STRINGSTRING
CHUK CHUK PIK3CB PIK3CB PSMD8 PSMD8 CALM1-2 CALM1-2 ATP5PO ATP5PO PSMD7 PSMD7 CASP8 CASP8 NDUFB7 NDUFB7 SLC25A4 SLC25A4 G3VDE6_SARHA G3VDE6_SARHA FADD FADD APC APC G3VDR7_SARHA G3VDR7_SARHA APOE APOE ATP5MC3 ATP5MC3 EIF2AK2 EIF2AK2 CSNK2B CSNK2B NDUFA13 NDUFA13 ATP5F1D ATP5F1D RTN3 RTN3 MAP2K7 MAP2K7 MAPK10 MAPK10 APP APP LOC100921951 LOC100921951 FZD2 FZD2 PSMC4 PSMC4 G3VHY9_SARHA G3VHY9_SARHA WNT10B WNT10B ATP5F1B ATP5F1B CALML4 CALML4 PSMB6 PSMB6 NDUFA4L2 NDUFA4L2 NDUFV2 NDUFV2 FAS FAS ULK2 ULK2 NDUFA11 NDUFA11 PPP3CA PPP3CA CSNK2A2 CSNK2A2 PPP3CB PPP3CB LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA AXIN1 AXIN1 TNF TNF PSMC2 PSMC2 CSF1 CSF1 NAE1 NAE1 NDUFA9 NDUFA9 PSMD1 PSMD1 FZD6 FZD6 NDUFA10 NDUFA10 NRBF2 NRBF2 NOX4 NOX4 BACE2 BACE2 WNT8B WNT8B LOC100919671 LOC100919671 LOC100934740 LOC100934740 CALML3 CALML3 COX4I1 COX4I1 MAPK9 MAPK9 PSMA2 PSMA2 AXIN2 AXIN2 NDUFV1 NDUFV1 ATP5MC2 ATP5MC2 PSMD9 PSMD9 GRM5 GRM5 HSD17B10 HSD17B10 CYC1 CYC1 PPP3R1 PPP3R1 DVL3 DVL3 ARAF ARAF KIF5B KIF5B ITPR3 ITPR3 RTN4 RTN4 ADAM17 ADAM17 MCU MCU G3VWL7_SARHA G3VWL7_SARHA CSNK2A1 CSNK2A1 EIF2AK3 EIF2AK3 NCSTN NCSTN G3VXD6_SARHA G3VXD6_SARHA TUBB6 TUBB6 TUBB3 TUBB3 LOC100913862 LOC100913862 WIPI2 WIPI2 LOC100919354 LOC100919354 DDIT3 DDIT3 NFKB1 NFKB1 LRP1 LRP1 INSR INSR TRAF2 TRAF2 FBXO21 FBXO21 KIF5A KIF5A MAPK1 MAPK1 SDHB SDHB TUBB TUBB WNT5A WNT5A PIK3R1 PIK3R1 LPL LPL TUBB4B TUBB4B NDUFA7 NDUFA7 NDUFS8 NDUFS8 DVL2 DVL2 IL1A IL1A PIK3R4 PIK3R4 CTNNB1 CTNNB1 CYBB CYBB GRIN2A GRIN2A RB1CC1 RB1CC1 ATG14 ATG14 NDUFA1 NDUFA1 NOS2 NOS2 IL1B IL1B RYR3 RYR3 AKT1 AKT1 PSMD13 PSMD13 NDUFA5 NDUFA5 COX6B1 COX6B1 WIPI1 WIPI1 APH1A APH1A CASP3 CASP3 MAP2K2 MAP2K2 BID BID NDUFAB1 NDUFAB1 G3W651_SARHA G3W651_SARHA FZD4 FZD4 WNT7B WNT7B PSENEN PSENEN GRIN1 GRIN1 GNAQ GNAQ PIK3R2 PIK3R2 NDUFS4 NDUFS4 EIF2S1 EIF2S1 PSEN2 PSEN2 WNT5B WNT5B G3W8I7_SARHA G3W8I7_SARHA WNT8A WNT8A WNT11 WNT11 AGER AGER BACE1 BACE1 WNT7A WNT7A XBP1 XBP1 MAPK3 MAPK3 ATP5PF ATP5PF RAF1 RAF1 IRS4 IRS4 APAF1 APAF1 GRIN2B GRIN2B IL6 IL6 G3WCX7_SARHA G3WCX7_SARHA NDUFA8 NDUFA8 UQCRC1 UQCRC1 CHRNA7 CHRNA7 NDUFB4 NDUFB4 COX7A2L COX7A2L VDAC2 VDAC2 KLC4 KLC4 TUBA8 TUBA8 ATP2A1 ATP2A1 PSMD6 PSMD6 PSEN1 PSEN1 WNT9A WNT9A ITPR1 ITPR1 NDUFA6 NDUFA6 ATG101 ATG101 MAP3K5 MAP3K5 BECN1 BECN1 UQCRQ UQCRQ ATP5F1E ATP5F1E FZD7 FZD7 TUBB1 TUBB1 NDUFC2 NDUFC2 PSMC5 PSMC5 APC2 APC2 FZD5 FZD5 ATP5PB ATP5PB LOC100932522 LOC100932522 SLC25A31 SLC25A31 DKK2 DKK2 TUBA4A TUBA4A ULK1 ULK1 PLCB2 PLCB2 NDUFA12 NDUFA12 NDUFB3 NDUFB3 PSMB5 PSMB5 WNT3A WNT3A ATP5MC1 ATP5MC1 NDUFS7 NDUFS7 COX4I2 COX4I2 LRP6 LRP6 NDUFB11 NDUFB11 PSMD4 PSMD4 ATF4 ATF4 PSMD3 PSMD3 ERN1 ERN1 TUBB2A TUBB2A COX6A2 COX6A2 WNT9B WNT9B CHRM3 CHRM3 IRS1 IRS1 PSMB4 PSMB4 WNT3 WNT3 GAPDH GAPDH WNT16 WNT16 DKK1 DKK1 WNT6 WNT6 CACNA1C CACNA1C NDUFB10 NDUFB10 NDUFB8 NDUFB8 PSMA7 PSMA7 KLC1 KLC1 PLCB1 PLCB1 PSMA1 PSMA1 LOC100920562 LOC100920562 AMBRA1 AMBRA1 PSMB1 PSMB1 NDUFB2 NDUFB2 COX5A COX5A PSMB7 PSMB7 PTGS2 PTGS2 CASP7 CASP7 WNT4 WNT4 ATG13 ATG13 PSMD14 PSMD14 PIK3CA PIK3CA CACNA1D CACNA1D NDUFS2 NDUFS2 LOC100919666 LOC100919666 LOC105749478 LOC105749478 FZD10 FZD10 SDHC SDHC PSMC1 PSMC1 PSMA8 PSMA8 WNT2B WNT2B ATP5F1A ATP5F1A WNT2 WNT2 NDUFB5 NDUFB5 PSMB3 PSMB3 COX5B COX5B FZD3 FZD3 APH1B APH1B PSMA4 PSMA4 NDUFS5 NDUFS5 VDAC1 VDAC1 MAPK8 MAPK8 NDUFS3 NDUFS3 NDUFS6 NDUFS6 IKBKB IKBKB GPR83 GPR83 NDUFS1 NDUFS1 VDAC3 VDAC3 PSMA3 PSMA3 ATP5F1C ATP5F1C PSMA5 PSMA5 IDE IDE SDHA SDHA G3X1Y7_SARHA G3X1Y7_SARHA FZD1 FZD1 PPP3CC PPP3CC CDK5R1 CDK5R1 PSMD11 PSMD11 ATP5PD ATP5PD ND1 ND1 MT-ND2 MT-ND2 COX1 COX1 COX2 COX2 ATP8 ATP8 ATP6 ATP6 COX3 COX3 MT-ND3 MT-ND3 ND4L ND4L MT-ND4 MT-ND4 MT-ND5 MT-ND5 ND6 ND6 CYTB CYTB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (231 aa)
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ATP5POUncharacterized protein. (213 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (378 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
NDUFB7Uncharacterized protein. (78 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
G3VDE6_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
FADDUncharacterized protein. (193 aa)
APCUncharacterized protein. (2704 aa)
G3VDR7_SARHAUncharacterized protein. (453 aa)
APOEUncharacterized protein. (256 aa)
ATP5MC3ATP synthase membrane subunit c locus 3; Belongs to the ATPase C chain family. (151 aa)
EIF2AK2Uncharacterized protein. (563 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (234 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (166 aa)
ATP5F1DATP-synt_DE_N domain-containing protein. (127 aa)
RTN3Reticulon. (959 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (524 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
APPAmyloid beta precursor protein. (750 aa)
LOC100921951Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
FZD2G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (235 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (374 aa)
G3VHY9_SARHACytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (72 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (530 aa)
CALML4Calmodulin like 4. (155 aa)
PSMB6Proteasome subunit beta. (239 aa)
NDUFA4L2NDUFA4 mitochondrial complex associated like 2. (87 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (249 aa)
FASUncharacterized protein. (283 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1010 aa)
NDUFA11Uncharacterized protein. (141 aa)
PPP3CASerine/threonine-protein phosphatase. (502 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (320 aa)
PPP3CBSerine/threonine-protein phosphatase. (501 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
AXIN1Axin 1. (875 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (442 aa)
CSF1Uncharacterized protein. (560 aa)
NAE1ThiF domain-containing protein. (284 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (377 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (718 aa)
NDUFA10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (347 aa)
NRBF2Nuclear receptor binding factor 2. (280 aa)
NOX4NADPH oxidase 4. (578 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (412 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
LOC100919671Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC100934740G_PROTEIN_RECEP_F1_2 domain-containing protein. (440 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
COX4I1Cytochrome c oxidase subunit 4I1. (178 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
PSMA2Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (233 aa)
AXIN2Axin 2. (837 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (437 aa)
ATP5MC2ATP synthase membrane subunit c locus 2; Belongs to the ATPase C chain family. (154 aa)
PSMD9PDZ domain-containing protein. (234 aa)
GRM5Glutamate metabotropic receptor 5. (878 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
CYC1Cytochrome c1. (285 aa)
PPP3R1Uncharacterized protein. (170 aa)
DVL3Uncharacterized protein. (272 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (627 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (928 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2665 aa)
RTN4Reticulon. (1023 aa)
ADAM17ADAM metallopeptidase domain 17. (791 aa)
MCUMitochondrial calcium uniporter. (312 aa)
G3VWL7_SARHACOX6C domain-containing protein. (76 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1081 aa)
NCSTNNicastrin. (680 aa)
G3VXD6_SARHATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (435 aa)
LOC100913862Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (411 aa)
LOC100919354Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (325 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (170 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
LRP1LDL receptor related protein 1. (3514 aa)
INSRFibronectin type-III domain-containing protein. (535 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
FBXO21F-box protein 21. (542 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (281 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (473 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
NDUFA7Uncharacterized protein. (115 aa)
NDUFS8NADH:ubiquinone oxidoreductase core subunit S8. (216 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (261 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1363 aa)
CTNNB1Catenin beta 1. (781 aa)
CYBBCytochrome b-245 beta chain. (471 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1333 aa)
RB1CC1RB1 inducible coiled-coil 1. (1592 aa)
ATG14Autophagy related 14. (511 aa)
NDUFA1Uncharacterized protein. (73 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
RYR3Ryanodine receptor 3. (4637 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (348 aa)
NDUFA5NADH:ubiquinone oxidoreductase subunit A5. (116 aa)
COX6B1Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (458 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (227 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (275 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (159 aa)
G3W651_SARHAUncharacterized protein; Belongs to the peptidase C14A family. (282 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
PSENENUncharacterized protein. (81 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (933 aa)
GNAQG protein subunit alpha q. (359 aa)
PIK3R2Uncharacterized protein. (738 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (216 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (462 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (448 aa)
G3W8I7_SARHATubulin domain-containing protein; Belongs to the tubulin family. (426 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
AGERAdvanced glycosylation end-product specific receptor. (407 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (503 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (293 aa)
XBP1BZIP domain-containing protein. (308 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (108 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
IRS4IRS-type PTB domain-containing protein. (870 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1255 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1118 aa)
IL6Uncharacterized protein. (212 aa)
G3WCX7_SARHAUncharacterized protein. (110 aa)
NDUFA8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (172 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (480 aa)
CHRNA7Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (385 aa)
NDUFB4Uncharacterized protein. (187 aa)
COX7A2LCytochrome c oxidase subunit 7A2 like. (132 aa)
VDAC2Voltage dependent anion channel 2. (293 aa)
KLC4Kinesin light chain 4. (610 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (355 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2696 aa)
NDUFA6NADH:ubiquinone oxidoreductase subunit A6; Belongs to the complex I LYR family. (138 aa)
ATG101Autophagy related 101. (218 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1385 aa)
BECN1Beclin 1. (448 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
ATP5F1EATP synthase F1 subunit epsilon. (51 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
NDUFC2NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (105 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
APC2APC regulator of WNT signaling pathway 2. (2196 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (260 aa)
LOC100932522Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (493 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (241 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (272 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1063 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NDUFA12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (119 aa)
NDUFB3NADH:ubiquinone oxidoreductase subunit B3. (101 aa)
PSMB5Proteasome subunit beta. (263 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (248 aa)
ATP5MC1ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (145 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (216 aa)
COX4I2Cytochrome c oxidase subunit 4I2. (179 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
NDUFB11NADH:ubiquinone oxidoreductase subunit B11. (152 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (379 aa)
ATF4Activating transcription factor 4. (344 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (470 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (922 aa)
TUBB2ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
COX6A2Cytochrome c oxidase subunit 6A, mitochondrial. (97 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (585 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
DKK1Uncharacterized protein. (138 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
NDUFB10NADH:ubiquinone oxidoreductase subunit B10. (176 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
PSMA7Proteasome subunit alpha type. (251 aa)
KLC1Uncharacterized protein. (633 aa)
PLCB1Phosphoinositide phospholipase C. (1041 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
LOC100920562Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1290 aa)
PSMB1Proteasome subunit beta. (244 aa)
NDUFB2NADH:ubiquinone oxidoreductase subunit B2. (102 aa)
COX5ACytochrome c oxidase subunit 5A. (117 aa)
PSMB7Proteasome subunit beta. (277 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (609 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (280 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (264 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (463 aa)
LOC100919666Uncharacterized protein. (430 aa)
LOC105749478Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (237 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (445 aa)
PSMA8Proteasome subunit alpha type. (257 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (149 aa)
PSMB3Proteasome subunit beta. (205 aa)
COX5BCytochrome c oxidase subunit 5B. (128 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (258 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
NDUFS5NADH:ubiquinone oxidoreductase subunit S5. (106 aa)
VDAC1Voltage dependent anion channel 1. (298 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (187 aa)
NDUFS6NADH:ubiquinone oxidoreductase subunit S6. (153 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
GPR83G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (424 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (741 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ATP5F1CATP synthase subunit gamma. (298 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (926 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (671 aa)
G3X1Y7_SARHAUncharacterized protein. (223 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (339 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (306 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (414 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
ND1NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (318 aa)
MT-ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (345 aa)
COX1Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (513 aa)
COX2Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (227 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (69 aa)
ATP6ATP synthase subunit a. (226 aa)
COX3Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (261 aa)
MT-ND3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (115 aa)
ND4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (98 aa)
MT-ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (459 aa)
MT-ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (605 aa)
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (166 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (381 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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