STRINGSTRING
SCARB1 SCARB1 ADCY2 ADCY2 SP1 SP1 LOC100929360 LOC100929360 NR0B1 NR0B1 CACNA1G CACNA1G ADCY3 ADCY3 GNA11 GNA11 ITPR3 ITPR3 ADCY4 ADCY4 MRAP MRAP ADCY6 ADCY6 AGTR1 AGTR1 G3W116_SARHA G3W116_SARHA KCNA4 KCNA4 ADCY1 ADCY1 KCNK3 KCNK3 PRKACA PRKACA LDLR LDLR CYP21A2 CYP21A2 NCEH1 NCEH1 GNAQ GNAQ CREB3L3 CREB3L3 ATF6B ATF6B ATF2 ATF2 CREB3L2 CREB3L2 CREB3L4 CREB3L4 CREB5 CREB5 ADCY9 ADCY9 NR4A1 NR4A1 ITPR1 ITPR1 PBX1 PBX1 CYP11A1 CYP11A1 PLCB2 PLCB2 GNAS GNAS CREB1 CREB1 ATF4 ATF4 CREB3 CREB3 HSD3B2 HSD3B2 CACNA1C CACNA1C LOC100913731 LOC100913731 CREB3L1 CREB3L1 PLCB1 PLCB1 MC2R MC2R CACNA1D CACNA1D NR5A1 NR5A1 PDE8A PDE8A STAR STAR AGT AGT PDE8B PDE8B KCNK2 KCNK2 CYP17A1 CYP17A1 ADCY7 ADCY7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (545 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
SP1Sp1 transcription factor. (553 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
NR0B1NR LBD domain-containing protein. (208 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2397 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
GNA11G protein subunit alpha 11. (316 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2665 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
MRAPUncharacterized protein. (93 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
G3W116_SARHAUncharacterized protein; Belongs to the cytochrome P450 family. (517 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (606 aa)
ADCY1AC_N domain-containing protein. (214 aa)
KCNK3Potassium two pore domain channel subfamily K member 3. (276 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
LDLRLow density lipoprotein receptor. (865 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (482 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (416 aa)
GNAQG protein subunit alpha q. (359 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
ATF6BActivating transcription factor 6 beta. (709 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
CREB3L2BZIP domain-containing protein. (517 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (389 aa)
CREB5Uncharacterized protein. (109 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2696 aa)
PBX1PBX homeobox 1. (342 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (524 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
GNASUncharacterized protein. (320 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
ATF4Activating transcription factor 4. (344 aa)
CREB3BZIP domain-containing protein. (370 aa)
HSD3B23Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (377 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
PLCB1Phosphoinositide phospholipase C. (1041 aa)
MC2RMelanocortin 2 receptor. (304 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (392 aa)
PDE8APhosphodiesterase. (769 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (484 aa)
PDE8BPhosphodiesterase. (760 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (322 aa)
CYP17A1Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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