96 items (Sarcophilus harrisii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
	ARRB2	Arrestin beta 2. (409 aa)
	SHC3	SHC adaptor protein 3. (422 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (524 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	ADCY2	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
	RXFP2	Relaxin family peptide receptor 2. (754 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (321 aa)
	GNAI3	G protein subunit alpha i3. (323 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1329 aa)
	LOC100929426	Uncharacterized protein. (200 aa)
	G3VMA8_SARHA	Uncharacterized protein. (192 aa)
	GNGT1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	LOC100920799	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	INSL3	IlGF domain-containing protein. (141 aa)
	SHC1	SHC adaptor protein 1. (569 aa)
	LOC100929360	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	RXFP3	Relaxin family peptide receptor 3. (464 aa)
	COL1A2	Collagen type I alpha 2 chain. (1332 aa)
	COL3A1	Collagen type III alpha 1 chain. (1464 aa)
	MAPK9	Mitogen-activated protein kinase. (429 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	MMP9	Matrix metallopeptidase 9. (717 aa)
	ADCY3	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (162 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	GNAO1	G protein subunit alpha o1. (354 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (980 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. (453 aa)
	FBXO21	F-box protein 21. (542 aa)
	MAPK1	Mitogen-activated protein kinase. (348 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (433 aa)
	LOC100914671	Uncharacterized protein; Belongs to the actin family. (391 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	GNB2	G protein subunit beta 2. (340 aa)
	ADCY1	AC_N domain-containing protein. (214 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	NOS3	Nitric oxide synthase 3. (1022 aa)
	PRKACA	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1732 aa)
	PIK3R2	Uncharacterized protein. (738 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (465 aa)
	ATF6B	Activating transcription factor 6 beta. (709 aa)
	MAPK3	Mitogen-activated protein kinase. (375 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
	SHC2	Uncharacterized protein. (479 aa)
	CREB3L2	BZIP domain-containing protein. (517 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1671 aa)
	COL4A5	Collagen IV NC1 domain-containing protein. (1284 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (389 aa)
	ARRB1	Arrestin beta 1. (418 aa)
	MMP2	Matrix metallopeptidase 2. (665 aa)
	CREB5	Uncharacterized protein. (109 aa)
	COL4A3	Collagen type IV alpha 3 chain. (1674 aa)
	GNB1	G protein subunit beta 1. (340 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (409 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	COL4A4	Collagen type IV alpha 4 chain. (1427 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
	COL1A1	Collagen type I alpha 1 chain. (1475 aa)
	RXFP1	Relaxin family peptide receptor 1. (696 aa)
	GNAS	Uncharacterized protein. (320 aa)
	VEGFC	Uncharacterized protein. (236 aa)
	GNG13	G protein subunit gamma 13. (67 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	ATF4	Activating transcription factor 4. (344 aa)
	MMP1	Matrix metallopeptidase 1. (473 aa)
	CREB3	BZIP domain-containing protein. (370 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
	MMP13	Matrix metallopeptidase 13. (474 aa)
	EDN1	Endothelin 1. (214 aa)
	LOC100913731	Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (526 aa)
	SHC4	SHC adaptor protein 4. (538 aa)
	PLCB1	Phosphoinositide phospholipase C. (1041 aa)
	GNB3	G protein subunit beta 3. (340 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (475 aa)
	GNB4	G protein subunit beta 4. (340 aa)
	GNB5	G protein subunit beta 5. (395 aa)
	SRC	Tyrosine-protein kinase. (533 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	MAPK8	Mitogen-activated protein kinase. (429 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
	GRB2	Growth factor receptor bound protein 2. (191 aa)
	GNAI2	G protein subunit alpha i2. (319 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSSHAP00000010177	ENSSHAP00000002916	AC_N domain-containing protein.	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.727
ADCY1	ADCY3	ENSSHAP00000010177	ENSSHAP00000006958	AC_N domain-containing protein.	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.935
ADCY1	ADCY9	ENSSHAP00000010177	ENSSHAP00000014749	AC_N domain-containing protein.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.529
ADCY1	AKT1	ENSSHAP00000010177	ENSSHAP00000010374	AC_N domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.911
ADCY1	GNAI1	ENSSHAP00000010177	ENSSHAP00000007296	AC_N domain-containing protein.	G protein subunit alpha i1.	0.780
ADCY1	GNAI2	ENSSHAP00000010177	ENSSHAP00000022007	AC_N domain-containing protein.	G protein subunit alpha i2.	0.780
ADCY1	GNAI3	ENSSHAP00000010177	ENSSHAP00000003818	AC_N domain-containing protein.	G protein subunit alpha i3.	0.780
ADCY1	GNAO1	ENSSHAP00000010177	ENSSHAP00000007802	AC_N domain-containing protein.	G protein subunit alpha o1.	0.937
ADCY1	GNAS	ENSSHAP00000010177	ENSSHAP00000015821	AC_N domain-containing protein.	Uncharacterized protein.	0.956
ADCY1	GNB1	ENSSHAP00000010177	ENSSHAP00000014466	AC_N domain-containing protein.	G protein subunit beta 1.	0.759
ADCY1	GNB2	ENSSHAP00000010177	ENSSHAP00000010137	AC_N domain-containing protein.	G protein subunit beta 2.	0.759
ADCY1	GNB3	ENSSHAP00000010177	ENSSHAP00000018857	AC_N domain-containing protein.	G protein subunit beta 3.	0.759
ADCY1	GNB4	ENSSHAP00000010177	ENSSHAP00000019978	AC_N domain-containing protein.	G protein subunit beta 4.	0.759
ADCY1	GNB5	ENSSHAP00000010177	ENSSHAP00000020421	AC_N domain-containing protein.	G protein subunit beta 5.	0.807
ADCY1	GNG12	ENSSHAP00000010177	ENSSHAP00000002683	AC_N domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.800
ADCY1	GNG13	ENSSHAP00000010177	ENSSHAP00000016215	AC_N domain-containing protein.	G protein subunit gamma 13.	0.815
ADCY1	GNG5	ENSSHAP00000010177	ENSSHAP00000020698	AC_N domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.802
ADCY1	GNG8	ENSSHAP00000010177	ENSSHAP00000002168	AC_N domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.774
ADCY1	GNGT1	ENSSHAP00000010177	ENSSHAP00000004750	AC_N domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.770
ADCY1	LOC100913731	ENSSHAP00000010177	ENSSHAP00000017911	AC_N domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.918