STRINGSTRING
CHUK CHUK PIK3CB PIK3CB G3VAP8_SARHA G3VAP8_SARHA PPP2R1A PPP2R1A STAT2 STAT2 G3VBX3_SARHA G3VBX3_SARHA CASP8 CASP8 LOC100928324 LOC100928324 IFNAR1 IFNAR1 G3VDA6_SARHA G3VDA6_SARHA LOC100920968 LOC100920968 FADD FADD YWHAH YWHAH LOC100926881 LOC100926881 EIF2AK2 EIF2AK2 EGF EGF SCARB1 SCARB1 LOC100922240 LOC100922240 PPARA PPARA CD81 CD81 NFKBIA NFKBIA CCND1 CCND1 FAS FAS CDK6 CDK6 CLDN16 CLDN16 SOS2 SOS2 LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA G3VMC7_SARHA G3VMC7_SARHA TNF TNF CLDN18 CLDN18 CLDN2 CLDN2 BAK1 BAK1 YWHAQ YWHAQ LOC100919671 LOC100919671 ARAF ARAF TBK1 TBK1 EIF2AK3 EIF2AK3 CLDN14 CLDN14 NFKB1 NFKB1 TRAF2 TRAF2 TYK2 TYK2 MAPK1 MAPK1 CDK2 CDK2 CLDN7 CLDN7 PIK3R1 PIK3R1 CTNNB1 CTNNB1 TICAM1 TICAM1 AKT1 AKT1 RSAD2 RSAD2 CASP3 CASP3 TRAF3 TRAF3 MAP2K2 MAP2K2 BID BID CDK4 CDK4 G3W651_SARHA G3W651_SARHA LDLR LDLR PIK3R2 PIK3R2 EIF2S1 EIF2S1 PPP2R2A PPP2R2A EIF2AK4 EIF2AK4 PPP2R2B PPP2R2B MAPK3 MAPK3 RAF1 RAF1 APAF1 APAF1 YWHAB YWHAB CDKN1A CDKN1A YWHAZ YWHAZ CLDN17 CLDN17 CLDN25 CLDN25 EIF3E EIF3E EIF2AK1 EIF2AK1 LOC100923805 LOC100923805 LOC100926163 LOC100926163 CFLAR CFLAR TRAF6 TRAF6 CLDN10 CLDN10 RB1 RB1 PPP2R1B PPP2R1B JAK1 JAK1 RIPK1 RIPK1 CLDN11 CLDN11 YWHAE YWHAE G3WP59_SARHA G3WP59_SARHA CLDN19 CLDN19 SOS1 SOS1 STAT3 STAT3 IFNG IFNG CLDN23 CLDN23 TP53 TP53 RXRA RXRA E2F3 E2F3 G3WUJ4_SARHA G3WUJ4_SARHA LOC100928264 LOC100928264 PIK3CA PIK3CA PPP2CA PPP2CA CLDN34 CLDN34 PPP2R2C PPP2R2C STAT1 STAT1 NR1H3 NR1H3 OCLN OCLN CLDN6 CLDN6 CLDN9 CLDN9 IKBKE IKBKE LOC100914443 LOC100914443 LOC105749577 LOC105749577 LOC100914703 LOC100914703 LOC100914965 LOC100914965 IKBKB IKBKB SOCS3 SOCS3 G3X039_SARHA G3X039_SARHA GRB2 GRB2 FASLG FASLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
G3VAP8_SARHAMARVEL domain-containing protein. (353 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (490 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
G3VBX3_SARHASCY domain-containing protein. (94 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
LOC100928324SP-RING-type domain-containing protein. (342 aa)
IFNAR1Uncharacterized protein. (570 aa)
G3VDA6_SARHAUncharacterized protein. (73 aa)
LOC100920968Uncharacterized protein. (186 aa)
FADDUncharacterized protein. (193 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (226 aa)
LOC100926881Uncharacterized protein. (485 aa)
EIF2AK2Uncharacterized protein. (563 aa)
EGFEpidermal growth factor. (1129 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (545 aa)
LOC100922240SCY domain-containing protein. (105 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
CD81Tetraspanin. (214 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
FASUncharacterized protein. (283 aa)
CDK6Cyclin dependent kinase 6. (202 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1329 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
G3VMC7_SARHAIRF-3 domain-containing protein. (289 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (253 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (244 aa)
LOC100919671Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (627 aa)
TBK1TANK binding kinase 1. (732 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1081 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
TYK2Tyrosine-protein kinase. (1197 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CTNNB1Catenin beta 1. (781 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (690 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (362 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (275 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
G3W651_SARHAUncharacterized protein; Belongs to the peptidase C14A family. (282 aa)
LDLRLow density lipoprotein receptor. (865 aa)
PIK3R2Uncharacterized protein. (738 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (444 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1598 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1255 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (232 aa)
CLDN25Claudin 25. (214 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (634 aa)
LOC100923805Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
LOC100926163Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (496 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
RB1RB transcriptional corepressor 1. (848 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (540 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (716 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
G3WP59_SARHAClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (184 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (277 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
RXRARetinoid X receptor alpha. (483 aa)
E2F3E2F transcription factor 3. (337 aa)
G3WUJ4_SARHA25A_SYNTH_3 domain-containing protein. (96 aa)
LOC10092826425A_SYNTH_3 domain-containing protein. (368 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PPP2CASerine/threonine-protein phosphatase. (333 aa)
CLDN34Uncharacterized protein. (234 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
STAT1Signal transducer and activator of transcription. (762 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (422 aa)
OCLNMARVEL domain-containing protein. (465 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (727 aa)
LOC100914443Uncharacterized protein. (187 aa)
LOC10574957725A_SYNTH_3 domain-containing protein. (401 aa)
LOC100914703Uncharacterized protein. (192 aa)
LOC100914965Uncharacterized protein. (183 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
SOCS3Suppressor of cytokine signaling 3. (228 aa)
G3X039_SARHASerine/threonine-protein phosphatase. (322 aa)
GRB2Growth factor receptor bound protein 2. (191 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (270 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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