STRINGSTRING
TYMP TYMP EGF EGF CCND1 CCND1 LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA THBS1 THBS1 MMP9 MMP9 ARAF ARAF UPK3A UPK3A DAPK1 DAPK1 MAPK1 MAPK1 MAP2K2 MAP2K2 CDK4 CDK4 MDM2 MDM2 MAPK3 MAPK3 RAF1 RAF1 CDH1 CDH1 CDKN1A CDKN1A MMP2 MMP2 RPS6KA5 RPS6KA5 RB1 RB1 MMP1 MMP1 ERBB2 ERBB2 TP53 TP53 E2F3 E2F3 HBEGF HBEGF CXCL8 CXCL8 G3WUW9_SARHA G3WUW9_SARHA SRC SRC DAPK2 DAPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (473 aa)
EGFEpidermal growth factor. (1129 aa)
CCND1Cyclin_C domain-containing protein. (141 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
THBS1Thrombospondin 1. (1180 aa)
MMP9Matrix metallopeptidase 9. (717 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (627 aa)
UPK3AUroplakin 3A. (287 aa)
DAPK1Uncharacterized protein. (737 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (488 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (835 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (165 aa)
MMP2Matrix metallopeptidase 2. (665 aa)
RPS6KA5Ribosomal protein S6 kinase. (808 aa)
RB1RB transcriptional corepressor 1. (848 aa)
MMP1Matrix metallopeptidase 1. (473 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
E2F3E2F transcription factor 3. (337 aa)
HBEGFHeparin binding EGF like growth factor. (210 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
G3WUW9_SARHAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (371 aa)
SRCTyrosine-protein kinase. (533 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (365 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.