STRINGSTRING
CHUK CHUK PIK3CB PIK3CB CALM1-2 CALM1-2 TXN2 TXN2 HSP90B1 HSP90B1 MGST1 MGST1 MAP2K7 MAP2K7 MAPK10 MAPK10 DUSP1 DUSP1 BMP4 BMP4 IL1R2 IL1R2 CALML4 CALML4 GSTT2B GSTT2B TNF TNF LOC100927430 LOC100927430 CALML3 CALML3 MAPK9 MAPK9 GSTM4 GSTM4 MAPK13 MAPK13 BMPR1A BMPR1A IL1R1 IL1R1 CYBA CYBA GSTM3 GSTM3 MMP9 MMP9 KEAP1 KEAP1 NFKB1 NFKB1 PRKCZ PRKCZ HSP90AA1 HSP90AA1 PIK3R1 PIK3R1 PIAS4 PIAS4 IL1A IL1A SDC2 SDC2 G3W2P3_SARHA G3W2P3_SARHA LOC100933797 LOC100933797 CTNNB1 CTNNB1 KDR KDR LOC100933802 LOC100933802 PRKAA2 PRKAA2 VCAM1 VCAM1 TRPV4 TRPV4 IL1B IL1B AKT1 AKT1 ITGAV ITGAV NOS3 NOS3 PIK3R2 PIK3R2 BMPR2 BMPR2 PDGFA PDGFA ACVR2A ACVR2A SQSTM1 SQSTM1 MEF2C MEF2C SELE SELE BMPR1B BMPR1B PTK2 PTK2 MGST2 MGST2 SUMO1 SUMO1 MMP2 MMP2 THBD THBD ACTB ACTB MAP3K5 MAP3K5 ARHGEF2 ARHGEF2 KLF4 KLF4 NCF2 NCF2 MAPK7 MAPK7 G3WKU6_SARHA G3WKU6_SARHA PRKAA1 PRKAA1 MAP2K5 MAP2K5 RAC2 RAC2 GPC1 GPC1 PDGFB PDGFB IFNG IFNG LOC100926572 LOC100926572 EDN1 EDN1 CAV2 CAV2 NQO1 NQO1 CAV1 CAV1 G3WRN5_SARHA G3WRN5_SARHA TP53 TP53 ITGA2B ITGA2B RHOA RHOA MGST3 MGST3 GSTO1 GSTO1 PIK3CA PIK3CA G3WWQ6_SARHA G3WWQ6_SARHA MEF2A MEF2A HSP90AB1 HSP90AB1 ACVR1 ACVR1 SRC SRC MAPK8 MAPK8 PLAT PLAT MAP3K7 MAP3K7 FOS FOS BCL2 BCL2 ITGB3 ITGB3 IKBKB IKBKB NFE2L2 NFE2L2 HMOX1 HMOX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (738 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (802 aa)
CALM1-2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TXN2Thioredoxin domain-containing protein. (165 aa)
HSP90B1Heat shock protein 90 beta family member 1. (803 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (524 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
BMP4Bone morphogenetic protein 4. (410 aa)
IL1R2Uncharacterized protein. (424 aa)
CALML4Calmodulin like 4. (155 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (218 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
LOC100927430Uncharacterized protein. (216 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
MAPK9Mitogen-activated protein kinase. (429 aa)
GSTM4Glutathione S-transferase mu 4; Belongs to the GST superfamily. (222 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
IL1R1Interleukin 1 receptor type 1. (570 aa)
CYBACytochrome b-245 alpha chain. (209 aa)
GSTM3Glutathione S-transferase mu 3. (226 aa)
MMP9Matrix metallopeptidase 9. (717 aa)
KEAP1Kelch like ECH associated protein 1. (623 aa)
NFKB1Nuclear factor kappa B subunit 1. (980 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (453 aa)
HSP90AA1HATPase_c domain-containing protein. (731 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PIAS4Protein inhibitor of activated STAT 4. (494 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (261 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
G3W2P3_SARHAPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (150 aa)
LOC100933797Uncharacterized protein. (463 aa)
CTNNB1Catenin beta 1. (781 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
LOC100933802Uncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
VCAM1Uncharacterized protein. (745 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (743 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (273 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1013 aa)
NOS3Nitric oxide synthase 3. (1022 aa)
PIK3R2Uncharacterized protein. (738 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SQSTM1Sequestosome 1. (401 aa)
MEF2CMyocyte enhancer factor 2C. (467 aa)
SELESelectin E. (680 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (397 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
SUMO1Small ubiquitin-related modifier. (72 aa)
MMP2Matrix metallopeptidase 2. (665 aa)
THBDThrombomodulin. (570 aa)
ACTBActin beta. (375 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1385 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1186 aa)
KLF4Kruppel like factor 4. (507 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (783 aa)
G3WKU6_SARHAC-C motif chemokine. (143 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
RAC2Rac family small GTPase 2. (192 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (536 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (167 aa)
LOC100926572Uncharacterized protein; Belongs to the GST superfamily. (232 aa)
EDN1Endothelin 1. (214 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (188 aa)
G3WRN5_SARHAUncharacterized protein. (212 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (371 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1057 aa)
RHOAUncharacterized protein. (193 aa)
MGST3Microsomal glutathione S-transferase 3. (153 aa)
GSTO1Uncharacterized protein; Belongs to the GST superfamily. (248 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
G3WWQ6_SARHAUncharacterized protein; Belongs to the GST superfamily. (240 aa)
MEF2AMyocyte enhancer factor 2A. (498 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
SRCTyrosine-protein kinase. (533 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (565 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (450 aa)
BCL2BCL2 apoptosis regulator. (227 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (598 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (283 aa)
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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