STRINGSTRING
PXN PXN PIK3CB PIK3CB LOC111720510 LOC111720510 CASP8 CASP8 GTF2A1 GTF2A1 ATP6V0D2 ATP6V0D2 YWHAH YWHAH EIF2AK2 EIF2AK2 SYK SYK CCNA2 CCNA2 CCR4 CCR4 LOC100916825 LOC100916825 CDC20 CDC20 G3VGC5_SARHA G3VGC5_SARHA LOC105749194 LOC105749194 HDAC7 HDAC7 LOC100932860 LOC100932860 LOC100913958 LOC100913958 LOC100913692 LOC100913692 G3VJJ0_SARHA G3VJJ0_SARHA LOC100934072 LOC100934072 NFKBIA NFKBIA G3VK11_SARHA G3VK11_SARHA CCND1 CCND1 RBPJ RBPJ CDK6 CDK6 LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA G3VMC7_SARHA G3VMC7_SARHA LOC100929673 LOC100929673 STAT5B STAT5B CCNA1 CCNA1 G3VML6_SARHA G3VML6_SARHA LOC100928127 LOC100928127 LOC105749196 LOC105749196 SKP2 SKP2 CCND3 CCND3 HDAC11 HDAC11 LOC100929360 LOC100929360 JAK3 JAK3 BAK1 BAK1 YWHAQ YWHAQ GTF2B GTF2B CCR8 CCR8 G3VT75_SARHA G3VT75_SARHA TBPL1 TBPL1 VAC14 VAC14 KAT2A KAT2A RBL2 RBL2 ACTN4 ACTN4 LOC105749124 LOC105749124 EP300 EP300 MRPS18B MRPS18B RANBP1 RANBP1 NFKB1 NFKB1 TRAF2 TRAF2 DDX3X DDX3X MAPK1 MAPK1 CDK2 CDK2 PIK3R1 PIK3R1 KAT2B KAT2B UBR4 UBR4 CASP3 CASP3 TRAF3 TRAF3 TBPL2 TBPL2 PRKACA PRKACA CDK4 CDK4 G3W651_SARHA G3W651_SARHA CCND2 CCND2 PIK3R2 PIK3R2 GTF2E2 GTF2E2 DNAJA3 DNAJA3 CREB3L3 CREB3L3 UBE3A UBE3A ATF6B ATF6B HDAC1 HDAC1 MDM2 MDM2 PKM PKM IL6ST IL6ST SAHAI-12 SAHAI-12 CCR3 CCR3 MAPK3 MAPK3 ATF2 ATF2 HDAC3 HDAC3 YWHAB YWHAB LOC100913351 LOC100913351 LOC100913616 LOC100913616 CDKN1B CDKN1B CDKN1A CDKN1A CREB3L2 CREB3L2 DDB1 DDB1 LYN LYN CREB3L4 CREB3L4 GTF2A2 GTF2A2 USP7 USP7 ACTN1 ACTN1 CREB5 CREB5 HDAC2 HDAC2 YWHAZ YWHAZ SRF SRF RBPJL RBPJL CREBBP CREBBP CREB1 CREB1 RB1 RB1 ATF4 ATF4 TRAF5 TRAF5 CREB3 CREB3 JAK1 JAK1 REL REL LTBR LTBR YWHAE YWHAE MAD1L1 MAD1L1 STAT3 STAT3 GTF2A1L GTF2A1L HDAC5 HDAC5 HDAC8 HDAC8 LOC100913731 LOC100913731 CREB3L1 CREB3L1 SND1 SND1 TP53 TP53 TBP TBP GTF2H3 GTF2H3 GTF2H1 GTF2H1 GTF2E1 GTF2E1 CCNE1 CCNE1 RHOA RHOA PIK3CA PIK3CA PSMC1 PSMC1 CDK1 CDK1 CHEK1 CHEK1 SRC SRC CCNE2 CCNE2 POLB POLB GSN GSN MAPKAPK2 MAPKAPK2 VDAC3 VDAC3 GRB2 GRB2 EGR3 EGR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (295 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
LOC111720510STAT_bind domain-containing protein. (112 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
GTF2A1General transcription factor IIA subunit 1. (377 aa)
ATP6V0D2ATPase H+ transporting V0 subunit d2. (317 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (226 aa)
EIF2AK2Uncharacterized protein. (563 aa)
SYKTyrosine-protein kinase. (466 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (363 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LOC100916825Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CDC20Cell division cycle 20. (499 aa)
G3VGC5_SARHAIg-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
LOC105749194Ig-like domain-containing protein. (341 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1002 aa)
LOC100932860SKIP_SNW domain-containing protein. (536 aa)
LOC100913958Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100913692Histone H2B; Belongs to the histone H2B family. (126 aa)
G3VJJ0_SARHAIg-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
LOC100934072General transcription factor IIH subunit. (397 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
G3VK11_SARHAIg-like domain-containing protein. (244 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (465 aa)
CDK6Cyclin dependent kinase 6. (202 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
G3VMC7_SARHAIRF-3 domain-containing protein. (289 aa)
LOC100929673Histone H2B; Belongs to the histone H2B family. (126 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (469 aa)
G3VML6_SARHAIg-like domain-containing protein. (270 aa)
LOC100928127Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105749196Ig-like domain-containing protein. (285 aa)
SKP2S-phase kinase associated protein 2. (420 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (234 aa)
HDAC11Histone deacetylase 11. (325 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
JAK3Tyrosine-protein kinase. (1110 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (244 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (361 aa)
G3VT75_SARHAHistone H2B; Belongs to the histone H2B family. (134 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
VAC14Uncharacterized protein. (778 aa)
KAT2ALysine acetyltransferase 2A. (725 aa)
RBL2RB transcriptional corepressor like 2. (1065 aa)
ACTN4Actinin alpha 4. (855 aa)
LOC105749124Ig-like domain-containing protein. (351 aa)
EP300E1A binding protein p300. (1895 aa)
MRPS18BMitochondrial ribosomal protein S18B. (250 aa)
RANBP1RanBD1 domain-containing protein. (174 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
DDX3XUncharacterized protein; Belongs to the DEAD box helicase family. (675 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
KAT2BLysine acetyltransferase 2B. (710 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5136 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (275 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
TBPL2Uncharacterized protein. (183 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
G3W651_SARHAUncharacterized protein; Belongs to the peptidase C14A family. (282 aa)
CCND2CYCLIN domain-containing protein; Belongs to the cyclin family. (141 aa)
PIK3R2Uncharacterized protein. (738 aa)
GTF2E2General transcription factor IIE subunit 2. (216 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (425 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (465 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (878 aa)
ATF6BActivating transcription factor 6 beta. (709 aa)
HDAC1Hist_deacetyl domain-containing protein. (323 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (488 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (532 aa)
IL6STUncharacterized protein. (500 aa)
SAHAI-12Ig-like domain-containing protein; Belongs to the MHC class I family. (364 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (503 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
LOC100913351G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
LOC100913616G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (349 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (199 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
CREB3L2BZIP domain-containing protein. (517 aa)
DDB1Damage specific DNA binding protein 1. (1066 aa)
LYNTyrosine-protein kinase. (514 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (389 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1075 aa)
ACTN1Actinin alpha 1. (865 aa)
CREB5Uncharacterized protein. (109 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (473 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
SRFSerum response factor. (306 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (509 aa)
CREBBPCREB binding protein. (2452 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
RB1RB transcriptional corepressor 1. (848 aa)
ATF4Activating transcription factor 4. (344 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (579 aa)
CREB3BZIP domain-containing protein. (370 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
RELREL proto-oncogene, NF-kB subunit. (601 aa)
LTBRLymphotoxin beta receptor. (419 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
MAD1L1Uncharacterized protein. (471 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
GTF2A1LGeneral transcription factor IIA subunit 1 like. (557 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (979 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (379 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (526 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (888 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
TBPTATA-box binding protein. (308 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
GTF2H1Uncharacterized protein. (549 aa)
GTF2E1General transcription factor IIE subunit 1. (294 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (423 aa)
RHOAUncharacterized protein. (193 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (445 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
SRCTyrosine-protein kinase. (533 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
GSNGelsolin. (777 aa)
MAPKAPK2MAPK activated protein kinase 2. (307 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
GRB2Growth factor receptor bound protein 2. (191 aa)
EGR3Early growth response 3. (277 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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