(50 nodes) Amphetamine addiction network (Sarcophilus harrisii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CALM1-2	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	CAMK2D	CaMKII_AD domain-containing protein. (87 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (852 aa)
	CALML4	Calmodulin like 4. (155 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (502 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (501 aa)
	MAOB	Amine oxidase. (438 aa)
	LOC100929360	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
	MAOA	Amine oxidase. (430 aa)
	PPP3R1	Uncharacterized protein. (170 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1333 aa)
	PPP1CB	Serine/threonine-protein phosphatase. (268 aa)
	PRKACA	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (933 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (465 aa)
	ATF6B	Activating transcription factor 6 beta. (709 aa)
	HDAC1	Hist_deacetyl domain-containing protein. (323 aa)
	SLC18A1	Solute carrier family 18 member A1. (524 aa)
	GRIN3A	Uncharacterized protein. (1055 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1118 aa)
	CREB3L2	BZIP domain-containing protein. (517 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (389 aa)
	CREB5	Uncharacterized protein. (109 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (473 aa)
	SIRT1	Sirtuin 1. (597 aa)
	PDYN	Prodynorphin. (258 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
	GNAS	Uncharacterized protein. (320 aa)
	GRIA4	ANF_receptor domain-containing protein. (433 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	ATF4	Activating transcription factor 4. (344 aa)
	CREB3	BZIP domain-containing protein. (370 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (892 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (641 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2069 aa)
	LOC100913731	Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (526 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
	DDC	Dopa decarboxylase. (485 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1211 aa)
	SLC18A2	Solute carrier family 18 member A2. (514 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
	ARC	Activity regulated cytoskeleton associated protein. (400 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (531 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARC	FOS	ENSSHAP00000020612	ENSSHAP00000020966	Activity regulated cytoskeleton associated protein.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.442
ARC	GRIN1	ENSSHAP00000020612	ENSSHAP00000011255	Activity regulated cytoskeleton associated protein.	Glutamate ionotropic receptor NMDA type subunit 1.	0.451
ARC	GRIN2B	ENSSHAP00000020612	ENSSHAP00000013154	Activity regulated cytoskeleton associated protein.	Glutamate ionotropic receptor NMDA type subunit 2B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.400
ATF2	ATF4	ENSSHAP00000012784	ENSSHAP00000016539	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 4.	0.940
ATF2	ATF6B	ENSSHAP00000012784	ENSSHAP00000011651	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 6 beta.	0.919
ATF2	CAMK2A	ENSSHAP00000012784	ENSSHAP00000020493	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.667
ATF2	CAMK2B	ENSSHAP00000012784	ENSSHAP00000017754	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Calcium/calmodulin dependent protein kinase II beta.	0.667
ATF2	CAMK2D	ENSSHAP00000012784	ENSSHAP00000002155	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	CaMKII_AD domain-containing protein.	0.667
ATF2	CREB1	ENSSHAP00000012784	ENSSHAP00000016341	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 1.	0.962
ATF2	CREB3	ENSSHAP00000012784	ENSSHAP00000016802	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	BZIP domain-containing protein.	0.914
ATF2	CREB3L1	ENSSHAP00000012784	ENSSHAP00000017941	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 1.	0.901
ATF2	CREB3L2	ENSSHAP00000012784	ENSSHAP00000013552	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	BZIP domain-containing protein.	0.901
ATF2	CREB3L3	ENSSHAP00000012784	ENSSHAP00000011486	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 3.	0.903
ATF2	CREB3L4	ENSSHAP00000012784	ENSSHAP00000013752	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 4.	0.903
ATF2	CREB5	ENSSHAP00000012784	ENSSHAP00000014383	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Uncharacterized protein.	0.900
ATF2	FOS	ENSSHAP00000012784	ENSSHAP00000020966	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.859
ATF2	LOC100913731	ENSSHAP00000012784	ENSSHAP00000017911	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.698
ATF2	LOC100929360	ENSSHAP00000012784	ENSSHAP00000005646	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.698
ATF2	PPP1CA	ENSSHAP00000012784	ENSSHAP00000006328	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.695
ATF2	PPP1CB	ENSSHAP00000012784	ENSSHAP00000010458	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Serine/threonine-protein phosphatase.	0.685