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CALM1-2 CALM1-2 SLC25A4 SLC25A4 CNGA1 CNGA1 GUCY1B1 GUCY1B1 TRPC6 TRPC6 GUCY1A2 GUCY1A2 PIK3R5 PIK3R5 ADCY2 ADCY2 CALML4 CALML4 SLC8A1 SLC8A1 PPP3CA PPP3CA GNAI3 GNAI3 ATP2B4 ATP2B4 PPP3CB PPP3CB KNG1 KNG1 MRVI1 MRVI1 FXYD2 FXYD2 MYLK3 MYLK3 GUCY1A1 GUCY1A1 ATP1B1 ATP1B1 CALML3 CALML3 PPP1CA PPP1CA ADRA1A ADRA1A ATP2B3 ATP2B3 ADCY3 ADCY3 GNA11 GNA11 PPP3R1 PPP3R1 ITPR3 ITPR3 ADCY4 ADCY4 GNAI1 GNAI1 BDKRB2 BDKRB2 ADRA1B ADRA1B ADRA2B ADRA2B KCNMB4 KCNMB4 NFATC4 NFATC4 EDNRA EDNRA ADCY6 ADCY6 INSR INSR MAPK1 MAPK1 AGTR1 AGTR1 EDNRB EDNRB PIK3CG PIK3CG NPPB NPPB NPPA NPPA MYL9 MYL9 ADCY1 ADCY1 AKT1 AKT1 PPP1CB PPP1CB NFATC1 NFATC1 NOS3 NOS3 ATP1A2 ATP1A2 MAP2K2 MAP2K2 PDE2A PDE2A PDE5A PDE5A GNAQ GNAQ CREB3L3 CREB3L3 ATF6B ATF6B NFATC3 NFATC3 NPR1 NPR1 MEF2C MEF2C OPRD1 OPRD1 ATP1B4 ATP1B4 ADRA2A ADRA2A MAPK3 MAPK3 ATF2 ATF2 RAF1 RAF1 IRS4 IRS4 GNA13 GNA13 KCNU1 KCNU1 ADRA2C ADRA2C CREB3L2 CREB3L2 CREB3L4 CREB3L4 VDAC2 VDAC2 ADRB2 ADRB2 ATP2A1 ATP2A1 RGS2 RGS2 CREB5 CREB5 ADCY9 ADCY9 MEF2B MEF2B ITPR1 ITPR1 SRF SRF GNA12 GNA12 SLC25A31 SLC25A31 PLCB2 PLCB2 ADORA3 ADORA3 PPP1CC PPP1CC CREB1 CREB1 NPR2 NPR2 ATF4 ATF4 CREB3 CREB3 ROCK1 ROCK1 IRS1 IRS1 MEF2D MEF2D KCNJ8 KCNJ8 MYH7 MYH7 CACNA1C CACNA1C CREB3L1 CREB3L1 ATP1B2 ATP1B2 PLCB1 PLCB1 KCNMB2 KCNMB2 G3WT87_SARHA G3WT87_SARHA RHOA RHOA ADORA1 ADORA1 CACNA1D CACNA1D KCNMB3 KCNMB3 PRKG2 PRKG2 ADRB3 ADRB3 ATP1A1 ATP1A1 MEF2A MEF2A ATP1B3 ATP1B3 PDE3A PDE3A ATP2B2 ATP2B2 VDAC1 VDAC1 VDAC3 VDAC3 NFATC2 NFATC2 PPP3CC PPP3CC GNAI2 GNAI2 ADCY7 ADCY7 KCNMB1 KCNMB1 SLC8A3 SLC8A3 G3X3U5_SARHA G3X3U5_SARHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (690 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (770 aa)
GUCY1A2Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (396 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
CALML4Calmodulin like 4. (155 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (601 aa)
PPP3CASerine/threonine-protein phosphatase. (502 aa)
GNAI3G protein subunit alpha i3. (323 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
PPP3CBSerine/threonine-protein phosphatase. (501 aa)
KNG1Uncharacterized protein. (607 aa)
MRVI1Murine retrovirus integration site 1 homolog. (903 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (72 aa)
MYLK3Myosin light chain kinase 3. (810 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
ADRA1AAdrenoceptor alpha 1A. (465 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1253 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
GNA11G protein subunit alpha 11. (316 aa)
PPP3R1Uncharacterized protein. (170 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2665 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
GNAI1G protein subunit alpha i1. (354 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (389 aa)
ADRA1BAdrenoceptor alpha 1B. (505 aa)
ADRA2BAdrenoceptor alpha 2B. (438 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
NFATC4Nuclear factor of activated T cells 4. (875 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
INSRFibronectin type-III domain-containing protein. (535 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (433 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1103 aa)
NPPBUncharacterized protein. (135 aa)
NPPANatriuretic peptide A. (144 aa)
MYL9Myosin light chain 9. (172 aa)
ADCY1AC_N domain-containing protein. (214 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP1CBSerine/threonine-protein phosphatase. (268 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
NOS3Nitric oxide synthase 3. (1022 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
PDE2APhosphodiesterase. (835 aa)
PDE5APhosphodiesterase. (896 aa)
GNAQG protein subunit alpha q. (359 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
ATF6BActivating transcription factor 6 beta. (709 aa)
NFATC3Nuclear factor of activated T cells 3. (1052 aa)
NPR1Guanylate cyclase. (1013 aa)
MEF2CMyocyte enhancer factor 2C. (467 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (308 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (349 aa)
ADRA2AAdrenoceptor alpha 2A. (438 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
IRS4IRS-type PTB domain-containing protein. (870 aa)
GNA13G protein subunit alpha 13. (207 aa)
KCNU1Uncharacterized protein. (978 aa)
ADRA2CAdrenoceptor alpha 2C. (472 aa)
CREB3L2BZIP domain-containing protein. (517 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (389 aa)
VDAC2Voltage dependent anion channel 2. (293 aa)
ADRB2Adrenoceptor beta 2. (393 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
RGS2Regulator of G protein signaling 2. (213 aa)
CREB5Uncharacterized protein. (109 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
MEF2BMyocyte enhancer factor 2B. (317 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2696 aa)
SRFSerum response factor. (306 aa)
GNA12G protein subunit alpha 12. (233 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (241 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
ADORA3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (319 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
NPR2Guanylate cyclase. (1062 aa)
ATF4Activating transcription factor 4. (344 aa)
CREB3BZIP domain-containing protein. (370 aa)
ROCK1Uncharacterized protein. (516 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
MEF2DMyocyte enhancer factor 2D. (525 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PLCB1Phosphoinositide phospholipase C. (1041 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (270 aa)
G3WT87_SARHAGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (655 aa)
RHOAUncharacterized protein. (193 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (325 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (284 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ADRB3G_PROTEIN_RECEP_F1_2 domain-containing protein. (408 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (999 aa)
MEF2AMyocyte enhancer factor 2A. (498 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (326 aa)
PDE3APhosphodiesterase. (804 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1209 aa)
VDAC1Voltage dependent anion channel 1. (298 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
NFATC2Nuclear factor of activated T cells 2. (703 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
GNAI2G protein subunit alpha i2. (319 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
G3X3U5_SARHACalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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