(29 nodes) Aldosterone-regulated sodium reabsorption network (Sarcophilus harrisii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
	LOC100929426	Uncharacterized protein. (200 aa)
	G3VMA8_SARHA	Uncharacterized protein. (192 aa)
	FXYD2	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (72 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
	NR3C2	Uncharacterized protein. (594 aa)
	INSR	Fibronectin type-III domain-containing protein. (535 aa)
	MAPK1	Mitogen-activated protein kinase. (348 aa)
	PDPK1	Protein kinase domain-containing protein. (558 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
	IGF1	Insulin like growth factor 1. (130 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (658 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
	PIK3R2	Uncharacterized protein. (738 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (349 aa)
	MAPK3	Mitogen-activated protein kinase. (375 aa)
	SCNN1A	Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (588 aa)
	IRS1	Insulin receptor substrate 1. (1234 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	SLC9A3R2	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (346 aa)
	NEDD4L	E3 ubiquitin-protein ligase. (881 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (999 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (326 aa)
	KCNJ1	Potassium voltage-gated channel subfamily J member 1. (391 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1A1	ATP1A2	ENSSHAP00000020014	ENSSHAP00000010656	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.900
ATP1A1	ATP1B1	ENSSHAP00000020014	ENSSHAP00000006168	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.984
ATP1A1	ATP1B2	ENSSHAP00000020014	ENSSHAP00000018297	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A1	ATP1B3	ENSSHAP00000020014	ENSSHAP00000020044	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A1	ATP1B4	ENSSHAP00000020014	ENSSHAP00000012457	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.954
ATP1A1	FXYD2	ENSSHAP00000020014	ENSSHAP00000005066	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.978
ATP1A1	MAPK1	ENSSHAP00000020014	ENSSHAP00000008915	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.910
ATP1A1	MAPK3	ENSSHAP00000020014	ENSSHAP00000012745	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.910
ATP1A2	ATP1A1	ENSSHAP00000010656	ENSSHAP00000020014	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.900
ATP1A2	ATP1B1	ENSSHAP00000010656	ENSSHAP00000006168	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.984
ATP1A2	ATP1B2	ENSSHAP00000010656	ENSSHAP00000018297	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A2	ATP1B3	ENSSHAP00000010656	ENSSHAP00000020044	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A2	ATP1B4	ENSSHAP00000010656	ENSSHAP00000012457	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.954
ATP1A2	FXYD2	ENSSHAP00000010656	ENSSHAP00000005066	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.978
ATP1A2	MAPK1	ENSSHAP00000010656	ENSSHAP00000008915	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.910
ATP1A2	MAPK3	ENSSHAP00000010656	ENSSHAP00000012745	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.910
ATP1B1	ATP1A1	ENSSHAP00000006168	ENSSHAP00000020014	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit alpha.	0.984
ATP1B1	ATP1A2	ENSSHAP00000006168	ENSSHAP00000010656	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit alpha.	0.984
ATP1B1	ATP1B2	ENSSHAP00000006168	ENSSHAP00000018297	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.958
ATP1B1	ATP1B3	ENSSHAP00000006168	ENSSHAP00000020044	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.949