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PIK3CB PIK3CB SOCS1 SOCS1 CALM1-2 CALM1-2 PYGL PYGL CRKL CRKL SHC3 SHC3 PPP1R3B PPP1R3B MAPK10 MAPK10 RPS6KB2 RPS6KB2 PHKA2 PHKA2 CALML4 CALML4 PRKAG1 PRKAG1 SOCS2 SOCS2 SOS2 SOS2 LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA SOCS4 SOCS4 RHEB RHEB MKNK1 MKNK1 HK1 HK1 TRIP10 TRIP10 SHC1 SHC1 FOXO1 FOXO1 LOC100929360 LOC100929360 TSC1 TSC1 PPP1R3D PPP1R3D CALML3 CALML3 RPS6 RPS6 PPP1CA PPP1CA MAPK9 MAPK9 PRKAG2 PRKAG2 ARAF ARAF INPPL1 INPPL1 INSR INSR PRKCZ PRKCZ PHKA1 PHKA1 MAPK1 MAPK1 PDPK1 PDPK1 SLC2A4 SLC2A4 EIF4E1B EIF4E1B FLOT1 FLOT1 CBL CBL PRKAR1A PRKAR1A PIK3R1 PIK3R1 MKNK2 MKNK2 EIF4E EIF4E RPTOR RPTOR PKLR PKLR PRKAA2 PRKAA2 AKT1 AKT1 PPP1CB PPP1CB PRKACA PRKACA MAP2K2 MAP2K2 G3W697_SARHA G3W697_SARHA PHKG2 PHKG2 PIK3R2 PIK3R2 HK2 HK2 PPARGC1A PPARGC1A HK3 HK3 ACACB ACACB PRKAR1B PRKAR1B RHOQ RHOQ MAPK3 MAPK3 RAF1 RAF1 IRS4 IRS4 SHC2 SHC2 PRKAR2B PRKAR2B ACACA ACACA PHKB PHKB PCK1 PCK1 G3WI87_SARHA G3WI87_SARHA EIF4E2 EIF4E2 PRKAR2A PRKAR2A PPP1CC PPP1CC CBLB CBLB PRKAA1 PRKAA1 IRS1 IRS1 GCK GCK SOS1 SOS1 G6PC3 G6PC3 PRKCI PRKCI LOC100913731 LOC100913731 PRKAG3 PRKAG3 SHC4 SHC4 GYS2 GYS2 TSC2 TSC2 RPS6KB1 RPS6KB1 LOC100927896 LOC100927896 PIK3CA PIK3CA PCK2 PCK2 PHKG1 PHKG1 PRKAB2 PRKAB2 MAPK8 MAPK8 PYGB PYGB IKBKB IKBKB SOCS3 SOCS3 PRKAB1 PRKAB1 GRB2 GRB2 PPP1R3C PPP1R3C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
SOCS1Suppressor of cytokine signaling 1. (154 aa)
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (626 aa)
CRKLCRK like proto-oncogene, adaptor protein. (194 aa)
SHC3SHC adaptor protein 3. (422 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (473 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1161 aa)
CALML4Calmodulin like 4. (155 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (327 aa)
SOCS2Suppressor of cytokine signaling 2. (199 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1329 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
SOCS4Suppressor of cytokine signaling 4. (439 aa)
RHEBRas homolog, mTORC1 binding. (191 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
HK1Hexokinase 1. (922 aa)
TRIP10Thyroid hormone receptor interactor 10. (603 aa)
SHC1SHC adaptor protein 1. (569 aa)
FOXO1Fork-head domain-containing protein. (145 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
TSC1TSC complex subunit 1. (1017 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (301 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
PRKAG2Uncharacterized protein. (283 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (627 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (958 aa)
INSRFibronectin type-III domain-containing protein. (535 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (453 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1229 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PDPK1Protein kinase domain-containing protein. (558 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (200 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
CBLCbl proto-oncogene. (774 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (383 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MKNK2MAPK interacting serine/threonine kinase 2. (369 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1056 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (586 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP1CBSerine/threonine-protein phosphatase. (268 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
G3W697_SARHAFBPase domain-containing protein; Belongs to the FBPase class 1 family. (342 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (403 aa)
PIK3R2Uncharacterized protein. (738 aa)
HK2Hexokinase 2. (917 aa)
PPARGC1APPARG coactivator 1 alpha. (826 aa)
HK3Hexokinase 3. (803 aa)
ACACBAcetyl-CoA carboxylase beta. (2348 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (329 aa)
RHOQRas homolog family member Q. (205 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
IRS4IRS-type PTB domain-containing protein. (870 aa)
SHC2Uncharacterized protein. (479 aa)
PRKAR2BUncharacterized protein. (190 aa)
ACACAUncharacterized protein. (1208 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1070 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (624 aa)
G3WI87_SARHAFBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (318 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
CBLBCbl proto-oncogene B. (985 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
GCKPhosphotransferase. (468 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (350 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (569 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (470 aa)
SHC4SHC adaptor protein 4. (538 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (701 aa)
TSC2TSC complex subunit 2. (1830 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (527 aa)
LOC100927896CBM21 domain-containing protein. (219 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (242 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (763 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
SOCS3Suppressor of cytokine signaling 3. (228 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
GRB2Growth factor receptor bound protein 2. (191 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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