100934782	CoA carboxyltransferase N-terminal domain-containing protein. (611 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (506 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAA1	ENSSHAP00000006439	ENSSHAP00000007735	Acetoacetyl-CoA synthetase.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.495
AACS	ACAA2	ENSSHAP00000006439	ENSSHAP00000001391	Acetoacetyl-CoA synthetase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.472
AACS	ACAT1	ENSSHAP00000006439	ENSSHAP00000013889	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.959
AACS	ACAT2	ENSSHAP00000006439	ENSSHAP00000002089	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.947
AACS	ACSF3	ENSSHAP00000006439	ENSSHAP00000015011	Acetoacetyl-CoA synthetase.	Acyl-CoA synthetase family member 3.	0.476
AACS	ALDH1B1	ENSSHAP00000006439	ENSSHAP00000016655	Acetoacetyl-CoA synthetase.	Aldehyde dehydrogenase 1 family member B1; Belongs to the aldehyde dehydrogenase family.	0.416
AACS	ALDH7A1	ENSSHAP00000006439	ENSSHAP00000015440	Acetoacetyl-CoA synthetase.	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family.	0.400
AACS	ALDH9A1	ENSSHAP00000006439	ENSSHAP00000019338	Acetoacetyl-CoA synthetase.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.416
AACS	ECHS1	ENSSHAP00000006439	ENSSHAP00000012626	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.437
AACS	EHHADH	ENSSHAP00000006439	ENSSHAP00000013720	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase.	0.938
AACS	G3VSK4_SARHA	ENSSHAP00000006439	ENSSHAP00000006159	Acetoacetyl-CoA synthetase.	Aldedh domain-containing protein.	0.416
AACS	HADH	ENSSHAP00000006439	ENSSHAP00000005708	Acetoacetyl-CoA synthetase.	Hydroxyacyl-CoA dehydrogenase.	0.945
AACS	HADHA	ENSSHAP00000006439	ENSSHAP00000016590	Acetoacetyl-CoA synthetase.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	0.413
AACS	HADHB	ENSSHAP00000006439	ENSSHAP00000016898	Acetoacetyl-CoA synthetase.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.525
AACS	HIBCH	ENSSHAP00000006439	ENSSHAP00000017216	Acetoacetyl-CoA synthetase.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.406
AACS	HMGCL	ENSSHAP00000006439	ENSSHAP00000006036	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.941
AACS	HMGCLL1	ENSSHAP00000006439	ENSSHAP00000005948	Acetoacetyl-CoA synthetase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.941
AACS	HMGCS1	ENSSHAP00000006439	ENSSHAP00000012708	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.945
AACS	HMGCS2	ENSSHAP00000006439	ENSSHAP00000018264	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.930
AACS	LOC100914188	ENSSHAP00000006439	ENSSHAP00000000354	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.406