STRINGSTRING
CHUK CHUK PIK3CB PIK3CB PSMD8 PSMD8 STAT2 STAT2 ENTPD3 ENTPD3 G3VBX3_SARHA G3VBX3_SARHA G3VBY6_SARHA G3VBY6_SARHA PSMD7 PSMD7 CASP8 CASP8 G3VCF6_SARHA G3VCF6_SARHA IFNAR1 IFNAR1 G3VDA6_SARHA G3VDA6_SARHA LOC100920968 LOC100920968 TAP2 TAP2 SIN3A SIN3A FADD FADD EIF2AK2 EIF2AK2 SYK SYK CCNA2 CCNA2 G3VGC5_SARHA G3VGC5_SARHA G3VGC7_SARHA G3VGC7_SARHA MAP2K7 MAP2K7 MAPK10 MAPK10 LOC105749194 LOC105749194 PSMC4 PSMC4 LOC100922240 LOC100922240 LOC100932860 LOC100932860 G3VJ96_SARHA G3VJ96_SARHA G3VJJ0_SARHA G3VJJ0_SARHA NFKBIA NFKBIA G3VK11_SARHA G3VK11_SARHA CCND1 CCND1 FAS FAS HLA-DRA HLA-DRA RBPJ RBPJ CDK6 CDK6 RELB RELB G3VM66_SARHA G3VM66_SARHA G3VMC7_SARHA G3VMC7_SARHA HLA-DMA HLA-DMA CCNA1 CCNA1 G3VML6_SARHA G3VML6_SARHA TNF TNF PSMC2 PSMC2 GADD45G GADD45G LOC105749196 LOC105749196 SKP2 SKP2 CCND3 CCND3 PSMD1 PSMD1 G3VR65_SARHA G3VR65_SARHA JAK3 JAK3 BAK1 BAK1 LOC100919671 LOC100919671 MAPK9 MAPK9 NCOR2 NCOR2 MAPK13 MAPK13 BLNK BLNK TBK1 TBK1 LOC105749124 LOC105749124 G3VXF2_SARHA G3VXF2_SARHA POLK POLK ITGAL ITGAL TAPBP TAPBP NFKB1 NFKB1 TLR2 TLR2 IRAK1 IRAK1 LOC100927399 LOC100927399 TRAF2 TRAF2 TYK2 TYK2 CDK2 CDK2 PIK3R1 PIK3R1 GADD45B GADD45B LOC100933797 LOC100933797 SAP30L SAP30L AKT1 AKT1 PSMD13 PSMD13 CASP3 CASP3 TRAF3 TRAF3 BID BID CDK4 CDK4 G3W651_SARHA G3W651_SARHA CCND2 CCND2 PIK3R2 PIK3R2 ENTPD1 ENTPD1 HDAC1 HDAC1 BCL2L11 BCL2L11 MDM2 MDM2 TNFAIP3 TNFAIP3 SAHAI-12 SAHAI-12 APAF1 APAF1 IL6 IL6 CDKN1B CDKN1B CDKN1A CDKN1A PLCG2 PLCG2 LYN LYN MAP3K14 MAP3K14 ENTPD8 ENTPD8 USP7 USP7 SAP30 SAP30 LOC100932670 LOC100932670 MYD88 MYD88 HDAC2 HDAC2 PSMD6 PSMD6 CD19 CD19 RUNX3 RUNX3 PSMC5 PSMC5 RBPJL RBPJL CD3G CD3G CD3D CD3D BTK BTK TRAF6 TRAF6 RB1 RB1 PSMD4 PSMD4 PSMD3 PSMD3 TRAF5 TRAF5 JAK1 JAK1 MAP2K3 MAP2K3 RIPK1 RIPK1 IRAK4 IRAK4 PDIA3 PDIA3 G3WNV5_SARHA G3WNV5_SARHA TAB1 TAB1 VIM VIM STAT3 STAT3 CALR CALR TP53 TP53 CIR1 CIR1 E2F3 E2F3 G3WUJ4_SARHA G3WUJ4_SARHA CCNE1 CCNE1 LOC100928264 LOC100928264 PSMD14 PSMD14 PIK3CA PIK3CA TAB2 TAB2 PSMC1 PSMC1 STAT1 STAT1 DDB2 DDB2 CD58 CD58 IKBKE IKBKE MAPK8 MAPK8 LOC100914443 LOC100914443 LOC105749577 LOC105749577 MAP3K7 MAP3K7 LOC100914703 LOC100914703 LOC100914965 LOC100914965 BCL2 BCL2 IKBKB IKBKB CCNE2 CCNE2 PSMD11 PSMD11 CD247 CD247
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (231 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (434 aa)
G3VBX3_SARHASCY domain-containing protein. (94 aa)
G3VBY6_SARHAIg-like domain-containing protein. (121 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (378 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
G3VCF6_SARHAIg-like domain-containing protein. (143 aa)
IFNAR1Uncharacterized protein. (570 aa)
G3VDA6_SARHAUncharacterized protein. (73 aa)
LOC100920968Uncharacterized protein. (186 aa)
TAP2Uncharacterized protein. (708 aa)
SIN3ASIN3 transcription regulator family member A. (1275 aa)
FADDUncharacterized protein. (193 aa)
EIF2AK2Uncharacterized protein. (563 aa)
SYKTyrosine-protein kinase. (466 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (363 aa)
G3VGC5_SARHAIg-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
G3VGC7_SARHAIg-like domain-containing protein. (235 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (524 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC105749194Ig-like domain-containing protein. (341 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (374 aa)
LOC100922240SCY domain-containing protein. (105 aa)
LOC100932860SKIP_SNW domain-containing protein. (536 aa)
G3VJ96_SARHAIg-like domain-containing protein. (282 aa)
G3VJJ0_SARHAIg-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
G3VK11_SARHAIg-like domain-containing protein. (244 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
FASUncharacterized protein. (283 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (262 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (465 aa)
CDK6Cyclin dependent kinase 6. (202 aa)
RELBRELB proto-oncogene, NF-kB subunit. (416 aa)
G3VM66_SARHAIg-like domain-containing protein. (268 aa)
G3VMC7_SARHAIRF-3 domain-containing protein. (289 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha. (265 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (469 aa)
G3VML6_SARHAIg-like domain-containing protein. (270 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (442 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
LOC105749196Ig-like domain-containing protein. (285 aa)
SKP2S-phase kinase associated protein 2. (420 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (234 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
G3VR65_SARHAIg-like domain-containing protein. (259 aa)
JAK3Tyrosine-protein kinase. (1110 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
LOC100919671Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
NCOR2Nuclear receptor corepressor 2. (2437 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
BLNKB cell linker. (462 aa)
TBK1TANK binding kinase 1. (732 aa)
LOC105749124Ig-like domain-containing protein. (351 aa)
G3VXF2_SARHACalreticulin. (419 aa)
POLKDNA polymerase kappa. (866 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1258 aa)
TAPBPTAP binding protein. (449 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (783 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (654 aa)
LOC100927399C-type lectin domain-containing protein. (329 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
TYK2Tyrosine-protein kinase. (1197 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LOC100933797Uncharacterized protein. (463 aa)
SAP30LSAP30 like. (117 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (348 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (275 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
G3W651_SARHAUncharacterized protein; Belongs to the peptidase C14A family. (282 aa)
CCND2CYCLIN domain-containing protein; Belongs to the cyclin family. (141 aa)
PIK3R2Uncharacterized protein. (738 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (520 aa)
HDAC1Hist_deacetyl domain-containing protein. (323 aa)
BCL2L11BCL2 like 11. (200 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (488 aa)
TNFAIP3TNF alpha induced protein 3. (792 aa)
SAHAI-12Ig-like domain-containing protein; Belongs to the MHC class I family. (364 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1255 aa)
IL6Uncharacterized protein. (212 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (199 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
LYNTyrosine-protein kinase. (514 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (933 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1075 aa)
SAP30Sin3A associated protein 30. (176 aa)
LOC100932670Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (495 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (473 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (355 aa)
CD19Ig-like domain-containing protein. (561 aa)
RUNX3RUNX family transcription factor 3. (314 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (509 aa)
CD3GCD3g molecule. (188 aa)
CD3DIg_4 domain-containing protein. (189 aa)
BTKTyrosine-protein kinase. (659 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
RB1RB transcriptional corepressor 1. (848 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (379 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (470 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (579 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (337 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (716 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
PDIA3Protein disulfide-isomerase. (506 aa)
G3WNV5_SARHAIg-like domain-containing protein. (124 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (536 aa)
VIMVimentin; Belongs to the intermediate filament family. (289 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
CALRCalreticulin. (418 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
CIR1Corepressor interacting with RBPJ, 1. (476 aa)
E2F3E2F transcription factor 3. (337 aa)
G3WUJ4_SARHA25A_SYNTH_3 domain-containing protein. (96 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (423 aa)
LOC10092826425A_SYNTH_3 domain-containing protein. (368 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (694 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (445 aa)
STAT1Signal transducer and activator of transcription. (762 aa)
DDB2Damage specific DNA binding protein 2. (406 aa)
CD58Uncharacterized protein. (246 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (727 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
LOC100914443Uncharacterized protein. (187 aa)
LOC10574957725A_SYNTH_3 domain-containing protein. (401 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
LOC100914703Uncharacterized protein. (192 aa)
LOC100914965Uncharacterized protein. (183 aa)
BCL2BCL2 apoptosis regulator. (227 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (414 aa)
CD247CD247 molecule. (166 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
Server load: low (28%) [HD]