STRINGSTRING
PXN PXN PIK3CB PIK3CB ITGA2 ITGA2 MSN MSN GPC3 GPC3 CAMK2D CAMK2D FZD2 FZD2 RPS6KB2 RPS6KB2 WNT10B WNT10B CCND1 CCND1 IGF2 IGF2 FAS FAS TWIST2 TWIST2 SOS2 SOS2 EIF4B EIF4B LOC100924383 LOC100924383 LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA TNF TNF FLNB FLNB NANOG NANOG PLAUR PLAUR FZD6 FZD6 ANK2 ANK2 FLNC FLNC VAV1 VAV1 FRS2 FRS2 LOC100929360 LOC100929360 WNT8B WNT8B COL1A2 COL1A2 LUM LUM RPS6 RPS6 PPP1CA PPP1CA MAPK13 MAPK13 THBS1 THBS1 MMP9 MMP9 ERBB3 ERBB3 PTPN11 PTPN11 DCN DCN ARAF ARAF PAK1 PAK1 ITPR3 ITPR3 TGFB1 TGFB1 TLR2 TLR2 TIAM1 TIAM1 MAPK1 MAPK1 PDPK1 PDPK1 WNT5A WNT5A CBL CBL PIK3R1 PIK3R1 IGF1 IGF1 SDC2 SDC2 G3W2P3_SARHA G3W2P3_SARHA CTNNB1 CTNNB1 KDR KDR PRKCB PRKCB IQGAP1 IQGAP1 LOC100933802 LOC100933802 PLAU PLAU SMO SMO AKT1 AKT1 ITGAV ITGAV PPP1CB PPP1CB MRAS MRAS CASP3 CASP3 PRKACA PRKACA MAP2K2 MAP2K2 FN1 FN1 G3W651_SARHA G3W651_SARHA CD63 CD63 EZR EZR FZD4 FZD4 WNT7B WNT7B PRKCA PRKCA PIK3R2 PIK3R2 WNT5B WNT5B WNT8A WNT8A MDM2 MDM2 WNT11 WNT11 FGF2 FGF2 VAV2 VAV2 WNT7A WNT7A HCLS1 HCLS1 MAPK3 MAPK3 PTK2 PTK2 RAF1 RAF1 ITGA5 ITGA5 TFAP4 TFAP4 CDKN1A CDKN1A PLCG2 PLCG2 PDCD4 PDCD4 HIF1A HIF1A MMP2 MMP2 WNT9A WNT9A ITPR1 ITPR1 ACTB ACTB VTN VTN SMAD2 SMAD2 FZD7 FZD7 FZD5 FZD5 HSPB2 HSPB2 PPP1CC PPP1CC COL1A1 COL1A1 PPP1R12B PPP1R12B IGF1R IGF1R WNT3A WNT3A ERBB4 ERBB4 VAV3 VAV3 IHH IHH WNT9B WNT9B ROCK1 ROCK1 PTCH1 PTCH1 HPSE2 HPSE2 WNT3 WNT3 SOS1 SOS1 STAT3 STAT3 GPC1 GPC1 WNT16 WNT16 WNT6 WNT6 CAMK2B CAMK2B ERBB2 ERBB2 CAV2 CAV2 PLCE1 PLCE1 DROSHA DROSHA LOC100913731 LOC100913731 ESR1 ESR1 CAV1 CAV1 TP53 TP53 HBEGF HBEGF HGF HGF MET MET HOXD10 HOXD10 RRAS2 RRAS2 RPS6KB1 RPS6KB1 WNT4 WNT4 RHOA RHOA PTPN6 PTPN6 ITGB1 ITGB1 PIK3CA PIK3CA ANK1 ANK1 FZD10 FZD10 HSPG2 HSPG2 TIMP3 TIMP3 WNT2B WNT2B WNT2 WNT2 TLR4 TLR4 CAMK2A CAMK2A FZD3 FZD3 SRC SRC TGFB2 TGFB2 FGFR1 FGFR1 ITGB3 ITGB3 ANK3 ANK3 ARHGEF12 ARHGEF12 GRB2 GRB2 FZD1 FZD1 FASLG FASLG IL12B IL12B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (295 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
ITGA2Integrin_alpha2 domain-containing protein. (326 aa)
MSNFERM domain-containing protein. (234 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (449 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
FZD2G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (235 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (473 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
IGF2Insulin like growth factor 2. (184 aa)
FASUncharacterized protein. (283 aa)
TWIST2Twist family bHLH transcription factor 2. (161 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1329 aa)
EIF4BEukaryotic translation initiation factor 4B. (608 aa)
LOC100924383FERM domain-containing protein. (378 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
FLNBFilamin B. (2507 aa)
NANOGHomeobox domain-containing protein. (282 aa)
PLAURUncharacterized protein. (246 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (718 aa)
ANK2Ankyrin 2. (3759 aa)
FLNCFilamin C. (2727 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
LOC100929360Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
COL1A2Collagen type I alpha 2 chain. (1332 aa)
LUMLumican. (341 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
THBS1Thrombospondin 1. (1180 aa)
MMP9Matrix metallopeptidase 9. (717 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1328 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (627 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2665 aa)
TGFB1TGF_BETA_2 domain-containing protein. (162 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (783 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1594 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PDPK1Protein kinase domain-containing protein. (558 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
CBLCbl proto-oncogene. (774 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
IGF1Insulin like growth factor 1. (130 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
G3W2P3_SARHAPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (150 aa)
CTNNB1Catenin beta 1. (781 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1629 aa)
LOC100933802Uncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
PLAUPlasminogen activator, urokinase. (431 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (759 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1013 aa)
PPP1CBSerine/threonine-protein phosphatase. (268 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (275 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
FN1Fibronectin 1. (2302 aa)
G3W651_SARHAUncharacterized protein; Belongs to the peptidase C14A family. (282 aa)
CD63Tetraspanin. (249 aa)
EZREzrin. (586 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
PIK3R2Uncharacterized protein. (738 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (448 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (488 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
VAV2Vav guanine nucleotide exchange factor 2. (699 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (293 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (558 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1061 aa)
TFAP4Transcription factor AP-4. (346 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
PDCD4Programmed cell death 4. (469 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
MMP2Matrix metallopeptidase 2. (665 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2696 aa)
ACTBActin beta. (375 aa)
VTNSMB domain-containing protein. (474 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (336 aa)
COL1A1Collagen type I alpha 1 chain. (1475 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (934 aa)
IGF1RTyrosine-protein kinase receptor. (1061 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (248 aa)
ERBB4Uncharacterized protein. (596 aa)
VAV3Vav guanine nucleotide exchange factor 3. (846 aa)
IHHIndian hedgehog signaling molecule. (310 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ROCK1Uncharacterized protein. (516 aa)
PTCH1Patched 1. (1433 aa)
HPSE2Uncharacterized protein. (149 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (536 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PLCE1Phosphoinositide phospholipase C. (1808 aa)
DROSHADrosha ribonuclease III. (1371 aa)
LOC100913731Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (588 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (188 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
HBEGFHeparin binding EGF like growth factor. (210 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (761 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1379 aa)
HOXD10Homeobox D10. (340 aa)
RRAS2RAS related 2. (175 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (527 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (264 aa)
RHOAUncharacterized protein. (193 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (799 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
ANK1Ankyrin 1. (1920 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
HSPG2SEA domain-containing protein. (159 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (171 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (828 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SRCTyrosine-protein kinase. (533 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
FGFR1Fibroblast growth factor receptor. (818 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ANK3Ankyrin 3. (3921 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1542 aa)
GRB2Growth factor receptor bound protein 2. (191 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (339 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (270 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
Server load: low (38%) [HD]