STRINGSTRING
IFNGR1 IFNGR1 ITGAM ITGAM G3VBY6_SARHA G3VBY6_SARHA G3VCF6_SARHA G3VCF6_SARHA G3VGC7_SARHA G3VGC7_SARHA FCGR3B FCGR3B G3VJ96_SARHA G3VJ96_SARHA NFKBIA NFKBIA HLA-DRA HLA-DRA G3VM66_SARHA G3VM66_SARHA HLA-DMA HLA-DMA TNF TNF EEF1A1 EEF1A1 G3VR65_SARHA G3VR65_SARHA MAPK13 MAPK13 CYBA CYBA TGFB1 TGFB1 NFKB1 NFKB1 TLR2 TLR2 IRAK1 IRAK1 MAPK1 MAPK1 IL1A IL1A CYBB CYBB PRKCB PRKCB NOS2 NOS2 IL1B IL1B MAPK3 MAPK3 IL4 IL4 MYD88 MYD88 NCF4 NCF4 NCF2 NCF2 TRAF6 TRAF6 ITGA4 ITGA4 JAK1 JAK1 IRAK4 IRAK4 G3WNV5_SARHA G3WNV5_SARHA TAB1 TAB1 JAK2 JAK2 IFNG IFNG PTGS2 PTGS2 PTPN6 PTPN6 ITGB1 ITGB1 TAB2 TAB2 STAT1 STAT1 TLR4 TLR4 TGFB2 TGFB2 MAP3K7 MAP3K7 FOS FOS IL10 IL10 EEF1A2 EEF1A2 IL12B IL12B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGR1Uncharacterized protein. (189 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (785 aa)
G3VBY6_SARHAIg-like domain-containing protein. (121 aa)
G3VCF6_SARHAIg-like domain-containing protein. (143 aa)
G3VGC7_SARHAIg-like domain-containing protein. (235 aa)
FCGR3BIg-like domain-containing protein. (256 aa)
G3VJ96_SARHAIg-like domain-containing protein. (282 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (262 aa)
G3VM66_SARHAIg-like domain-containing protein. (268 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha. (265 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
G3VR65_SARHAIg-like domain-containing protein. (259 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CYBACytochrome b-245 alpha chain. (209 aa)
TGFB1TGF_BETA_2 domain-containing protein. (162 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (783 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (654 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (261 aa)
CYBBCytochrome b-245 beta chain. (471 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
IL4Uncharacterized protein. (156 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
NCF4Neutrophil cytosolic factor 4. (340 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
G3WNV5_SARHAIg-like domain-containing protein. (124 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (536 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (609 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (799 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (694 aa)
STAT1Signal transducer and activator of transcription. (762 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (828 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
IL10Uncharacterized protein. (176 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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