(66 nodes) IL-17 signaling pathway network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
	IL17RA	SEFIR domain-containing protein. (675 aa)
	G3VBX3_SARHA	SCY domain-containing protein. (94 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
	FADD	Uncharacterized protein. (193 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (803 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (174 aa)
	SRSF1	Uncharacterized protein. (249 aa)
	LOC100922240	SCY domain-containing protein. (105 aa)
	MUC5AC	Uncharacterized protein. (1745 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (321 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	IL17D	Interleukin 17D. (210 aa)
	MAPK9	Mitogen-activated protein kinase. (429 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	IL17C	Uncharacterized protein. (199 aa)
	MMP9	Matrix metallopeptidase 9. (717 aa)
	TBK1	TANK binding kinase 1. (732 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (980 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	MAPK1	Mitogen-activated protein kinase. (348 aa)
	G3W0M1_SARHA	Protein S100; Belongs to the S-100 family. (113 aa)
	HSP90AA1	HATPase_c domain-containing protein. (731 aa)
	LCN2	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (196 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
	IL17B	Interleukin 17B. (197 aa)
	CASP3	Uncharacterized protein; Belongs to the peptidase C14A family. (275 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	CCL20	SCY domain-containing protein. (115 aa)
	G3W651_SARHA	Uncharacterized protein; Belongs to the peptidase C14A family. (282 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (566 aa)
	TNFAIP3	TNF alpha induced protein 3. (792 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
	MAPK3	Mitogen-activated protein kinase. (375 aa)
	IL6	Uncharacterized protein. (212 aa)
	IL4	Uncharacterized protein. (156 aa)
	IL17A	Interleukin 17A. (154 aa)
	MAPK4	Mitogen-activated protein kinase 4. (579 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (783 aa)
	G3WKU6_SARHA	C-C motif chemokine. (143 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
	CSF3	Colony stimulating factor 3. (221 aa)
	MMP1	Matrix metallopeptidase 1. (473 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (579 aa)
	MMP3	Matrix metallopeptidase 3. (474 aa)
	TRAF4	TNF receptor associated factor 4. (318 aa)
	MMP13	Matrix metallopeptidase 13. (474 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
	CCL17	SCY domain-containing protein. (136 aa)
	IL17RE	Uncharacterized protein. (433 aa)
	IL17RC	SEFIR domain-containing protein. (534 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (609 aa)
	G3WUN3_SARHA	C-X-C motif chemokine. (117 aa)
	IL17RB	IL17R_fnIII_D1 domain-containing protein. (143 aa)
	ANAPC5	Anaphase promoting complex subunit 5. (672 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (694 aa)
	MAPK6	Protein kinase domain-containing protein. (722 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (723 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (727 aa)
	MAPK8	Mitogen-activated protein kinase. (429 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (716 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CASP8	ENSSHAP00000010635	ENSSHAP00000000850	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.972
CASP3	FADD	ENSSHAP00000010635	ENSSHAP00000001225	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.704
CASP3	G3W651_SARHA	ENSSHAP00000010635	ENSSHAP00000010906	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.900
CASP3	IL1B	ENSSHAP00000010635	ENSSHAP00000010316	Uncharacterized protein; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.550
CASP3	IL6	ENSSHAP00000010635	ENSSHAP00000013156	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.519
CASP3	MAPK1	ENSSHAP00000010635	ENSSHAP00000008915	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase.	0.930
CASP3	MAPK3	ENSSHAP00000010635	ENSSHAP00000012745	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase.	0.930
CASP3	MMP9	ENSSHAP00000010635	ENSSHAP00000006723	Uncharacterized protein; Belongs to the peptidase C14A family.	Matrix metallopeptidase 9.	0.404
CASP3	NFKB1	ENSSHAP00000010635	ENSSHAP00000008514	Uncharacterized protein; Belongs to the peptidase C14A family.	Nuclear factor kappa B subunit 1.	0.412
CASP8	CASP3	ENSSHAP00000000850	ENSSHAP00000010635	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.972
CASP8	FADD	ENSSHAP00000000850	ENSSHAP00000001225	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.994
CASP8	G3W651_SARHA	ENSSHAP00000000850	ENSSHAP00000010906	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.972
CASP8	IL1B	ENSSHAP00000000850	ENSSHAP00000010316	Uncharacterized protein; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.577
CASP8	IL6	ENSSHAP00000000850	ENSSHAP00000013156	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.425
CASP8	MAP3K7	ENSSHAP00000000850	ENSSHAP00000020843	Uncharacterized protein; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.433
CASP8	TRAF2	ENSSHAP00000000850	ENSSHAP00000008747	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.672
CASP8	TRAF3	ENSSHAP00000000850	ENSSHAP00000010648	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.540
CASP8	TRAF5	ENSSHAP00000000850	ENSSHAP00000016798	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.536
CASP8	TRAF6	ENSSHAP00000000850	ENSSHAP00000016327	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.600
CCL17	CCL20	ENSSHAP00000017898	ENSSHAP00000010708	SCY domain-containing protein.	SCY domain-containing protein.	0.429