STRINGSTRING
PIK3CB PIK3CB CALM1-2 CALM1-2 GIPR GIPR CNGA1 CNGA1 CAMK2D CAMK2D MAPK10 MAPK10 PDE4B PDE4B ADORA2A ADORA2A GRIA2 GRIA2 SUCNR1 SUCNR1 ADCY2 ADCY2 CALML4 CALML4 PPARA PPARA PLD2 PLD2 NFKBIA NFKBIA HTR1A HTR1A CNGA4 CNGA4 GNAI3 GNAI3 SSTR1 SSTR1 ATP2B4 ATP2B4 HTR1B HTR1B FXYD2 FXYD2 GABBR1 GABBR1 TSHR TSHR VAV1 VAV1 LOC100929360 LOC100929360 HTR1E HTR1E NPY1R NPY1R RAPGEF3 RAPGEF3 ATP1B1 ATP1B1 CALML3 CALML3 PPP1CA PPP1CA MAPK9 MAPK9 EDN2 EDN2 ATP2B3 ATP2B3 HTR1F HTR1F ADCY3 ADCY3 PAK1 PAK1 ADCY4 ADCY4 GNAI1 GNAI1 PDE4A PDE4A GLI1 GLI1 EP300 EP300 RAPGEF4 RAPGEF4 CHRM2 CHRM2 EDNRA EDNRA CGA CGA ADCY6 ADCY6 NFKB1 NFKB1 ADCYAP1 ADCYAP1 DRD5 DRD5 TIAM1 TIAM1 MAPK1 MAPK1 PIK3R1 PIK3R1 GRIN2A GRIN2A GHSR GHSR NPPA NPPA MYL9 MYL9 ADCY1 ADCY1 AKT1 AKT1 PPP1CB PPP1CB NFATC1 NFATC1 F2R F2R NPY NPY ATP1A2 ATP1A2 PRKACA PRKACA MAP2K2 MAP2K2 HCN2 HCN2 RYR2 RYR2 GRIN1 GRIN1 GLI3 GLI3 PIK3R2 PIK3R2 CREB3L3 CREB3L3 GRIN3A GRIN3A NPR1 NPR1 ATP1B4 ATP1B4 VAV2 VAV2 CNGA3 CNGA3 MAPK3 MAPK3 RAF1 RAF1 HTR1D HTR1D ARAP3 ARAP3 EDN3 EDN3 GRIN2B GRIN2B OXTR OXTR TSHB TSHB RAP1B RAP1B CREB3L2 CREB3L2 LOC100930415 LOC100930415 CREB3L4 CREB3L4 HCAR1 HCAR1 HHIP HHIP CNGA2 CNGA2 ADRB2 ADRB2 GABBR2 GABBR2 ATP2A1 ATP2A1 CREB5 CREB5 FSHR FSHR ADCY9 ADCY9 PPP1CC PPP1CC GNAS GNAS HTR4 HTR4 GRIA4 GRIA4 CREBBP CREBBP CREB1 CREB1 VAV3 VAV3 RAP1A RAP1A GIP GIP SST SST CREB3 CREB3 ROCK1 ROCK1 VIPR2 VIPR2 BDNF BDNF PTCH1 PTCH1 LHCGR LHCGR DRD2 DRD2 RAC2 RAC2 GRIA3 GRIA3 CAMK2B CAMK2B EDN1 EDN1 PLCE1 PLCE1 CACNA1C CACNA1C LOC100913731 LOC100913731 CREB3L1 CREB3L1 ATP1B2 ATP1B2 MC2R MC2R RRAS2 RRAS2 SSTR2 SSTR2 ACOX3 ACOX3 GPR119 GPR119 RHOA RHOA PIK3CA PIK3CA ADORA1 ADORA1 CACNA1D CACNA1D PDE4D PDE4D ATP1A1 ATP1A1 ATP1B3 ATP1B3 PDE3A PDE3A ATP2B2 ATP2B2 CAMK2A CAMK2A ACOX1 ACOX1 MAPK8 MAPK8 GCG GCG FOS FOS SSTR5 SSTR5 SOX9 SOX9 GNAI2 GNAI2 ADCY7 ADCY7 ADCY10 ADCY10 G3X3U5_SARHA G3X3U5_SARHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (447 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (690 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PDE4BPhosphodiesterase. (491 aa)
ADORA2AG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (111 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (852 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (310 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
CALML4Calmodulin like 4. (155 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
PLD2Phospholipase. (934 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
HTR1A5-hydroxytryptamine receptor 1A. (416 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (541 aa)
GNAI3G protein subunit alpha i3. (323 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
HTR1B5-hydroxytryptamine receptor 1B. (389 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (72 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (964 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (705 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
EDN2Uncharacterized protein. (177 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1253 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PDE4APhosphodiesterase. (683 aa)
GLI1GLI family zinc finger 1. (1097 aa)
EP300E1A binding protein p300. (1895 aa)
RAPGEF4Uncharacterized protein. (678 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (467 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (174 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (426 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1594 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1333 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
NPPANatriuretic peptide A. (144 aa)
MYL9Myosin light chain 9. (172 aa)
ADCY1AC_N domain-containing protein. (214 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP1CBSerine/threonine-protein phosphatase. (268 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
NPYNeuropeptide Y. (97 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (524 aa)
RYR2Uncharacterized protein. (3999 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (933 aa)
GLI3GLI family zinc finger 3. (1583 aa)
PIK3R2Uncharacterized protein. (738 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
GRIN3AUncharacterized protein. (1055 aa)
NPR1Guanylate cyclase. (1013 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (349 aa)
VAV2Vav guanine nucleotide exchange factor 2. (699 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (709 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
HTR1DG_PROTEIN_RECEP_F1_2 domain-containing protein. (377 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1556 aa)
EDN3Uncharacterized protein. (201 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1118 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (387 aa)
TSHBThyroid stimulating hormone subunit beta. (138 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
CREB3L2BZIP domain-containing protein. (517 aa)
LOC100930415G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (389 aa)
HCAR1Hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (342 aa)
HHIPHedgehog interacting protein. (701 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (665 aa)
ADRB2Adrenoceptor beta 2. (393 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (813 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
CREB5Uncharacterized protein. (109 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
GNASUncharacterized protein. (320 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
GRIA4ANF_receptor domain-containing protein. (433 aa)
CREBBPCREB binding protein. (2452 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
VAV3Vav guanine nucleotide exchange factor 3. (846 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GIPGLUCAGON domain-containing protein. (78 aa)
SSTSomatostatin. (116 aa)
CREB3BZIP domain-containing protein. (370 aa)
ROCK1Uncharacterized protein. (516 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (319 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (246 aa)
PTCH1Patched 1. (1433 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (698 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (454 aa)
RAC2Rac family small GTPase 2. (192 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (892 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
EDN1Endothelin 1. (214 aa)
PLCE1Phosphoinositide phospholipase C. (1808 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
MC2RMelanocortin 2 receptor. (304 aa)
RRAS2RAS related 2. (175 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (701 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (307 aa)
RHOAUncharacterized protein. (193 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (325 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
PDE4DPhosphodiesterase. (768 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (999 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (326 aa)
PDE3APhosphodiesterase. (804 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1209 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (645 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
GCGGlucagon. (180 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (369 aa)
SOX9SRY-box transcription factor 9. (552 aa)
GNAI2G protein subunit alpha i2. (319 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
ADCY10Adenylate cyclase 10. (1609 aa)
G3X3U5_SARHACalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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