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CHUK CHUK PXN PXN PIK3CB PIK3CB ARRB2 ARRB2 G3VAQ8_SARHA G3VAQ8_SARHA LOC100915784 LOC100915784 STAT2 STAT2 G3VBX3_SARHA G3VBX3_SARHA CRKL CRKL FGR FGR CCR4 CCR4 SHC3 SHC3 LOC100916737 LOC100916737 PTK2B PTK2B GNG8 GNG8 LOC100925102 LOC100925102 LOC100917003 LOC100917003 PIK3R5 PIK3R5 GNG12 GNG12 G3VHR9_SARHA G3VHR9_SARHA ADCY2 ADCY2 LOC100922240 LOC100922240 LOC100917781 LOC100917781 NFKBIA NFKBIA GNAI3 GNAI3 SOS2 SOS2 LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA CX3CR1 CX3CR1 G3VMD1_SARHA G3VMD1_SARHA STAT5B STAT5B CXCL9 CXCL9 GNGT1 GNGT1 LOC100920799 LOC100920799 SHC1 SHC1 VAV1 VAV1 LOC100929360 LOC100929360 JAK3 JAK3 CXCL14 CXCL14 CCR8 CCR8 ADCY3 ADCY3 PAK1 PAK1 ADCY4 ADCY4 GNAI1 GNAI1 PARD3 PARD3 RASGRP2 RASGRP2 ADCY6 ADCY6 NFKB1 NFKB1 PRKCZ PRKCZ CXCL13 CXCL13 TIAM1 TIAM1 MAPK1 MAPK1 PIK3R1 PIK3R1 CXCR4 CXCR4 PRKCD PRKCD PIK3CG PIK3CG PRKCB PRKCB GNB2 GNB2 ADCY1 ADCY1 AKT1 AKT1 CXCR3 CXCR3 CCL20 CCL20 PRKACA PRKACA GNAQ GNAQ PIK3R2 PIK3R2 XCR1 XCR1 GRK4 GRK4 CCL28 CCL28 CCR7 CCR7 VAV2 VAV2 CCR3 CCR3 MAPK3 MAPK3 PTK2 PTK2 RAF1 RAF1 LOC100913351 LOC100913351 LOC100913616 LOC100913616 SHC2 SHC2 RAP1B RAP1B PLCG2 PLCG2 LYN LYN HCK HCK PREX1 PREX1 ARRB1 ARRB1 GNB1 GNB1 ADCY9 ADCY9 CCR6 CCR6 PLCB2 PLCB2 GRK5 GRK5 LOC111720800 LOC111720800 CCR10 CCR10 G3WKU6_SARHA G3WKU6_SARHA GNG13 GNG13 LOC105750536 LOC105750536 G3WLZ4_SARHA G3WLZ4_SARHA VAV3 VAV3 RAP1A RAP1A G3WND9_SARHA G3WND9_SARHA ROCK1 ROCK1 GRK6 GRK6 SOS1 SOS1 STAT3 STAT3 RAC2 RAC2 JAK2 JAK2 CCL22 CCL22 GRK1 GRK1 CX3CL1 CX3CL1 CCL17 CCL17 LOC100913731 LOC100913731 SHC4 SHC4 PLCB1 PLCB1 ITK ITK CXCL8 CXCL8 GNB3 GNB3 G3WUN3_SARHA G3WUN3_SARHA RHOA RHOA PIK3CA PIK3CA G3WWF6_SARHA G3WWF6_SARHA LOC100922206 LOC100922206 STAT1 STAT1 GNB4 GNB4 CCL21 CCL21 GRK7 GRK7 CCL19 CCL19 GNB5 GNB5 CCL27 CCL27 SRC SRC GNG5 GNG5 IKBKB IKBKB DOCK2 DOCK2 FOXO3 FOXO3 GRB2 GRB2 GNAI2 GNAI2 ADCY7 ADCY7 LOC100914986 LOC100914986
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (295 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
ARRB2Arrestin beta 2. (409 aa)
G3VAQ8_SARHAG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
LOC100915784SCY domain-containing protein. (91 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
G3VBX3_SARHASCY domain-containing protein. (94 aa)
CRKLCRK like proto-oncogene, adaptor protein. (194 aa)
FGRTyrosine-protein kinase. (531 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SHC3SHC adaptor protein 3. (422 aa)
LOC100916737C-C motif chemokine. (91 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1012 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC100925102C-C motif chemokine. (91 aa)
LOC100917003C-C motif chemokine. (91 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
G3VHR9_SARHAC-C motif chemokine. (91 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
LOC100922240SCY domain-containing protein. (105 aa)
LOC100917781SCY domain-containing protein. (109 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
GNAI3G protein subunit alpha i3. (323 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1329 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
G3VMD1_SARHAC-C motif chemokine. (90 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CXCL9SCY domain-containing protein. (128 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LOC100920799Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
SHC1SHC adaptor protein 1. (569 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
JAK3Tyrosine-protein kinase. (1110 aa)
CXCL14C-X-C motif chemokine ligand 14. (100 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PARD3Uncharacterized protein. (651 aa)
RASGRP2RAS guanyl releasing protein 2. (444 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (453 aa)
CXCL13SCY domain-containing protein. (104 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1594 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (347 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1103 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
GNB2G protein subunit beta 2. (340 aa)
ADCY1AC_N domain-containing protein. (214 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (365 aa)
CCL20SCY domain-containing protein. (115 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
GNAQG protein subunit alpha q. (359 aa)
PIK3R2Uncharacterized protein. (738 aa)
XCR1X-C motif chemokine receptor 1. (336 aa)
GRK4G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (530 aa)
CCL28C-C motif chemokine. (110 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
VAV2Vav guanine nucleotide exchange factor 2. (699 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
LOC100913351G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
LOC100913616G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (349 aa)
SHC2Uncharacterized protein. (479 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
LYNTyrosine-protein kinase. (514 aa)
HCKTyrosine-protein kinase. (541 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1505 aa)
ARRB1Arrestin beta 1. (418 aa)
GNB1G protein subunit beta 1. (340 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (372 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (484 aa)
LOC111720800C-C motif chemokine. (98 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (361 aa)
G3WKU6_SARHAC-C motif chemokine. (143 aa)
GNG13G protein subunit gamma 13. (67 aa)
LOC105750536C-C motif chemokine. (100 aa)
G3WLZ4_SARHAC-C motif chemokine. (117 aa)
VAV3Vav guanine nucleotide exchange factor 3. (846 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
G3WND9_SARHASCY domain-containing protein. (64 aa)
ROCK1Uncharacterized protein. (516 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (544 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
RAC2Rac family small GTPase 2. (192 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
CCL22Uncharacterized protein. (65 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (565 aa)
CX3CL1SCY domain-containing protein. (417 aa)
CCL17SCY domain-containing protein. (136 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
SHC4SHC adaptor protein 4. (538 aa)
PLCB1Phosphoinositide phospholipase C. (1041 aa)
ITKTyrosine-protein kinase. (620 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
GNB3G protein subunit beta 3. (340 aa)
G3WUN3_SARHAC-X-C motif chemokine. (117 aa)
RHOAUncharacterized protein. (193 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
G3WWF6_SARHAG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LOC100922206G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
STAT1Signal transducer and activator of transcription. (762 aa)
GNB4G protein subunit beta 4. (340 aa)
CCL21C-C motif chemokine ligand 21. (139 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (548 aa)
CCL19C-C motif chemokine. (98 aa)
GNB5G protein subunit beta 5. (395 aa)
CCL27SCY domain-containing protein. (108 aa)
SRCTyrosine-protein kinase. (533 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1829 aa)
FOXO3Fork-head domain-containing protein. (487 aa)
GRB2Growth factor receptor bound protein 2. (191 aa)
GNAI2G protein subunit alpha i2. (319 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
LOC100914986SCY domain-containing protein. (117 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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