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| | walR | Two-component response regulator, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a transcription regulator by direct binding to promoter regions. Positively controls the cell wall-hydrolytic activity through regulation of atlA and lytM, as well as induces transcription of isaA, sceD, ssaA, and four ssaA- related genes. Binds directly to the lytM, ssaA and is [...] (233 aa) |
| | walK | Sensory box histidine kinase VicK, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target ge [...] (608 aa) |
| | ABD29211.1 | Conserved hypothetical protein. (427 aa) |
| | ABD29212.1 | Conserved hypothetical protein. (262 aa) |
| | ABD29213.1 | Conserved hypothetical protein. (266 aa) |
| | ABD29456.1 | Conserved hypothetical protein. (349 aa) |
| | ABD29457.1 | ABC transporter, ATP-binding protein, putative. (225 aa) |
| | ABD29796.1 | Conserved hypothetical protein. (168 aa) |
| | graX | Conserved hypothetical protein; Plays a role in resistance against cationic antimicrobial peptides (CAMPs). Facilitates the activation of GraS to transduce the signal to GraR. (307 aa) |
| | graR | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. (224 aa) |
| | graS | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37. (346 aa) |
| | ABD29800.1 | ABC transporter ATP-binding protein, putative. (253 aa) |
| | ABD29801.1 | ABC transporter permease, putative. (629 aa) |
| | saeS | Sensor histidine kinase SaeS, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb), coa, Dnase, spa and cell wall-associated proteins (emp, eap, fnbA). Acts probably downstr [...] (351 aa) |
| | saeR | Response regulator, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (Hla, Hlb), Coa, DNase, Spa and cell wall- associated proteins (Emp, Eap, FnbA). Acts probably downstream of the Agr system in the regulatory c [...] (228 aa) |
| | ABD29849.1 | Conserved hypothetical protein. (157 aa) |
| | ABD30092.1 | Hypothetical protein. (33 aa) |
| | ABD30093.1 | Conserved hypothetical protein. (654 aa) |
| | ABD30094.1 | Conserved hypothetical protein. (106 aa) |
| | ABD30095.1 | ABC transporter, ATP-binding protein, putative. (213 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | smc | SMC family, C-terminal domain family; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1188 aa) |
| | ABD30407.1 | Hypothetical protein. (108 aa) |
| | ABD30408.1 | Cardiolipin synthetase, putative; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (493 aa) |
| | ABD30409.1 | ABC transporter, ATP-binding protein, putative. (302 aa) |
| | ABD30410.1 | Conserved hypothetical protein. (243 aa) |
| | ABD30411.1 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. (363 aa) |
| | ABD30412.1 | Conserved hypothetical protein. (200 aa) |
| | arlS | Conserved hypothetical protein; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR. ArlS/ArlR affects expression of the multidrug resistance transporter norA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (se [...] (451 aa) |
| | arlR | DNA-binding response regulator, putative; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the [...] (219 aa) |
| | ABD30662.1 | Conserved hypothetical phage protein. (675 aa) |
| | ABD30663.1 | Conserved hypothetical protein. (289 aa) |
| | srrB | Staphylococcal respiratory response protein SrrB, putative; Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Plays also an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to SrrA. In turn, SrrA binds [...] (583 aa) |
| | srrA | DNA-binding response regulator, putative; Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Plays also an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate (By similarity). Functions as a transcription regulator by direct binding to promoter regions of target genes (By similarity). (241 aa) |
| | ABD30666.1 | Ribosomal large subunit pseudouridine synthase B, putative; Belongs to the pseudouridine synthase RsuA family. (245 aa) |
| | scpB | Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (180 aa) |
| | scpA | Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (243 aa) |
| | ABD30669.1 | Conserved hypothetical protein. (168 aa) |
| | ABD30867.1 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. (553 aa) |
| | ABD30868.1 | Two-component response regulator, putative. (234 aa) |
| | vraR | DNA-binding response regulator VraR, putative; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Upon cellular stress, the histidine kinase VraS transfers the phosphoryl group onto VraR. Upon phosphorylation, VraR dimerizes at the N-terminal domain. In turn, phosphorylation-induced dimerization expand and enhance the VraR binding to its own promoter leading to increased expression and subsequent modulation of as many as 40 genes, which ultimately constitute the S.aureus response to cell wall damage. In addition, [...] (209 aa) |
| | ABD31149.1 | Histidine kinase, putative. (347 aa) |
| | ABD31150.1 | Conserved hypothetical protein. (233 aa) |
| | ABD31151.1 | Conserved hypothetical protein. (128 aa) |
| | ABD31153.1 | Conserved hypothetical protein; Belongs to the UPF0421 family. (328 aa) |
| | ABD31330.1 | Conserved hypothetical protein; Belongs to the SprT family. (151 aa) |
| | ABD31331.1 | S1 RNA binding domain protein. (716 aa) |
| | ABD31332.1 | Sigma factor B, putative; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (256 aa) |
| | rsbW | Anti-sigma B factor, putative; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) (By similarity). (169 aa) |
| | rsbV | STAS domain, putative; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family. (108 aa) |
| | ABD31335.1 | sigmaB regulation protein RsbU, putative. (262 aa) |
| | ABD31336.1 | sigmaB regulation protein RsbU, putative. (96 aa) |
| | mazF | Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single- stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. Belongs to the PemK/MazF family. (120 aa) |
| | mazE | Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity; Belongs to the MazE/EndoAI family. (56 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (119 aa) |
| | ABD31341.1 | Conserved hypothetical protein. (163 aa) |
| | ABD31342.1 | Conserved hypothetical protein. (527 aa) |
| | ABD31343.1 | Conserved hypothetical protein. (159 aa) |
| | kdpC | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (186 aa) |
| | kdpB | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (657 aa) |
| | kdpA | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (558 aa) |
| | ABD31347.1 | Hypothetical protein. (36 aa) |
| | kdpD | Sensor protein KdpD, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide production. May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. (885 aa) |
| | kdpE | DNA-binding response regulator, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide synthesis. Upon phosphorylation by KpdD, functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. Represses the transcription of kdpFABC operon. (231 aa) |
| | hrtA | Conserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). (221 aa) |
| | hrtB | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). (351 aa) |
| | hssR | DNA-binding response regulator, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (224 aa) |
| | hssS | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (457 aa) |
| | ABD31653.1 | Conserved hypothetical protein. (147 aa) |
| | ABD31654.1 | Conserved hypothetical protein. (151 aa) |
| | ABD31944.1 | Permease, putative domain protein. (666 aa) |
| | ABD31945.1 | ABC transporter, ATP-binding protein, putative. (251 aa) |
| | ABD31946.1 | Sensor histidine kinase, putative. (295 aa) |
| | ABD31947.1 | DNA-binding response regulator, putative. (221 aa) |
| | ABD31948.1 | Conserved hypothetical protein. (66 aa) |
| | ABD32021.1 | ABC transporter, ATP-binding protein, putative. (252 aa) |
| | ABD32022.1 | Permease, putative. (626 aa) |
| | ABD32041.1 | Hypothetical protein. (77 aa) |
| | ABD32057.1 | Hypothetical protein. (72 aa) |
| | ABD32062.1 | Conserved hypothetical protein. (62 aa) |
| | ABD32065.1 | Hypothetical protein. (77 aa) |
