STRINGSTRING
LOC111720510 LOC111720510 IFNGR1 IFNGR1 STAT2 STAT2 GLUL GLUL CASP8 CASP8 SLC25A4 SLC25A4 IFNAR1 IFNAR1 G3VDA6_SARHA G3VDA6_SARHA LOC100920968 LOC100920968 FADD FADD PYGL PYGL RNF31 RNF31 EIF2AK2 EIF2AK2 TMED7-TICAM2 TMED7-TICAM2 CAMK2D CAMK2D G3VG54_SARHA G3VG54_SARHA PARP1 PARP1 MAPK10 MAPK10 PLA2G4D PLA2G4D PYDC1 PYDC1 LOC100924763 LOC100924763 LOC100914215 LOC100914215 CYLD CYLD FAS FAS PLA2G4E PLA2G4E FTL FTL PYCARD PYCARD LOC100929420 LOC100929420 STAT5B STAT5B TNF TNF PLA2G4F PLA2G4F H2AC1 H2AC1 CHMP1A CHMP1A CHMP2A CHMP2A JAK3 JAK3 CHMP7 CHMP7 SPATA2L SPATA2L RBCK1 RBCK1 G3VSY4_SARHA G3VSY4_SARHA MAPK9 MAPK9 G3VUC4_SARHA G3VUC4_SARHA G3VUU5_SARHA G3VUU5_SARHA SMPD1 SMPD1 LOC100924731 LOC100924731 G3VUY6_SARHA G3VUY6_SARHA G3VVW9_SARHA G3VVW9_SARHA STAT6 STAT6 TRAF2 TRAF2 TYK2 TYK2 MACROH2A2 MACROH2A2 CHMP6 CHMP6 HSP90AA1 HSP90AA1 IL1A IL1A CYBB CYBB TICAM1 TICAM1 CHMP2B CHMP2B IL1B IL1B BID BID GLUD1 GLUD1 H2AX H2AX SQSTM1 SQSTM1 PGAM5 PGAM5 TNFAIP3 TNFAIP3 CHMP4C CHMP4C FAF1 FAF1 SPATA2 SPATA2 G3WEC2_SARHA G3WEC2_SARHA VDAC2 VDAC2 TRPM7 TRPM7 CHMP3 CHMP3 SLC25A31 SLC25A31 VPS4A VPS4A CFLAR CFLAR HMGB1 HMGB1 TRAF5 TRAF5 JAK1 JAK1 RIPK1 RIPK1 STAT3 STAT3 JAK2 JAK2 IFNG IFNG CAMK2B CAMK2B AIFM1 AIFM1 XIAP XIAP CHMP4B CHMP4B USP21 USP21 PLA2G4A PLA2G4A G3WWR9_SARHA G3WWR9_SARHA G3WWW3_SARHA G3WWW3_SARHA STAT1 STAT1 H2AZ2 H2AZ2 TLR4 TLR4 CAMK2A CAMK2A HSP90AB1 HSP90AB1 VDAC1 VDAC1 MAPK8 MAPK8 PYGB PYGB LOC100914443 LOC100914443 LOC100914703 LOC100914703 LOC100914965 LOC100914965 BCL2 BCL2 VPS4B VPS4B VDAC3 VDAC3 FASLG FASLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111720510STAT_bind domain-containing protein. (112 aa)
IFNGR1Uncharacterized protein. (189 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
GLULUncharacterized protein. (79 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
IFNAR1Uncharacterized protein. (570 aa)
G3VDA6_SARHAUncharacterized protein. (73 aa)
LOC100920968Uncharacterized protein. (186 aa)
FADDUncharacterized protein. (193 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (626 aa)
RNF31Uncharacterized protein. (1072 aa)
EIF2AK2Uncharacterized protein. (563 aa)
TMED7-TICAM2TMED7-TICAM2 readthrough; Belongs to the EMP24/GP25L family. (379 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
G3VG54_SARHAHistone H2A; Belongs to the histone H2A family. (137 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PLA2G4DPhospholipase A2. (790 aa)
PYDC1Pyrin domain containing 1. (89 aa)
LOC100924763Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC100914215Histone H2A; Belongs to the histone H2A family. (130 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (936 aa)
FASUncharacterized protein. (283 aa)
PLA2G4EPhospholipase A2. (819 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (146 aa)
PYCARDUncharacterized protein. (200 aa)
LOC100929420Histone H2A; Belongs to the histone H2A family. (130 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
PLA2G4FPhospholipase A2. (845 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (132 aa)
CHMP1ACharged multivesicular body protein 1A. (197 aa)
CHMP2ACharged multivesicular body protein 2A. (221 aa)
JAK3Tyrosine-protein kinase. (1110 aa)
CHMP7Charged multivesicular body protein 7. (450 aa)
SPATA2LSpermatogenesis associated 2 like. (459 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (516 aa)
G3VSY4_SARHAHistone H2A; Belongs to the histone H2A family. (137 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
G3VUC4_SARHAHistone H2A; Belongs to the histone H2A family. (108 aa)
G3VUU5_SARHAUncharacterized protein. (420 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
LOC100924731Histone H2A; Belongs to the histone H2A family. (143 aa)
G3VUY6_SARHAHistone H2A; Belongs to the histone H2A family. (142 aa)
G3VVW9_SARHAHistone H2A; Belongs to the histone H2A family. (131 aa)
STAT6Signal transducer and activator of transcription. (853 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
TYK2Tyrosine-protein kinase. (1197 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
CHMP6Charged multivesicular body protein 6. (180 aa)
HSP90AA1HATPase_c domain-containing protein. (731 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (261 aa)
CYBBCytochrome b-245 beta chain. (471 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (690 aa)
CHMP2BCharged multivesicular body protein 2B. (212 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
GLUD1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (512 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (145 aa)
SQSTM1Sequestosome 1. (401 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (226 aa)
TNFAIP3TNF alpha induced protein 3. (792 aa)
CHMP4CCharged multivesicular body protein 4C. (232 aa)
FAF1Fas associated factor 1. (550 aa)
SPATA2Spermatogenesis associated 2. (528 aa)
G3WEC2_SARHAUncharacterized protein. (616 aa)
VDAC2Voltage dependent anion channel 2. (293 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1863 aa)
CHMP3Uncharacterized protein. (223 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (241 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (459 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (496 aa)
HMGB1High mobility group box 1. (216 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (579 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (716 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (580 aa)
XIAPX-linked inhibitor of apoptosis. (492 aa)
CHMP4BCharged multivesicular body protein 4B. (161 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (535 aa)
PLA2G4APhospholipase A2. (755 aa)
G3WWR9_SARHAHistone H2A; Belongs to the histone H2A family. (130 aa)
G3WWW3_SARHAUncharacterized protein. (200 aa)
STAT1Signal transducer and activator of transcription. (762 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (828 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
VDAC1Voltage dependent anion channel 1. (298 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (763 aa)
LOC100914443Uncharacterized protein. (187 aa)
LOC100914703Uncharacterized protein. (192 aa)
LOC100914965Uncharacterized protein. (183 aa)
BCL2BCL2 apoptosis regulator. (227 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (270 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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