(52 nodes) Cardiac muscle contraction network (Sarcophilus harrisii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	ASPH	Aspartate beta-hydroxylase. (710 aa)
	G3VDR7_SARHA	Uncharacterized protein. (453 aa)
	G3VHY9_SARHA	Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (72 aa)
	SLC8A1	J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (601 aa)
	SLC9A6	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (651 aa)
	FXYD2	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (72 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
	COX4I1	Cytochrome c oxidase subunit 4I1. (178 aa)
	TPM4	Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
	CYC1	Cytochrome c1. (285 aa)
	MYL3	Myosin light chain 3. (195 aa)
	G3VWL7_SARHA	COX6C domain-containing protein. (76 aa)
	CACNG6	Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (256 aa)
	COX6B1	Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
	TNNC1	Troponin C1, slow skeletal and cardiac type. (169 aa)
	RYR2	Uncharacterized protein. (3999 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (349 aa)
	G3WCX7_SARHA	Uncharacterized protein. (110 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
	CACNA2D4	Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1084 aa)
	UQCRC1	Ubiquinol-cytochrome c reductase core protein 1. (480 aa)
	CACNG3	Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (253 aa)
	COX7A2L	Cytochrome c oxidase subunit 7A2 like. (132 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
	CACNG1	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
	CACNA2D1	Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1085 aa)
	MYL2	Myosin light chain 2. (171 aa)
	TPM3	Tropomyosin 3; Belongs to the tropomyosin family. (284 aa)
	UQCRQ	Ubiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
	COX4I2	Cytochrome c oxidase subunit 4I2. (179 aa)
	COX6A2	Cytochrome c oxidase subunit 6A, mitochondrial. (97 aa)
	TPM2	Tropomyosin 2; Belongs to the tropomyosin family. (325 aa)
	MYH7	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	COX5A	Cytochrome c oxidase subunit 5A. (117 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
	ACTC1	Actin alpha cardiac muscle 1. (377 aa)
	TPM1	Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (999 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (326 aa)
	COX5B	Cytochrome c oxidase subunit 5B. (128 aa)
	MYL4	Myosin light chain 4. (195 aa)
	CACNA2D2	Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1067 aa)
	CACNB4	GuKc domain-containing protein. (268 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
	COX1	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (513 aa)
	COX2	Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (227 aa)
	COX3	Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (261 aa)
	CYTB	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (381 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	MYH7	ENSSHAP00000019824	ENSSHAP00000017816	Actin alpha cardiac muscle 1.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.936
ACTC1	MYL2	ENSSHAP00000019824	ENSSHAP00000014781	Actin alpha cardiac muscle 1.	Myosin light chain 2.	0.929
ACTC1	MYL3	ENSSHAP00000019824	ENSSHAP00000007416	Actin alpha cardiac muscle 1.	Myosin light chain 3.	0.929
ACTC1	MYL4	ENSSHAP00000019824	ENSSHAP00000020922	Actin alpha cardiac muscle 1.	Myosin light chain 4.	0.929
ACTC1	TPM1	ENSSHAP00000019824	ENSSHAP00000020011	Actin alpha cardiac muscle 1.	Uncharacterized protein; Belongs to the tropomyosin family.	0.944
ACTC1	TPM2	ENSSHAP00000019824	ENSSHAP00000017068	Actin alpha cardiac muscle 1.	Tropomyosin 2; Belongs to the tropomyosin family.	0.944
ACTC1	TPM3	ENSSHAP00000019824	ENSSHAP00000014985	Actin alpha cardiac muscle 1.	Tropomyosin 3; Belongs to the tropomyosin family.	0.944
ACTC1	TPM4	ENSSHAP00000019824	ENSSHAP00000006720	Actin alpha cardiac muscle 1.	Tropomyosin 4; Belongs to the tropomyosin family.	0.944
ASPH	RYR2	ENSSHAP00000001087	ENSSHAP00000011222	Aspartate beta-hydroxylase.	Uncharacterized protein.	0.959
ATP1A1	ATP1A2	ENSSHAP00000020014	ENSSHAP00000010656	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.900
ATP1A1	ATP1B1	ENSSHAP00000020014	ENSSHAP00000006168	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.984
ATP1A1	ATP1B2	ENSSHAP00000020014	ENSSHAP00000018297	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A1	ATP1B3	ENSSHAP00000020014	ENSSHAP00000020044	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A1	ATP1B4	ENSSHAP00000020014	ENSSHAP00000012457	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.954
ATP1A1	FXYD2	ENSSHAP00000020014	ENSSHAP00000005066	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.978
ATP1A2	ATP1A1	ENSSHAP00000010656	ENSSHAP00000020014	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.900
ATP1A2	ATP1B1	ENSSHAP00000010656	ENSSHAP00000006168	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.984
ATP1A2	ATP1B2	ENSSHAP00000010656	ENSSHAP00000018297	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A2	ATP1B3	ENSSHAP00000010656	ENSSHAP00000020044	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A2	ATP1B4	ENSSHAP00000010656	ENSSHAP00000012457	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.954