STRINGSTRING
DTX3L DTX3L JAG2 JAG2 DTX4 DTX4 LOC100932860 LOC100932860 RBPJ RBPJ NCOR2 NCOR2 KAT2A KAT2A DVL3 DVL3 ADAM17 ADAM17 EP300 EP300 NCSTN NCSTN DTX3 DTX3 KAT2B KAT2B DVL2 DVL2 APH1A APH1A PSENEN PSENEN PSEN2 PSEN2 HDAC1 HDAC1 CTBP1 CTBP1 MAML1 MAML1 DTX2 DTX2 MAML3 MAML3 NUMB NUMB MAML2 MAML2 HDAC2 HDAC2 LFNG LFNG PSEN1 PSEN1 RBPJL RBPJL CREBBP CREBBP DLL1 DLL1 CIR1 CIR1 DTX1 DTX1 NOTCH2 NOTCH2 MFNG MFNG DLL4 DLL4 HEY2 HEY2 ATXN1L ATXN1L APH1B APH1B HEY1 HEY1 HEYL HEYL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DTX3LRING-type domain-containing protein. (754 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
DTX4RING-type domain-containing protein. (321 aa)
LOC100932860SKIP_SNW domain-containing protein. (536 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (465 aa)
NCOR2Nuclear receptor corepressor 2. (2437 aa)
KAT2ALysine acetyltransferase 2A. (725 aa)
DVL3Uncharacterized protein. (272 aa)
ADAM17ADAM metallopeptidase domain 17. (791 aa)
EP300E1A binding protein p300. (1895 aa)
NCSTNNicastrin. (680 aa)
DTX3Deltex E3 ubiquitin ligase 3. (347 aa)
KAT2BLysine acetyltransferase 2B. (710 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (227 aa)
PSENENUncharacterized protein. (81 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (462 aa)
HDAC1Hist_deacetyl domain-containing protein. (323 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (439 aa)
MAML1Mastermind like transcriptional coactivator 1. (920 aa)
DTX2RING-type domain-containing protein. (409 aa)
MAML3Uncharacterized protein. (441 aa)
NUMBNUMB endocytic adaptor protein. (607 aa)
MAML2Uncharacterized protein. (438 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (473 aa)
LFNGUncharacterized protein. (242 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (509 aa)
CREBBPCREB binding protein. (2452 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (733 aa)
CIR1Corepressor interacting with RBPJ, 1. (476 aa)
DTX1Deltex E3 ubiquitin ligase 1. (626 aa)
NOTCH2Notch receptor 2. (2406 aa)
MFNGMFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (241 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (691 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (340 aa)
ATXN1LAtaxin 1 like. (695 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (258 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (309 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (324 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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