43 items (Sarcophilus harrisii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOE	Uncharacterized protein. (256 aa)
	SOAT2	O-acyltransferase. (521 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (545 aa)
	APOC2	Uncharacterized protein. (100 aa)
	TSPO	Translocator protein. (168 aa)
	SOAT1	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (265 aa)
	PLTP	Phospholipid transfer protein. (511 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (881 aa)
	LIPG	Lipase G, endothelial type. (407 aa)
	APOH	Apolipoprotein H. (345 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (621 aa)
	LIPC	Lipase C, hepatic type. (508 aa)
	LRP1	LDL receptor related protein 1. (3514 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2264 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (446 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (473 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (473 aa)
	VAPA	VAMP associated protein A. (249 aa)
	LDLR	Low density lipoprotein receptor. (865 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (416 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1192 aa)
	VDAC2	Voltage dependent anion channel 2. (293 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (507 aa)
	APOA1	Uncharacterized protein. (267 aa)
	APOC3	Uncharacterized protein. (98 aa)
	APOA4	Uncharacterized protein. (350 aa)
	LRPAP1	LDL receptor related protein associated protein 1. (381 aa)
	STARD3	StAR related lipid transfer domain containing 3. (449 aa)
	VAPB	VAMP associated protein B and C. (240 aa)
	APOA2	Apolipoprotein A2. (102 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1323 aa)
	LRP2	Uncharacterized protein. (3969 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	VDAC1	Voltage dependent anion channel 1. (298 aa)
	TSPO2	Translocator protein 2. (177 aa)
	VDAC3	Voltage dependent anion channel 3. (284 aa)
	SORT1	Sortilin. (730 aa)
	ANGPTL3	Angiopoietin like 3. (462 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (416 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (150 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (648 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (648 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA1	ENSSHAP00000008645	ENSSHAP00000015521	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.929
ABCA1	APOE	ENSSHAP00000008645	ENSSHAP00000001460	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.431
ABCB11	CYP7A1	ENSSHAP00000019694	ENSSHAP00000015489	ATP binding cassette subfamily B member 11.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.597
ABCG5	ABCG8	ENSSHAP00000022205	ENSSHAP00000022184	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	CYP7A1	ENSSHAP00000022205	ENSSHAP00000015489	ATP binding cassette subfamily G member 5.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.612
ABCG5	NPC1	ENSSHAP00000022205	ENSSHAP00000013409	ATP binding cassette subfamily G member 5.	NPC intracellular cholesterol transporter 1.	0.408
ABCG8	ABCG5	ENSSHAP00000022184	ENSSHAP00000022205	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	CYP7A1	ENSSHAP00000022184	ENSSHAP00000015489	ATP binding cassette subfamily G member 8.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.593
ANGPTL3	APOC3	ENSSHAP00000021711	ENSSHAP00000015555	Angiopoietin like 3.	Uncharacterized protein.	0.472
ANGPTL3	LIPG	ENSSHAP00000021711	ENSSHAP00000005621	Angiopoietin like 3.	Lipase G, endothelial type.	0.417
ANGPTL3	LPL	ENSSHAP00000021711	ENSSHAP00000009403	Angiopoietin like 3.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.969
ANGPTL3	PCSK9	ENSSHAP00000021711	ENSSHAP00000006776	Angiopoietin like 3.	Proprotein convertase subtilisin/kexin type 9.	0.435
APOA1	ABCA1	ENSSHAP00000015521	ENSSHAP00000008645	Uncharacterized protein.	ATP binding cassette subfamily A member 1.	0.929
APOA1	APOA2	ENSSHAP00000015521	ENSSHAP00000019632	Uncharacterized protein.	Apolipoprotein A2.	0.739
APOA1	APOA4	ENSSHAP00000015521	ENSSHAP00000015615	Uncharacterized protein.	Uncharacterized protein.	0.825
APOA1	APOC2	ENSSHAP00000015521	ENSSHAP00000002704	Uncharacterized protein.	Uncharacterized protein.	0.522
APOA1	APOC3	ENSSHAP00000015521	ENSSHAP00000015555	Uncharacterized protein.	Uncharacterized protein.	0.656
APOA1	APOE	ENSSHAP00000015521	ENSSHAP00000001460	Uncharacterized protein.	Uncharacterized protein.	0.876
APOA1	APOH	ENSSHAP00000015521	ENSSHAP00000006298	Uncharacterized protein.	Apolipoprotein H.	0.455
APOA1	CETP	ENSSHAP00000015521	ENSSHAP00000015145	Uncharacterized protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.677