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CALM1-2 CALM1-2 PRKD2 PRKD2 CAMK2D CAMK2D SCARB1 SCARB1 ADCY2 ADCY2 CALML4 CALML4 ATP2B4 ATP2B4 ATF1 ATF1 LOC100929360 LOC100929360 KCNK9 KCNK9 ATP1B1 ATP1B1 CALML3 CALML3 CACNA1G CACNA1G ATP2B3 ATP2B3 ADCY3 ADCY3 GNA11 GNA11 ITPR3 ITPR3 ADCY4 ADCY4 ADCY6 ADCY6 AGTR1 AGTR1 PRKCB PRKCB NPPA NPPA ADCY1 ADCY1 KCNK3 KCNK3 ATP1A2 ATP1A2 PRKACA PRKACA PDE2A PDE2A LDLR LDLR CYP21A2 CYP21A2 PRKCA PRKCA PRKD3 PRKD3 CAMK1G CAMK1G GNAQ GNAQ CREB3L3 CREB3L3 ATF6B ATF6B NPR1 NPR1 ATP1B4 ATP1B4 DAGLB DAGLB ATF2 ATF2 CREB3L2 CREB3L2 CREB3L4 CREB3L4 CREB5 CREB5 ADCY9 ADCY9 NR4A1 NR4A1 ITPR1 ITPR1 NR4A2 NR4A2 CAMK1D CAMK1D CYP11A1 CYP11A1 PLCB2 PLCB2 GNAS GNAS CREB1 CREB1 ATF4 ATF4 CREB3 CREB3 HSD3B2 HSD3B2 CAMK2B CAMK2B CACNA1C CACNA1C LOC100913731 LOC100913731 CREB3L1 CREB3L1 ATP1B2 ATP1B2 PLCB1 PLCB1 MC2R MC2R CACNA1D CACNA1D ATP1A1 ATP1A1 ATP1B3 ATP1B3 STAR STAR ATP2B2 ATP2B2 CAMK2A CAMK2A AGT AGT KCNJ5 KCNJ5 ADCY7 ADCY7 G3X3U5_SARHA G3X3U5_SARHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PRKD2Uncharacterized protein. (558 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (545 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
CALML4Calmodulin like 4. (155 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
ATF1Uncharacterized protein. (313 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2397 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1253 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
GNA11G protein subunit alpha 11. (316 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2665 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
NPPANatriuretic peptide A. (144 aa)
ADCY1AC_N domain-containing protein. (214 aa)
KCNK3Potassium two pore domain channel subfamily K member 3. (276 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
PDE2APhosphodiesterase. (835 aa)
LDLRLow density lipoprotein receptor. (865 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (482 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (891 aa)
CAMK1GProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa)
GNAQG protein subunit alpha q. (359 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
ATF6BActivating transcription factor 6 beta. (709 aa)
NPR1Guanylate cyclase. (1013 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (349 aa)
DAGLBDiacylglycerol lipase beta. (738 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
CREB3L2BZIP domain-containing protein. (517 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (389 aa)
CREB5Uncharacterized protein. (109 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2696 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (609 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (298 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (524 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
GNASUncharacterized protein. (320 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
ATF4Activating transcription factor 4. (344 aa)
CREB3BZIP domain-containing protein. (370 aa)
HSD3B23Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (377 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PLCB1Phosphoinositide phospholipase C. (1041 aa)
MC2RMelanocortin 2 receptor. (304 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (999 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (326 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1209 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (484 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (421 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
G3X3U5_SARHACalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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