STRINGSTRING
CHUK CHUK PIK3CB PIK3CB LOC111720510 LOC111720510 TRRAP-2 TRRAP-2 G3VCF6_SARHA G3VCF6_SARHA SLC25A4 SLC25A4 CCNA2 CCNA2 KAT5 KAT5 CDC20 CDC20 G3VGC5_SARHA G3VGC5_SARHA G3VGC7_SARHA G3VGC7_SARHA MAPK10 MAPK10 IL2 IL2 LOC105749194 LOC105749194 FOSL1 FOSL1 IL1R2 IL1R2 G3VHW5_SARHA G3VHW5_SARHA ADCY2 ADCY2 TSPO TSPO G3VJJ0_SARHA G3VJJ0_SARHA NFKBIA NFKBIA G3VK11_SARHA G3VK11_SARHA CCND1 CCND1 HLA-DRA HLA-DRA PPP3CA PPP3CA G3VKW1_SARHA G3VKW1_SARHA ANAPC4 ANAPC4 RELB RELB IL2RG IL2RG PPP3CB PPP3CB PTEN PTEN G3VM66_SARHA G3VM66_SARHA LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA HLA-DMA HLA-DMA STAT5B STAT5B CCNA1 CCNA1 G3VML6_SARHA G3VML6_SARHA LTA LTA TNF TNF LOC105749196 LOC105749196 CCND3 CCND3 ESPL1 ESPL1 LOC100929360 LOC100929360 G3VR65_SARHA G3VR65_SARHA JAK3 JAK3 MAPK9 MAPK9 IL1R1 IL1R1 NFYB NFYB TBPL1 TBPL1 VAC14 VAC14 KAT2A KAT2A ADCY3 ADCY3 PPP3R1 PPP3R1 TGFB1 TGFB1 ADCY4 ADCY4 LOC105749124 LOC105749124 EP300 EP300 G3VXF2_SARHA G3VXF2_SARHA NFATC4 NFATC4 RANBP1 RANBP1 GPS2 GPS2 ETS2 ETS2 ITGAL ITGAL ADCY6 ADCY6 NFKB1 NFKB1 MAPK1 MAPK1 CRTC3 CRTC3 CDK2 CDK2 PIK3R1 PIK3R1 KAT2B KAT2B LOC100933797 LOC100933797 MAD2L1 MAD2L1 LCK LCK ADCY1 ADCY1 AKT1 AKT1 FDPS FDPS NFATC1 NFATC1 ZFP36 ZFP36 CRTC1 CRTC1 TBPL2 TBPL2 PRKACA PRKACA MAP2K2 MAP2K2 ANAPC2 ANAPC2 CDK4 CDK4 CCND2 CCND2 MSX2 MSX2 LOC100924279 LOC100924279 PIK3R2 PIK3R2 ANAPC10 ANAPC10 CREB3L3 CREB3L3 ATF6B ATF6B CDC16 CDC16 CHEK2 CHEK2 NFATC3 NFATC3 PTTG1 PTTG1 SMAD4 SMAD4 BUB3 BUB3 SAHAI-12 SAHAI-12 ATM ATM CDC23 CDC23 IL2RA IL2RA MAPK3 MAPK3 ATF2 ATF2 MAP3K1 MAP3K1 XPO1 XPO1 IL6 IL6 CANX CANX CDKN1A CDKN1A CREB3L2 CREB3L2 CRTC2 CRTC2 MAP3K14 MAP3K14 CREB3L4 CREB3L4 MSX1 MSX1 MAP3K3 MAP3K3 VDAC2 VDAC2 CREB5 CREB5 EGR1 EGR1 TGFBR2 TGFBR2 ADCY9 ADCY9 SRF SRF MMP7 MMP7 SMAD2 SMAD2 SLC25A31 SLC25A31 CD3G CD3G CD3D CD3D BCL2L1 BCL2L1 TCF3 TCF3 CREBBP CREBBP CREB1 CREB1 RB1 RB1 ATF4 ATF4 CREB3 CREB3 TLN1 TLN1 JAK1 JAK1 LTBR LTBR IL2RB IL2RB MAD1L1 MAD1L1 ANAPC1 ANAPC1 CCNB2 CCNB2 ANAPC7 ANAPC7 CALR CALR SLC2A1 SLC2A1 NRP1 NRP1 LOC100913731 LOC100913731 CREB3L1 CREB3L1 TP53 TP53 ELK4 ELK4 E2F3 E2F3 TBP TBP TLN2 TLN2 CD4 CD4 ATR ATR CCNE1 CCNE1 XIAP XIAP PIK3CA PIK3CA IL15 IL15 ANAPC5 ANAPC5 TGFBR1 TGFBR1 SPI1 SPI1 CHEK1 CHEK1 ETS1 ETS1 VDAC1 VDAC1 MAPK8 MAPK8 TGFB2 TGFB2 CDC26 CDC26 TSPO2 TSPO2 FOS FOS IKBKB IKBKB CCNE2 CCNE2 POLB POLB VDAC3 VDAC3 RAN RAN NFATC2 NFATC2 PPP3CC PPP3CC ADCY7 ADCY7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
LOC111720510STAT_bind domain-containing protein. (112 aa)
TRRAP-2Uncharacterized protein. (267 aa)
G3VCF6_SARHAIg-like domain-containing protein. (143 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (363 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (481 aa)
CDC20Cell division cycle 20. (499 aa)
G3VGC5_SARHAIg-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
G3VGC7_SARHAIg-like domain-containing protein. (235 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (141 aa)
LOC105749194Ig-like domain-containing protein. (341 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (174 aa)
IL1R2Uncharacterized protein. (424 aa)
G3VHW5_SARHAHomeobox domain-containing protein. (127 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (850 aa)
TSPOTranslocator protein. (168 aa)
G3VJJ0_SARHAIg-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
G3VK11_SARHAIg-like domain-containing protein. (244 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (262 aa)
PPP3CASerine/threonine-protein phosphatase. (502 aa)
G3VKW1_SARHAHomeobox domain-containing protein. (162 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (768 aa)
RELBRELB proto-oncogene, NF-kB subunit. (416 aa)
IL2RGFibronectin type-III domain-containing protein. (387 aa)
PPP3CBSerine/threonine-protein phosphatase. (501 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
G3VM66_SARHAIg-like domain-containing protein. (268 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha. (265 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (469 aa)
G3VML6_SARHAIg-like domain-containing protein. (270 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (201 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
LOC105749196Ig-like domain-containing protein. (285 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (234 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2114 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
G3VR65_SARHAIg-like domain-containing protein. (259 aa)
JAK3Tyrosine-protein kinase. (1110 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
IL1R1Interleukin 1 receptor type 1. (570 aa)
NFYBNuclear transcription factor Y subunit beta. (210 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
VAC14Uncharacterized protein. (778 aa)
KAT2ALysine acetyltransferase 2A. (725 aa)
ADCY3Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (870 aa)
PPP3R1Uncharacterized protein. (170 aa)
TGFB1TGF_BETA_2 domain-containing protein. (162 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
LOC105749124Ig-like domain-containing protein. (351 aa)
EP300E1A binding protein p300. (1895 aa)
G3VXF2_SARHACalreticulin. (419 aa)
NFATC4Nuclear factor of activated T cells 4. (875 aa)
RANBP1RanBD1 domain-containing protein. (174 aa)
GPS2G protein pathway suppressor 2. (326 aa)
ETS2ETS proto-oncogene 2, transcription factor; Transcription factor; Belongs to the ETS family. (476 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1258 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
CRTC3CREB regulated transcription coactivator 3. (543 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
KAT2BLysine acetyltransferase 2B. (710 aa)
LOC100933797Uncharacterized protein. (463 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
LCKTyrosine-protein kinase. (509 aa)
ADCY1AC_N domain-containing protein. (214 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FDPSUncharacterized protein; Belongs to the FPP/GGPP synthase family. (420 aa)
NFATC1Nuclear factor of activated T cells 1. (950 aa)
ZFP36Uncharacterized protein. (283 aa)
CRTC1CREB regulated transcription coactivator 1. (503 aa)
TBPL2Uncharacterized protein. (183 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (786 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
CCND2CYCLIN domain-containing protein; Belongs to the cyclin family. (141 aa)
MSX2Msh homeobox 2. (275 aa)
LOC100924279Uncharacterized protein. (172 aa)
PIK3R2Uncharacterized protein. (738 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
ATF6BActivating transcription factor 6 beta. (709 aa)
CDC16Cell division cycle 16. (623 aa)
CHEK2Checkpoint kinase 2. (519 aa)
NFATC3Nuclear factor of activated T cells 3. (1052 aa)
PTTG1Uncharacterized protein. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
SAHAI-12Ig-like domain-containing protein; Belongs to the MHC class I family. (364 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3068 aa)
CDC23Cell division cycle 23. (595 aa)
IL2RAUncharacterized protein. (291 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1340 aa)
XPO1Exportin 1. (1071 aa)
IL6Uncharacterized protein. (212 aa)
CANXCalnexin. (601 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
CREB3L2BZIP domain-containing protein. (517 aa)
CRTC2CREB regulated transcription coactivator 2. (634 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (933 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (389 aa)
MSX1Msh homeobox 1. (257 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
VDAC2Voltage dependent anion channel 2. (293 aa)
CREB5Uncharacterized protein. (109 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (528 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (409 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1358 aa)
SRFSerum response factor. (306 aa)
MMP7ZnMc domain-containing protein. (264 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (241 aa)
CD3GCD3g molecule. (188 aa)
CD3DIg_4 domain-containing protein. (189 aa)
BCL2L1BCL2 like 1. (227 aa)
TCF3Transcription factor 3. (633 aa)
CREBBPCREB binding protein. (2452 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
RB1RB transcriptional corepressor 1. (848 aa)
ATF4Activating transcription factor 4. (344 aa)
CREB3BZIP domain-containing protein. (370 aa)
TLN1Talin 1. (2547 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
LTBRLymphotoxin beta receptor. (419 aa)
IL2RBFibronectin type-III domain-containing protein. (556 aa)
MAD1L1Uncharacterized protein. (471 aa)
ANAPC1Anaphase promoting complex subunit 1. (1949 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
CALRCalreticulin. (418 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (857 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
ELK4ETS transcription factor ELK4. (437 aa)
E2F3E2F transcription factor 3. (337 aa)
TBPTATA-box binding protein. (308 aa)
TLN2I/LWEQ domain-containing protein. (2229 aa)
CD4Uncharacterized protein. (485 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2566 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (423 aa)
XIAPX-linked inhibitor of apoptosis. (492 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (184 aa)
ANAPC5Anaphase promoting complex subunit 5. (672 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (475 aa)
SPI1Spi-1 proto-oncogene. (289 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
ETS1ETS proto-oncogene 1, transcription factor. (442 aa)
VDAC1Voltage dependent anion channel 1. (298 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
CDC26Cell division cycle 26. (85 aa)
TSPO2Translocator protein 2. (177 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
NFATC2Nuclear factor of activated T cells 2. (703 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1116 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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