(43 nodes) Legionellosis network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ITGAM	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (785 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
	PYDC1	Pyrin domain containing 1. (89 aa)
	EEF1G	Uncharacterized protein. (326 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (321 aa)
	RAB1A	RAB1A, member RAS oncogene family. (221 aa)
	PYCARD	Uncharacterized protein. (200 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	EEF1A1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
	LOC100919671	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (653 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (980 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (783 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (652 aa)
	SAR1A	Secretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	BCL2L13	BCL2 like 13. (475 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
	CASP3	Uncharacterized protein; Belongs to the peptidase C14A family. (275 aa)
	G3W651_SARHA	Uncharacterized protein; Belongs to the peptidase C14A family. (282 aa)
	LOC100931131	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	RAB1B	RAB1B, member RAS oncogene family. (201 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1255 aa)
	IL6	Uncharacterized protein. (212 aa)
	G3WE02_SARHA	Uncharacterized protein. (212 aa)
	G3WEP2_SARHA	Uncharacterized protein. (212 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	IL18	Uncharacterized protein. (201 aa)
	CLK1	CDC like kinase 1; Belongs to the protein kinase superfamily. (485 aa)
	HBS1L	HBS1 like translational GTPase. (685 aa)
	ARF1	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	SAR1B	Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (280 aa)
	G3WUN3_SARHA	C-X-C motif chemokine. (117 aa)
	CD14	Uncharacterized protein. (378 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (191 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (802 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (828 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
	EEF1A2	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	CASP3	ENSSHAP00000013128	ENSSHAP00000010635	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.978
APAF1	CASP7	ENSSHAP00000013128	ENSSHAP00000019102	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.822
APAF1	CASP8	ENSSHAP00000013128	ENSSHAP00000000850	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.770
APAF1	EEF1G	ENSSHAP00000013128	ENSSHAP00000003451	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.476
APAF1	G3W651_SARHA	ENSSHAP00000013128	ENSSHAP00000010906	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.978
APAF1	HBS1L	ENSSHAP00000013128	ENSSHAP00000015857	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HBS1 like translational GTPase.	0.584
APAF1	LOC100919671	ENSSHAP00000013128	ENSSHAP00000006074	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
ARF1	LOC100931131	ENSSHAP00000017177	ENSSHAP00000011160	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.901
ARF1	RAB1A	ENSSHAP00000017177	ENSSHAP00000004079	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	RAB1A, member RAS oncogene family.	0.413
ARF1	RAB1B	ENSSHAP00000017177	ENSSHAP00000012108	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	RAB1B, member RAS oncogene family.	0.413
ARF1	SEC22B	ENSSHAP00000017177	ENSSHAP00000019572	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family.	0.479
CASP3	APAF1	ENSSHAP00000010635	ENSSHAP00000013128	Uncharacterized protein; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.978
CASP3	CASP7	ENSSHAP00000010635	ENSSHAP00000019102	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.952
CASP3	CASP8	ENSSHAP00000010635	ENSSHAP00000000850	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.972
CASP3	G3W651_SARHA	ENSSHAP00000010635	ENSSHAP00000010906	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.900
CASP3	IL1B	ENSSHAP00000010635	ENSSHAP00000010316	Uncharacterized protein; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.550
CASP3	IL6	ENSSHAP00000010635	ENSSHAP00000013156	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.519
CASP3	LOC100919671	ENSSHAP00000010635	ENSSHAP00000006074	Uncharacterized protein; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.968
CASP3	NFKB1	ENSSHAP00000010635	ENSSHAP00000008514	Uncharacterized protein; Belongs to the peptidase C14A family.	Nuclear factor kappa B subunit 1.	0.412
CASP7	APAF1	ENSSHAP00000019102	ENSSHAP00000013128	Caspase 7; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.822