STRINGSTRING
CHUK CHUK PXN PXN PIK3CB PIK3CB G3VBY6_SARHA G3VBY6_SARHA ARF6 ARF6 CRKL CRKL PTK2B PTK2B MAP2K7 MAP2K7 MAPK10 MAPK10 IL2 IL2 PYDC1 PYDC1 G3VJ96_SARHA G3VJ96_SARHA NFKBIA NFKBIA PYCARD PYCARD G3VMC7_SARHA G3VMC7_SARHA BAIAP2 BAIAP2 TNF TNF ZAP70 ZAP70 VAV1 VAV1 PKN1 PKN1 WASF2 WASF2 WIPF1 WIPF1 PIP5K1B PIP5K1B MAPK9 MAPK9 MAPK13 MAPK13 TBK1 TBK1 RPS6KA2 RPS6KA2 NFKB1 NFKB1 IRAK1 IRAK1 TRAF2 TRAF2 MAPK1 MAPK1 PIK3R1 PIK3R1 TICAM1 TICAM1 LCK LCK IL1B IL1B AKT1 AKT1 NFATC1 NFATC1 MAP2K2 MAP2K2 FN1 FN1 GNAQ GNAQ PIK3R2 PIK3R2 ELMO2 ELMO2 FYB1 FYB1 LOC100925648 LOC100925648 RHOG RHOG NFATC3 NFATC3 RPS6KA3 RPS6KA3 VAV2 VAV2 MAPK3 MAPK3 PTK2 PTK2 ITGA5 ITGA5 IL6 IL6 CD8B CD8B G3WE02_SARHA G3WE02_SARHA G3WEP2_SARHA G3WEP2_SARHA MYD88 MYD88 RPS6KA1 RPS6KA1 IL18 IL18 ACTB ACTB WIPF2 WIPF2 RPS6KA6 RPS6KA6 G3WKU6_SARHA G3WKU6_SARHA TRAF6 TRAF6 PIP5K1A PIP5K1A ITGA4 ITGA4 VAV3 VAV3 MAP2K3 MAP2K3 ROCK1 ROCK1 ARHGEF28 ARHGEF28 IRAK4 IRAK4 G3WNV5_SARHA G3WNV5_SARHA TAB1 TAB1 ACTR3B ACTR3B RAC2 RAC2 CD4 CD4 CXCL8 CXCL8 RHOA RHOA ITGB1 ITGB1 PIK3CA PIK3CA TAB2 TAB2 SKAP2 SKAP2 TLR4 TLR4 SRC SRC MAPK8 MAPK8 LOC100914443 LOC100914443 MAP3K7 MAP3K7 FOS FOS IKBKB IKBKB ARHGEF12 ARHGEF12 IL10 IL10 NFATC2 NFATC2 LCP2 LCP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (295 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
G3VBY6_SARHAIg-like domain-containing protein. (121 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (187 aa)
CRKLCRK like proto-oncogene, adaptor protein. (194 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1012 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (524 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (141 aa)
PYDC1Pyrin domain containing 1. (89 aa)
G3VJ96_SARHAIg-like domain-containing protein. (282 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
PYCARDUncharacterized protein. (200 aa)
G3VMC7_SARHAIRF-3 domain-containing protein. (289 aa)
BAIAP2BAI1 associated protein 2. (503 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
ZAP70Zeta chain of T cell receptor associated protein kinase 70. (648 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
PKN1Protein kinase N1. (937 aa)
WASF2WASP family member 2. (498 aa)
WIPF1WAS/WASL interacting protein family member 1. (506 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (431 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
TBK1TANK binding kinase 1. (732 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (654 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (690 aa)
LCKTyrosine-protein kinase. (509 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
FN1Fibronectin 1. (2302 aa)
GNAQG protein subunit alpha q. (359 aa)
PIK3R2Uncharacterized protein. (738 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
FYB1FYN binding protein 1. (842 aa)
LOC100925648Uncharacterized protein. (201 aa)
RHOGRas homolog family member G. (191 aa)
NFATC3Nuclear factor of activated T cells 3. (1052 aa)
RPS6KA3Ribosomal protein S6 kinase. (745 aa)
VAV2Vav guanine nucleotide exchange factor 2. (699 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1061 aa)
IL6Uncharacterized protein. (212 aa)
CD8BIg-like domain-containing protein. (214 aa)
G3WE02_SARHAUncharacterized protein. (212 aa)
G3WEP2_SARHAUncharacterized protein. (212 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (660 aa)
IL18Uncharacterized protein. (201 aa)
ACTBActin beta. (375 aa)
WIPF2WAS/WASL interacting protein family member 2. (442 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (709 aa)
G3WKU6_SARHAC-C motif chemokine. (143 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (547 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
VAV3Vav guanine nucleotide exchange factor 3. (846 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (337 aa)
ROCK1Uncharacterized protein. (516 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1532 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
G3WNV5_SARHAIg-like domain-containing protein. (124 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (536 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (407 aa)
RAC2Rac family small GTPase 2. (192 aa)
CD4Uncharacterized protein. (485 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
RHOAUncharacterized protein. (193 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (799 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (694 aa)
SKAP2Src kinase associated phosphoprotein 2. (347 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (828 aa)
SRCTyrosine-protein kinase. (533 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
LOC100914443Uncharacterized protein. (187 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1542 aa)
IL10Uncharacterized protein. (176 aa)
NFATC2Nuclear factor of activated T cells 2. (703 aa)
LCP2Lymphocyte cytosolic protein 2. (515 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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