STRINGSTRING
CALM1-2 CALM1-2 PPP2R1A PPP2R1A KCNQ1 KCNQ1 CAMK2D CAMK2D PIK3R5 PIK3R5 ADCY2 ADCY2 CALML4 CALML4 LOC100934966 LOC100934966 SLC8A1 SLC8A1 GNAI3 GNAI3 ATP2B4 ATP2B4 PPP2R5B PPP2R5B FXYD2 FXYD2 SCN1B SCN1B LOC100929360 LOC100929360 RAPGEF3 RAPGEF3 ATP1B1 ATP1B1 CALML3 CALML3 G3VSR7_SARHA G3VSR7_SARHA PPP1CA PPP1CA ADRA1A ADRA1A MAPK13 MAPK13 ATP2B3 ATP2B3 TPM4 TPM4 ADCY3 ADCY3 ADCY4 ADCY4 GNAI1 GNAI1 MYL3 MYL3 ADRA1B ADRA1B RAPGEF4 RAPGEF4 PPP2R5A PPP2R5A ADCY6 ADCY6 MAPK1 MAPK1 AGTR1 AGTR1 AGTR2 AGTR2 PIK3CG PIK3CG CACNG6 CACNG6 ADCY1 ADCY1 AKT1 AKT1 PPP1CB PPP1CB ATP1A2 ATP1A2 PRKACA PRKACA TNNC1 TNNC1 PRKCA PRKCA RYR2 RYR2 PPP2R5C PPP2R5C GNAQ GNAQ CREB3L3 CREB3L3 ATF6B ATF6B PPP2R2A PPP2R2A PPP2R2B PPP2R2B ATP1B4 ATP1B4 PPP2R5E PPP2R5E MAPK3 MAPK3 ATF2 ATF2 CACNG2 CACNG2 CACNA2D4 CACNA2D4 CREB3L2 CREB3L2 CREB3L4 CREB3L4 PPP2R5D PPP2R5D CACNG3 CACNG3 CACNG4 CACNG4 ADRB2 ADRB2 ATP2A1 ATP2A1 CREB5 CREB5 CACNG1 CACNG1 CACNA2D1 CACNA2D1 PPP1R1A PPP1R1A ADCY9 ADCY9 MYL2 MYL2 TPM3 TPM3 PLCB2 PLCB2 PPP1CC PPP1CC GNAS GNAS CREB1 CREB1 RPS6KA5 RPS6KA5 ATF4 ATF4 CREB3 CREB3 PPP2R1B PPP2R1B SCN4B SCN4B TPM2 TPM2 PPP2R3B PPP2R3B CAMK2B CAMK2B MYH7 MYH7 CACNA1C CACNA1C LOC100913731 LOC100913731 CREB3L1 CREB3L1 ATP1B2 ATP1B2 PLCB1 PLCB1 CACNA1D CACNA1D PPP2CA PPP2CA ACTC1 ACTC1 PPP2R2C PPP2R2C TPM1 TPM1 ATP1A1 ATP1A1 ATP1B3 ATP1B3 CREM CREM PPP2R3A PPP2R3A ATP2B2 ATP2B2 CAMK2A CAMK2A AGT AGT MYL4 MYL4 BCL2 BCL2 G3X039_SARHA G3X039_SARHA GNAI2 GNAI2 CACNA2D2 CACNA2D2 ADCY7 ADCY7 CACNB4 CACNB4 SLC8A3 SLC8A3 G3X3U5_SARHA G3X3U5_SARHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (490 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (329 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
CALML4Calmodulin like 4. (155 aa)
LOC100934966Uncharacterized protein. (127 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (601 aa)
GNAI3G protein subunit alpha i3. (323 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (415 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (72 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
G3VSR7_SARHAUncharacterized protein. (141 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
ADRA1AAdrenoceptor alpha 1A. (465 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1253 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MYL3Myosin light chain 3. (195 aa)
ADRA1BAdrenoceptor alpha 1B. (505 aa)
RAPGEF4Uncharacterized protein. (678 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (450 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (383 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1103 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (256 aa)
ADCY1AC_N domain-containing protein. (214 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP1CBSerine/threonine-protein phosphatase. (268 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (169 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
RYR2Uncharacterized protein. (3999 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (501 aa)
GNAQG protein subunit alpha q. (359 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
ATF6BActivating transcription factor 6 beta. (709 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (444 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (349 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (426 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1084 aa)
CREB3L2BZIP domain-containing protein. (517 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (389 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (253 aa)
ADRB2Adrenoceptor beta 2. (393 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
CREB5Uncharacterized protein. (109 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1085 aa)
PPP1R1AProtein phosphatase 1 regulatory inhibitor subunit 1A. (172 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
MYL2Myosin light chain 2. (171 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (284 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
GNASUncharacterized protein. (320 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
RPS6KA5Ribosomal protein S6 kinase. (808 aa)
ATF4Activating transcription factor 4. (344 aa)
CREB3BZIP domain-containing protein. (370 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (540 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (210 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (325 aa)
PPP2R3BEF-hand domain-containing protein. (541 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PLCB1Phosphoinositide phospholipase C. (1041 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
PPP2CASerine/threonine-protein phosphatase. (333 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (999 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (326 aa)
CREMcAMP responsive element modulator. (425 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1155 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1209 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (484 aa)
MYL4Myosin light chain 4. (195 aa)
BCL2BCL2 apoptosis regulator. (227 aa)
G3X039_SARHASerine/threonine-protein phosphatase. (322 aa)
GNAI2G protein subunit alpha i2. (319 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1067 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
CACNB4GuKc domain-containing protein. (268 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
G3X3U5_SARHACalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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