STRINGSTRING
PIK3CB PIK3CB G6PD G6PD PFKM PFKM GLS2 GLS2 PTEN PTEN LOC100929426 LOC100929426 G3VMA8_SARHA G3VMA8_SARHA HK1 HK1 SLC7A5 SLC7A5 PFKL PFKL G3VST0_SARHA G3VST0_SARHA FGFR2 FGFR2 MAPK1 MAPK1 PIK3R1 PIK3R1 PDHB PDHB TIGAR TIGAR AKT1 AKT1 SIRT3 SIRT3 MAP2K2 MAP2K2 PIK3R2 PIK3R2 SIRT6 SIRT6 HK2 HK2 PKM PKM IDH1 IDH1 HK3 HK3 RET RET KIT KIT MAPK3 MAPK3 PFKP PFKP RAF1 RAF1 IDH2 IDH2 HIF1A HIF1A SLC2A2 SLC2A2 PDGFRA PDGFRA GCK GCK ERBB2 ERBB2 SLC2A1 SLC2A1 PDHA1 PDHA1 LDHB LDHB TP53 TP53 LDHA LDHA MET MET PIK3CA PIK3CA NTRK1 NTRK1 GLS GLS PDGFRB PDGFRB NTRK3 NTRK3 PDK1 PDK1 FGFR1 FGFR1 FLT3 FLT3 PGAM1 PGAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (562 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (785 aa)
GLS2Glutaminase 2. (605 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
LOC100929426Uncharacterized protein. (200 aa)
G3VMA8_SARHAUncharacterized protein. (192 aa)
HK1Hexokinase 1. (922 aa)
SLC7A5Solute carrier family 7 member 5. (332 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (788 aa)
G3VST0_SARHAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
MAPK1Mitogen-activated protein kinase. (348 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (271 aa)
TIGARUncharacterized protein. (210 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (327 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (377 aa)
PIK3R2Uncharacterized protein. (738 aa)
SIRT6Sirtuin 6. (368 aa)
HK2Hexokinase 2. (917 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (532 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
HK3Hexokinase 3. (803 aa)
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (894 aa)
KITUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (947 aa)
MAPK3Mitogen-activated protein kinase. (375 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (799 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (435 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (518 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1101 aa)
GCKPhosphotransferase. (468 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (395 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (302 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (363 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1379 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
NTRK1Tyrosine-protein kinase receptor. (792 aa)
GLSGlutaminase. (550 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1092 aa)
NTRK3Tyrosine-protein kinase receptor. (825 aa)
PDK1Protein-serine/threonine kinase. (371 aa)
FGFR1Fibroblast growth factor receptor. (818 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (800 aa)
PGAM1Uncharacterized protein. (239 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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