STRINGSTRING
PIK3CB PIK3CB IFNGR1 IFNGR1 LOC100921027 LOC100921027 EGF EGF ANGPT2 ANGPT2 PGK1 PGK1 CAMK2D CAMK2D LOC100921951 LOC100921951 PFKM PFKM RPS6KB2 RPS6KB2 LOC100925341 LOC100925341 MKNK1 MKNK1 HK1 HK1 RBX1 RBX1 PFKL PFKL SERPINE1 SERPINE1 G3VST0_SARHA G3VST0_SARHA RPS6 RPS6 LOC100924827 LOC100924827 ENO3 ENO3 G3VUU1_SARHA G3VUU1_SARHA EP300 EP300 NFKB1 NFKB1 INSR INSR EGLN1 EGLN1 MAPK1 MAPK1 EIF4E1B EIF4E1B PIK3R1 PIK3R1 MKNK2 MKNK2 IGF1 IGF1 EPO EPO EIF4E EIF4E CYBB CYBB PDHB PDHB PRKCB PRKCB NPPA NPPA NOS2 NOS2 AKT1 AKT1 NOS3 NOS3 MAP2K2 MAP2K2 PRKCA PRKCA PIK3R2 PIK3R2 LOC100925190 LOC100925190 ELOC ELOC HK2 HK2 ANGPT4 ANGPT4 HK3 HK3 ALDOA ALDOA MAPK3 MAPK3 PFKP PFKP IL6 IL6 CDKN1B CDKN1B CDKN1A CDKN1A PLCG2 PLCG2 ALDOB ALDOB HIF1A HIF1A ARNT ARNT EGLN3 EGLN3 EIF4E2 EIF4E2 IGF1R IGF1R CREBBP CREBBP ALDOC ALDOC LTBR LTBR STAT3 STAT3 GAPDH GAPDH IFNG IFNG CAMK2B CAMK2B ERBB2 ERBB2 SLC2A1 SLC2A1 EDN1 EDN1 PDHA1 PDHA1 LDHB LDHB LDHA LDHA RPS6KB1 RPS6KB1 VHL VHL ENO2 ENO2 PIK3CA PIK3CA LOC105749478 LOC105749478 TLR4 TLR4 ENO4 ENO4 CAMK2A CAMK2A CUL2 CUL2 PDK1 PDK1 ELOB ELOB BCL2 BCL2 FLT1 FLT1 HMOX1 HMOX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
IFNGR1Uncharacterized protein. (189 aa)
LOC100921027Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1183 aa)
EGFEpidermal growth factor. (1129 aa)
ANGPT2Uncharacterized protein. (96 aa)
PGK1Phosphoglycerate kinase. (399 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
LOC100921951Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (785 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (473 aa)
LOC100925341Uncharacterized protein. (458 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
HK1Hexokinase 1. (922 aa)
RBX1Ring-box 1. (108 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (788 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (400 aa)
G3VST0_SARHAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
LOC100924827Uncharacterized protein. (434 aa)
ENO3Enolase 3. (434 aa)
G3VUU1_SARHAUncharacterized protein. (431 aa)
EP300E1A binding protein p300. (1895 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
INSRFibronectin type-III domain-containing protein. (535 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (249 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (200 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MKNK2MAPK interacting serine/threonine kinase 2. (369 aa)
IGF1Insulin like growth factor 1. (130 aa)
EPOErythropoietin. (191 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
CYBBCytochrome b-245 beta chain. (471 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (271 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
NPPANatriuretic peptide A. (144 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NOS3Nitric oxide synthase 3. (1022 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
PIK3R2Uncharacterized protein. (738 aa)
LOC100925190Phosphoglycerate kinase. (418 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
HK2Hexokinase 2. (917 aa)
ANGPT4Angiopoietin 4. (499 aa)
HK3Hexokinase 3. (803 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (711 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (799 aa)
IL6Uncharacterized protein. (212 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (199 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (365 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (240 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
IGF1RTyrosine-protein kinase receptor. (1061 aa)
CREBBPCREB binding protein. (2452 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (365 aa)
LTBRLymphotoxin beta receptor. (419 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
EDN1Endothelin 1. (214 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (395 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (302 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (363 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (527 aa)
VHLUncharacterized protein. (100 aa)
ENO2Enolase 2. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
LOC105749478Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (237 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (828 aa)
ENO4Enolase 4. (602 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
CUL2Cullin 2; Belongs to the cullin family. (748 aa)
PDK1Protein-serine/threonine kinase. (371 aa)
ELOBElongin B. (118 aa)
BCL2BCL2 apoptosis regulator. (227 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (283 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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