STRINGSTRING
ABD29719.1 ABD29719.1 ABD29720.1 ABD29720.1 ABD29721.1 ABD29721.1 mgrA mgrA ABD29828.1 ABD29828.1 ABD29829.1 ABD29829.1 ABD29830.1 ABD29830.1 ABD29831.1 ABD29831.1 ABD29832.1 ABD29832.1 ABD29955.1 ABD29955.1 ABD29956.1 ABD29956.1 ABD29957.1 ABD29957.1 aroD aroD ABD29959.1 ABD29959.1 ABD30696.1 ABD30696.1 ABD31441.1 ABD31441.1 ABD31442.1 ABD31442.1 fni fni corA corA ABD31634.1 ABD31634.1 ABD31635.1 ABD31635.1 ABD31671.1 ABD31671.1 ABD31858.1 ABD31858.1 ABD31859.1 ABD31859.1 crtN crtN crtM crtM crtQ crtQ crtP crtP crtO crtO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABD29719.1Mevalonate kinase, putative. (306 aa)
ABD29720.1Diphosphomevalonate decarboxylase. (327 aa)
ABD29721.1Phosphomevalonate kinase. (358 aa)
mgrAConserved hypothetical protein; Regulatory protein involved in autolytic activity, multidrug resistance and virulence. Controls autolysis by inactivating LytM, LytN (autolysins) and SarV (autolysis activator) and activating ArlRS, LrgAB and LytSR (autolysis inhibitors). Acts as a dual regulator for resistance to multiple drugs by inactivating NorB and tet38 and activating NorA. Positively controls the expression of virulence accessory gene regulator (agr) to promote alpha-hemolysin (hla) transcription and down-regulates staphylococcal accessory regulator (sarS), leading to repression o [...] (147 aa)
ABD29828.1Conserved hypothetical protein. (308 aa)
ABD29829.1Conserved hypothetical protein. (302 aa)
ABD29830.1Conserved hypothetical protein. (95 aa)
ABD29831.1Conserved hypothetical protein. (517 aa)
ABD29832.1Deoxyribodipyrimidine photolyase, putative; Belongs to the DNA photolyase family. (457 aa)
ABD29955.1Conserved hypothetical protein. (205 aa)
ABD29956.1Conserved hypothetical protein. (164 aa)
ABD29957.1Conserved hypothetical protein; Belongs to the OsmC/Ohr family. (140 aa)
aroD3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (238 aa)
ABD29959.1Conserved hypothetical protein. (179 aa)
ABD30696.1Geranyltranstransferase, putative; Belongs to the FPP/GGPP synthase family. (293 aa)
ABD31441.1Hypothetical protein. (61 aa)
ABD31442.1Conserved hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (295 aa)
fniConserved hypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (349 aa)
corAConserved hypothetical protein; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (315 aa)
ABD31634.1Conserved hypothetical protein. (163 aa)
ABD31635.1Conserved hypothetical protein. (139 aa)
ABD31671.1Conserved hypothetical protein. (193 aa)
ABD31858.1hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (425 aa)
ABD31859.1HMG-CoA synthase, putative. (388 aa)
crtNSqualene synthase, putative; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes three successive dehydrogenation reactions that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'- diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product. (502 aa)
crtMSqualene desaturase, putative; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid 4,4'-diapophytoene (dehydrosqualene). (287 aa)
crtQConserved hypothetical protein; Catalyzes the glycosylation of 4,4'-diaponeurosporenoate, i.e. the esterification of glucose at the C1'' position with the carboxyl group of 4,4'-diaponeurosporenic acid, to form glycosyl-4,4'- diaponeurosporenoate. This is a step in the biosynthesis of staphyloxanthin, an orange pigment present in most staphylococci strains (By similarity). (375 aa)
crtPConserved hypothetical protein; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of the terminal methyl side group of 4,4'- diaponeurosporene to form 4,4'-diaponeurosporen-4-al. (497 aa)
crtOConserved hypothetical protein; Catalyzes the acylation of glycosyl-4,4'- diaponeurosporenoate, i.e. the esterification of glucose at the C6'' position with the carboxyl group of the C(15) fatty acid 12- methyltetradecanoic acid, to yield staphyloxanthin. This is the last step in the biosynthesis of this orange pigment, present in most staphylococci strains (By similarity). (162 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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