STRINGSTRING
PIK3CB PIK3CB CALM1-2 CALM1-2 EGF EGF SHC3 SHC3 CAMK2D CAMK2D CALML4 CALML4 CCND1 CCND1 CDK6 CDK6 SOS2 SOS2 PTEN PTEN LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA GADD45G GADD45G SHC1 SHC1 BAK1 BAK1 CALML3 CALML3 ARAF ARAF POLK POLK MAPK1 MAPK1 PIK3R1 PIK3R1 IGF1 IGF1 GADD45B GADD45B PRKCB PRKCB AKT1 AKT1 MAP2K2 MAP2K2 CDK4 CDK4 PRKCA PRKCA CAMK1G CAMK1G PIK3R2 PIK3R2 PDGFA PDGFA TGFA TGFA MDM2 MDM2 MAPK3 MAPK3 RAF1 RAF1 SHC2 SHC2 CDKN1A CDKN1A PLCG2 PLCG2 CAMK1D CAMK1D PDGFRA PDGFRA IGF1R IGF1R RB1 RB1 SOS1 SOS1 PDGFB PDGFB CAMK2B CAMK2B SHC4 SHC4 TP53 TP53 E2F3 E2F3 PIK3CA PIK3CA PDGFRB PDGFRB DDB2 DDB2 CAMK2A CAMK2A GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
EGFEpidermal growth factor. (1129 aa)
SHC3SHC adaptor protein 3. (422 aa)
CAMK2DCaMKII_AD domain-containing protein. (87 aa)
CALML4Calmodulin like 4. (155 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
CDK6Cyclin dependent kinase 6. (202 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1329 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SHC1SHC adaptor protein 1. (569 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (627 aa)
POLKDNA polymerase kappa. (866 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
IGF1Insulin like growth factor 1. (130 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
CAMK1GProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa)
PIK3R2Uncharacterized protein. (738 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
TGFATransforming growth factor alpha. (159 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (488 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
SHC2Uncharacterized protein. (479 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (298 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1101 aa)
IGF1RTyrosine-protein kinase receptor. (1061 aa)
RB1RB transcriptional corepressor 1. (848 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (641 aa)
SHC4SHC adaptor protein 4. (538 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
E2F3E2F transcription factor 3. (337 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1092 aa)
DDB2Damage specific DNA binding protein 2. (406 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (488 aa)
GRB2Growth factor receptor bound protein 2. (191 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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