(56 nodes) Chronic myeloid leukemia network (Sarcophilus harrisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
	LOC111720510	STAT_bind domain-containing protein. (112 aa)
	BCR	Uncharacterized protein. (623 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (194 aa)
	SHC3	SHC adaptor protein 3. (422 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (321 aa)
	CCND1	Cyclin_C domain-containing protein. (141 aa)
	CDK6	Cyclin dependent kinase 6. (202 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1329 aa)
	LOC100929426	Uncharacterized protein. (200 aa)
	G3VMA8_SARHA	Uncharacterized protein. (192 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	SHC1	SHC adaptor protein 1. (569 aa)
	BAK1	BCL2 antagonist/killer 1. (208 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (627 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (162 aa)
	POLK	DNA polymerase kappa. (866 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (980 aa)
	MAPK1	Mitogen-activated protein kinase. (348 aa)
	CBL	Cbl proto-oncogene. (774 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
	PIK3R2	Uncharacterized protein. (738 aa)
	HDAC1	Hist_deacetyl domain-containing protein. (323 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (488 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (439 aa)
	MAPK3	Mitogen-activated protein kinase. (375 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
	SHC2	Uncharacterized protein. (479 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (199 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (165 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (473 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (409 aa)
	BCL2L1	BCL2 like 1. (227 aa)
	RB1	RB transcriptional corepressor 1. (848 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (468 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1325 aa)
	SHC4	SHC adaptor protein 4. (538 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
	E2F3	E2F transcription factor 3. (337 aa)
	ABL1	Tyrosine-protein kinase. (1126 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (475 aa)
	DDB2	Damage specific DNA binding protein 2. (406 aa)
	MECOM	MDS1 and EVI1 complex locus. (1039 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	GAB2	GRB2 associated binding protein 2. (636 aa)
	GRB2	Growth factor receptor bound protein 2. (191 aa)

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCR	ENSSHAP00000019280	ENSSHAP00000001366	Tyrosine-protein kinase.	Uncharacterized protein.	0.930
ABL1	CBL	ENSSHAP00000019280	ENSSHAP00000009276	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.951
ABL1	CDKN1A	ENSSHAP00000019280	ENSSHAP00000013540	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.425
ABL1	CDKN1B	ENSSHAP00000019280	ENSSHAP00000013483	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1B.	0.425
ABL1	CRKL	ENSSHAP00000019280	ENSSHAP00000001508	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.972
ABL1	GRB2	ENSSHAP00000019280	ENSSHAP00000021710	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.963
ABL1	LOC111720510	ENSSHAP00000019280	ENSSHAP00000000119	Tyrosine-protein kinase.	STAT_bind domain-containing protein.	0.921
ABL1	RB1	ENSSHAP00000019280	ENSSHAP00000016483	Tyrosine-protein kinase.	RB transcriptional corepressor 1.	0.934
ABL1	RUNX1	ENSSHAP00000019280	ENSSHAP00000017397	Tyrosine-protein kinase.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.405
ABL1	SHC1	ENSSHAP00000019280	ENSSHAP00000005170	Tyrosine-protein kinase.	SHC adaptor protein 1.	0.927
ABL1	SHC2	ENSSHAP00000019280	ENSSHAP00000013356	Tyrosine-protein kinase.	Uncharacterized protein.	0.920
ABL1	SHC3	ENSSHAP00000019280	ENSSHAP00000002029	Tyrosine-protein kinase.	SHC adaptor protein 3.	0.927
ABL1	SHC4	ENSSHAP00000019280	ENSSHAP00000018142	Tyrosine-protein kinase.	SHC adaptor protein 4.	0.920
ABL1	STAT5B	ENSSHAP00000019280	ENSSHAP00000004406	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.921
ABL1	TP53	ENSSHAP00000019280	ENSSHAP00000018268	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.401
AKT1	BCL2L1	ENSSHAP00000010374	ENSSHAP00000016081	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 like 1.	0.924
AKT1	CDKN1A	ENSSHAP00000010374	ENSSHAP00000013540	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.965
AKT1	CDKN1B	ENSSHAP00000010374	ENSSHAP00000013483	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.964
AKT1	CHUK	ENSSHAP00000010374	ENSSHAP00000000039	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.972
AKT1	GRB2	ENSSHAP00000010374	ENSSHAP00000021710	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.415