STRINGSTRING
LOC100919701 LOC100919701 G3VDE6_SARHA G3VDE6_SARHA APC APC CSNK2B CSNK2B PRICKLE1 PRICKLE1 CAMK2D CAMK2D MAPK10 MAPK10 WIF1 WIF1 ROR2 ROR2 CXXC4 CXXC4 FOSL1 FOSL1 FZD2 FZD2 WNT10B WNT10B CCND1 CCND1 PPP3CA PPP3CA CSNK2A2 CSNK2A2 PPP3CB PPP3CB AXIN1 AXIN1 RBX1 RBX1 CCND3 CCND3 FZD6 FZD6 PRICKLE3 PRICKLE3 LOC100929360 LOC100929360 ZNRF3 ZNRF3 WNT8B WNT8B MAPK9 MAPK9 AXIN2 AXIN2 VANGL2 VANGL2 TBL1XR1 TBL1XR1 PPP3R1 PPP3R1 DVL3 DVL3 EP300 EP300 CSNK2A1 CSNK2A1 SOST SOST NFATC4 NFATC4 LOC100919354 LOC100919354 SERPINF1 SERPINF1 WNT5A WNT5A DAAM1 DAAM1 CHD8 CHD8 DVL2 DVL2 CTNNB1 CTNNB1 PRKCB PRKCB NOTUM NOTUM NFATC1 NFATC1 PRKACA PRKACA CCND2 CCND2 FZD4 FZD4 WNT7B WNT7B PRKCA PRKCA WNT5B WNT5B NFATC3 NFATC3 WNT8A WNT8A SMAD4 SMAD4 WNT11 WNT11 RNF43 RNF43 BTRC BTRC CTBP1 CTBP1 WNT7A WNT7A PPARD PPARD CTNNBIP1 CTNNBIP1 DAAM2 DAAM2 RSPO2 RSPO2 SOX17 SOX17 G3WDE9_SARHA G3WDE9_SARHA NLK NLK PSEN1 PSEN1 FBXW11 FBXW11 RSPO1 RSPO1 WNT9A WNT9A MMP7 MMP7 FZD7 FZD7 PRICKLE2 PRICKLE2 LGR4 LGR4 APC2 APC2 FZD5 FZD5 CACYBP CACYBP DKK2 DKK2 PLCB2 PLCB2 NKD2 NKD2 WNT3A WNT3A CREBBP CREBBP LRP6 LRP6 RUVBL1 RUVBL1 WNT9B WNT9B WNT3 WNT3 VANGL1 VANGL1 RAC2 RAC2 WNT16 WNT16 DKK1 DKK1 WNT6 WNT6 CAMK2B CAMK2B CCN4 CCN4 LOC100913731 LOC100913731 SFRP1 SFRP1 TP53 TP53 PLCB1 PLCB1 RYK RYK SIAH1 SIAH1 WNT4 WNT4 RHOA RHOA GPC4 GPC4 FZD10 FZD10 TCF7 TCF7 WNT2B WNT2B WNT2 WNT2 CER1 CER1 TCF7L2 TCF7L2 CAMK2A CAMK2A FZD3 FZD3 TBL1X TBL1X MAPK8 MAPK8 SFRP4 SFRP4 MAP3K7 MAP3K7 CUL1 CUL1 NFATC2 NFATC2 G3X1Y7_SARHA G3X1Y7_SARHA FZD1 FZD1 PPP3CC PPP3CC RSPO3 RSPO3 NKD1 NKD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100919701Uncharacterized protein. (127 aa)
G3VDE6_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
APCUncharacterized protein. (2704 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (234 aa)
PRICKLE1Prickle planar cell polarity protein 1. (826 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
WIF1WNT inhibitory factor 1. (283 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1022 aa)
CXXC4CXXC finger protein 4. (190 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (174 aa)
FZD2G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (235 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
PPP3CASerine/threonine-protein phosphatase. (502 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (320 aa)
PPP3CBSerine/threonine-protein phosphatase. (501 aa)
AXIN1Axin 1. (875 aa)
RBX1Ring-box 1. (108 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (234 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (718 aa)
PRICKLE3Uncharacterized protein. (499 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
ZNRF3ZNRF_3_ecto domain-containing protein. (60 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
AXIN2Axin 2. (837 aa)
VANGL2Vang-like protein. (587 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (516 aa)
PPP3R1Uncharacterized protein. (170 aa)
DVL3Uncharacterized protein. (272 aa)
EP300E1A binding protein p300. (1895 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
SOSTSclerostin. (212 aa)
NFATC4Nuclear factor of activated T cells 4. (875 aa)
LOC100919354Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (325 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (419 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1078 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2594 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (517 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
CCND2CYCLIN domain-containing protein; Belongs to the cyclin family. (141 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (448 aa)
NFATC3Nuclear factor of activated T cells 3. (1052 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RNF43RING-type domain-containing protein. (778 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (634 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (439 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (293 aa)
PPARDPeroxisome proliferator activated receptor delta. (442 aa)
CTNNBIP1Catenin beta interacting protein 1. (63 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1043 aa)
RSPO2R-spondin 2. (243 aa)
SOX17Uncharacterized protein. (399 aa)
G3WDE9_SARHASox C-terminal domain-containing protein. (105 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (444 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
FBXW11F-box and WD repeat domain containing 11. (510 aa)
RSPO1R-spondin 1. (262 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
MMP7ZnMc domain-containing protein. (264 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
PRICKLE2Prickle planar cell polarity protein 2. (856 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (889 aa)
APC2APC regulator of WNT signaling pathway 2. (2196 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
CACYBPCalcyclin binding protein. (229 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (272 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (457 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (248 aa)
CREBBPCREB binding protein. (2452 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (409 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
VANGL1Vang-like protein. (500 aa)
RAC2Rac family small GTPase 2. (192 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
DKK1Uncharacterized protein. (138 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
CCN4Cellular communication network factor 4. (371 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
PLCB1Phosphoinositide phospholipase C. (1041 aa)
RYKReceptor like tyrosine kinase. (531 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (264 aa)
RHOAUncharacterized protein. (193 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (527 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
TCF7HMG box domain-containing protein. (266 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
CER1Cerberus 1, DAN family BMP antagonist. (259 aa)
TCF7L2Transcription factor 7 like 2. (471 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
TBL1XUncharacterized protein. (512 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
SFRP4NTR domain-containing protein. (137 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
NFATC2Nuclear factor of activated T cells 2. (703 aa)
G3X1Y7_SARHAUncharacterized protein. (223 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (339 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
RSPO3R-spondin 3. (279 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (376 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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