STRINGSTRING
PIK3CB PIK3CB SMCR8 SMCR8 UVRAG UVRAG MAPK10 MAPK10 RPS6KB2 RPS6KB2 ATG3 ATG3 GABARAPL2 GABARAPL2 C9orf72 C9orf72 ULK2 ULK2 RAB1A RAB1A PTEN PTEN LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA RAB39B RAB39B ATG4B ATG4B ATG12 ATG12 RHEB RHEB ATG16L1 ATG16L1 NRBF2 NRBF2 LOC100929360 LOC100929360 TSC1 TSC1 ATG4D ATG4D MAPK9 MAPK9 ATG16L2 ATG16L2 TBK1 TBK1 MTMR3 MTMR3 RAB8A RAB8A EIF2AK3 EIF2AK3 DAPK1 DAPK1 IGBP1 IGBP1 STK11 STK11 WIPI2 WIPI2 GABARAPL1 GABARAPL1 MAPK1 MAPK1 PDPK1 PDPK1 PIK3R1 PIK3R1 G3W1X3_SARHA G3W1X3_SARHA GABARAP GABARAP G3W2P3_SARHA G3W2P3_SARHA PIK3R4 PIK3R4 PRKCD PRKCD ATG10 ATG10 LOC100915932 LOC100915932 RPTOR RPTOR RB1CC1 RB1CC1 LOC100933802 LOC100933802 PRKAA2 PRKAA2 ATG14 ATG14 AKT1 AKT1 MRAS MRAS WIPI1 WIPI1 PRKACA PRKACA MAP2K2 MAP2K2 ATG9B ATG9B CTSB CTSB PIK3R2 PIK3R2 EIF2S1 EIF2S1 MTMR4 MTMR4 SQSTM1 SQSTM1 EIF2AK4 EIF2AK4 MAPK3 MAPK3 LAMP2 LAMP2 ATG5 ATG5 RAF1 RAF1 IRS4 IRS4 HIF1A HIF1A STX17 STX17 ITPR1 ITPR1 ATG101 ATG101 BECN1 BECN1 ATG4A ATG4A ZFYVE1 ZFYVE1 ULK1 ULK1 ATG9A ATG9A BCL2L1 BCL2L1 IGF1R IGF1R CFLAR CFLAR TRAF6 TRAF6 HMGB1 HMGB1 ERN1 ERN1 PRKCQ PRKCQ PRKAA1 PRKAA1 RRAGD RRAGD IRS1 IRS1 MTMR14 MTMR14 LOC100913731 LOC100913731 AMBRA1 AMBRA1 TANK TANK TSC2 TSC2 RRAS2 RRAS2 RPS6KB1 RPS6KB1 ATG13 ATG13 CAMKK2 CAMKK2 G3WUW9_SARHA G3WUW9_SARHA PIK3CA PIK3CA PPP2CA PPP2CA LAMP1 LAMP1 RAB7B RAB7B RAB7A RAB7A MLST8 MLST8 RRAGC RRAGC MAPK8 MAPK8 MAP3K7 MAP3K7 TP53INP2 TP53INP2 BCL2 BCL2 G3X039_SARHA G3X039_SARHA DEPTOR DEPTOR ATG4C ATG4C WDR41 WDR41 DAPK2 DAPK2 ATG7 ATG7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
SMCR8SMCR8-C9orf72 complex subunit. (934 aa)
UVRAGUncharacterized protein. (179 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (473 aa)
ATG3Autophagy-related protein 3. (313 aa)
GABARAPL2GABA type A receptor associated protein like 2. (119 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1010 aa)
RAB1ARAB1A, member RAS oncogene family. (221 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
RAB39BRAB39B, member RAS oncogene family. (144 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (401 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (142 aa)
RHEBRas homolog, mTORC1 binding. (191 aa)
ATG16L1Autophagy related 16 like 1. (577 aa)
NRBF2Nuclear receptor binding factor 2. (280 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
TSC1TSC complex subunit 1. (1017 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (438 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
ATG16L2Autophagy related 16 like 2. (618 aa)
TBK1TANK binding kinase 1. (732 aa)
MTMR3Myotubularin related protein 3. (1180 aa)
RAB8ARAB8A, member RAS oncogene family. (208 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1081 aa)
DAPK1Uncharacterized protein. (737 aa)
IGBP1Uncharacterized protein. (351 aa)
STK11Serine/threonine kinase 11. (252 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (411 aa)
GABARAPL1Uncharacterized protein. (136 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PDPK1Protein kinase domain-containing protein. (558 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
G3W1X3_SARHAUncharacterized protein. (369 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
G3W2P3_SARHAPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (150 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1363 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
ATG10Autophagy related 10. (226 aa)
LOC100915932Uncharacterized protein. (220 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1056 aa)
RB1CC1RB1 inducible coiled-coil 1. (1592 aa)
LOC100933802Uncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
ATG14Autophagy related 14. (511 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (458 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (946 aa)
CTSBPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (342 aa)
PIK3R2Uncharacterized protein. (738 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
MTMR4Myotubularin related protein 4. (1200 aa)
SQSTM1Sequestosome 1. (401 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1598 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
LAMP2Lysosomal associated membrane protein 2. (416 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
IRS4IRS-type PTB domain-containing protein. (870 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
STX17Syntaxin 17. (301 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2696 aa)
ATG101Autophagy related 101. (218 aa)
BECN1Beclin 1. (448 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (265 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (785 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1063 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (842 aa)
BCL2L1BCL2 like 1. (227 aa)
IGF1RTyrosine-protein kinase receptor. (1061 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (496 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
HMGB1High mobility group box 1. (216 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (922 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
RRAGDRas related GTP binding D. (400 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
MTMR14Myotubularin related protein 14. (598 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1290 aa)
TANKTRAF family member associated NFKB activator. (446 aa)
TSC2TSC complex subunit 2. (1830 aa)
RRAS2RAS related 2. (175 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (527 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2; Belongs to the protein kinase superfamily. (443 aa)
G3WUW9_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (371 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PPP2CASerine/threonine-protein phosphatase. (333 aa)
LAMP1Lysosomal associated membrane protein 1. (405 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
RRAGCRas related GTP binding C. (328 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (214 aa)
BCL2BCL2 apoptosis regulator. (227 aa)
G3X039_SARHASerine/threonine-protein phosphatase. (322 aa)
DEPTORDEP domain containing MTOR interacting protein. (380 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
WDR41WD repeat domain 41. (459 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (365 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (708 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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